Names for CROM (ISBT 021) Blood Group Alleles

Names for CROM blood group alleles v2.0 110914Names for CROM (ISBT 021) Blood Group AllelesGeneral description: The Cromer blood group system consists of 16 antigens carried ona GPI-linked glycoprotein (DAF, CD55) that consists of 481 aminoacids. It has a leader sequence of 34 amino acids and a GPI motifof 28 amino acids, both of which are cleaved from the membranebound protein.Gene name: CROMNumber of exons: 11Initiation codon: Beginning of exon 2Stop codon: Beginning of exon 11GenBank #: NM_000574Entrez Gene ID: 1604Reference allele (shaded):Accession number: M31516Preferred: CROM*01Acceptable: CR*A, or Cr a if inferred by haemagglutinationReference allele CROM*01 encodes CROM1, CROM2, CROM5, CROM6, CROM7 (IFC),CROM9, CROM10, CROM11, CROM12, CROM 13, CROM14, CROM15, CROM16Phenotype Allele name NucleotidechangeCROM:1 or Cra+)CROM*01 or CR*AExonAmino acidchange^CROM:–1 or Cr(a–) CROM*–01 679G>C 6 Ala227ProCROM:3 or Tc(b+) CROM*01.03 155G>T 2 52LeuCROM:4 or Tc(c+) CROM*01.04 155G>C 2 52ProCROM:–5 or Dr(a–) CROM*01.–05 596C>T 5 Ser199LeuCROM:–6 or Es(a–) CROM*01.–06 239T>A 2 Ile80AsnCROM:8 orWES(a+)CROM:–10 orUMC–CROM:–11 orGUTI–CROM:–12 orSERF–CROM:–13 orZENA–CROM:–14 orCROV–CROM:–15 orCRAM–CROM*01.08 245T>G 2 82ArgCROM*01.–10 749C>T 6 Thr250MetCROM*01.–11 719G>A 6 Arg240HisCROM*01.–12 647C>T 5 Pro216LysCROM*01.–13 726T>G 6 His242GlnCROM*01.–14 466G>A 3 Glu156LysCROM*01.–15 740A>G 6 Gln247ArgPage 1 of 2

Names for CROM blood group alleles v2.0 110914CROM:–16 orCROZ–CROM*01.–16 389G>A 3 Arg130His [1]Null phenotypesCROM:–7 or Inab CROM*01N.01 261G>A 2 Trp87StopCROM:–7 or Inab CROM*01N.02 263C>A 2 Ser88StopCROM:–7 or Inab CROM*01N.03 508C>T 4 Arg170StopCROM:–7 or Inab CROM*01N.04 367insA 3 Thr123fs;Glu128Stop [1]^ change from historical counting of #1 as Asp of the mature (membrane-bound protein);thus, all amino acid numbers have increased by 34.[1] Karamatic Crew V, et al. Two unusual cases within the Cromer blood groupsystem: I)a novel high incidence antigen Croz and II)a novel molecular basis ofInab phenotype. Transfus Med 2010; 20(suppl.1):12.Page 2 of 2