Oxidative Phosphorylation - Ecu

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• NADH from Glycolysis must be transportedinto the mitochondrion to be oxidized by therespiratory electron transport chain.• Only the electrons from NADH aretransported, these are used to form eitherNADH or FADH 2.• This is accomplished by one of two shuttlemechanisms.
Glycerophosphate Shuttle(skeletal muscle, brain)NADH, H +3-PhosphoglycerolDehydrogenaseNAD +CytosolH 2C - OHC = OCH 2OPO 32-DHAPH 2C - OHHO - C - HCH 2OPO 32-3-PhosphoglycerolETCe -FADH 2FlavoproteinD’haseFADInnermitochondrialmembrane
Page 1: OxidativePhosphorylation
Page 5 and 6: • Oxidative Phosphorylation: NADH
Page 7 and 8: Meaning of the standard reduction p
Page 9 and 10: Electron Transport Through Complex
Page 11 and 12: Complex III (Cytochrome bc Complex)
Page 13 and 14: Complete Q Cycle:intermembranespace
Page 15 and 16: Complex V (ATP Synthase; F F ATPase
Page 18 and 19: Binding Change Mechanism (Boyer):
Page 20 and 21: Uncouplers:• Lipid-soluble weak a
Page 22 and 23: Control of Ox. Phos.:Control is tie
Page 24 and 25: How many protons are translocatedpe

Oxidative Phosphorylation - Ecu

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