shellfish free glucosamine topical cream with chondroitin and vitamin e

SHELLFISH FREEGLUCOSAMINE TOPICAL CREAMWITH CHONDROITIN AND VITAMIN EUPC CODE 0 646420 2723 8NATURAL HEALTH PRODUCTSDIRECTORATE (NHPD) CLAIMS:NHPD claims pending for Jamieson GlucosamineTopical Cream are:• Soothing care for healthy joints• Supports pain-free movement of hands, wrists, hips,ankles, knees, neck and back 1,2,3GENERAL INFORMATIONCartilage is a tough, gel-like material that covers the endsof bones where they meet to form a joint. Cartilage allowsbones to glide smoothly across each other duringmovement, and acts as a shock absorber for the joints.Over time, normal “wear and tear” in the body causescartilage to crack and break away from the joints. As thisprotective coating wears away, the bones start to grindagainst each other during movement. 1,2,3 This can result ina condition known as osteoarthritis (OA), which ischaracterized by pain, inflammation and stiffness in thejoints; in particular, the joints of the hips, spine, knees, feetand hands. 1,2,3 Primary OA is the normal degeneration dueto decades of wear and tear and stress being placed on thecollagen of the cartilage. Secondary OA is due topredisposing factors such as trauma and previousinflammatory disease. Natural health products that containglucosamine can help relieve the pain caused by OA, andindividuals with age-related degenerative joint diseases oracute joint injuries may also benefit fromsupplementation. 1,2,3Glucosamine is a biological chemical that is naturallypresent in bone cartilage, where it forms the majorcushioning ingredients of the synovial fluids of the jointsand surrounding tissues. 1,2,3 As its name indicates,glucosamine is composed of a sugar molecule (glucose)and an amine group. While most sugars come from dietarysources and are burned for energy, amino sugars aremainly formed in the body and used primarily inmanufacturing tissue components. As such, glucosaminehelps form the proteoglycans that fit within the spaces incartilage netting that is needed to restore joint structure.Normal wear and tear during bodily functions means thattissues are constantly broken down (metabolized) andreplaced or restructured. Glucosamine amino sugars arethus continuously in demand. With age, the body’s abilityto produce glucosamine may become impaired, resulting inconsiderable dysfunction and pain. Therefore, glucosaminemetabolism is an important factor to consider in thedevelopment of osteoarthritis. As a “building block” ofcartilage, glucosamine can help to slow the development ofmild to moderate OA by protecting and strengtheningcartilage, allowing it to retain its cushioning effects andlubricate the joints. It also plays a role in preventingfurther joint damage, helps to reduce inflammation andsupports pain-free movement of the joints. 1,2,3Who can benefit from Glucosamine?Individuals that:• Suffer from pain or stiffness in the knees, hands, feetor hips• Experience a limited range of motion in the joints• Have swollen or inflamed knees or fingers• Experience arthritic back and neck pain• Have recently injured or sprained a joint• Are involved in any high intensity activities or highimpact sports 4• Have a family history of any joint diseasesGlucosamine is thought to be even more effective forrelieving the pain and inflammation of arthritis than nonsteroidalanti-inflammatory drugs (NSAIDs). 5 In fact,while NSAIDs provide pain relief from OA, they do notaddress the fundamental problem of cartilage loss, and canalso have serious side effects, such as internal bleeding orliver failure, with long-term use. 5Chondroitin is another substance that is naturally presentin joint cartilage. Chondroitin acts like a liquid “magnet”to help attract fluid around the cartilage. This fluid acts asa spongy shock absorber in the joints and also helps tosweep nutrients into the cartilage. In fact, without thisfluid, cartilage becomes malnourished, dry, thin andfragile. Chondroitin sulfate also inhibits various enzymesthat contribute to the breakdown of cartilage in the body.It is therefore effective for increasing joint mobility andslowing cartilage loss. Chondroitin sulfate worksFor Accidental Overdose (such as child ingesting formula)Dial 911, 0 for operator assistance or call your nearest Poison Control Centre.For Professional Use OnlyThe information contained here has been accumulated from many sources.Indications are not intended as cures, they are simply a guideline to be used at your professional discretion.For more information please visit www.jamiesonvitamins.com or call 1-800-265-5088 to speak to a Consumer Affairs representative.07/18/10

synergistically with glucosamine against osteoarthritispain. 6 Chondroitin has been found especially effective forosteoarthritis of the knee 7,8,9 and as effective as taking painmedication. 10,11Glucosamine and chondroitin sulfate have consistentlydemonstrated their ability in relieving pain associated withstiffness and osteoarthritis (OA). A study published in theJournal of Rheumatology was designed to determine theefficacy of topical glucosamine and chondroitin in thetreatment of OA of the knee. Results of this study suggestthat the use of glucosamine chondroitin cream is effectivein relieving the pain associated with OA of the knee withinfour weeks time. 12Vitamin E, in the form of tocopheryl acetate, is pure andnatural. This antioxidant, when topically applied,penetrates the layers of skin to reduce formation of freeradicals, which interfere with healing. 13,14 It is also knownto influence the production of collagen to improve skinstrength and elasticity. 14Jamieson Glucosamine Topical Cream is made withRegenasure brand Glucosamine which is a GlucosamineSulfate Potassium Chloride complex that is non-shellfishand non-animal derived. Most glucosamine products onthe market are made from chitin, a substance found inshellfish such as lobsters and crab. This can be a concernfor individuals with shellfish allergies. This glucosamine isderived from Aspergillus Niger fermented corn grown inNorth America. As a result, it is suitable for individualswith shellfish allergies.Jamieson Glucosamine Topical Cream is a naturalapproach to support pain-free movement of joints.Glucosamine in the topical form is highly bioavailable.This cream may help relieve osteoarthritic pain in thejoints of the hands, wrists, hips, ankles, knees, neck andback. Furthermore, the cream is effective because itdirectly targets the joints to provide immediate pain relief.It is ideal for individuals with osteoarthritis that have nothad success with oral glucosamine and chondroitin, or forthose who prefer to apply a topical formula.reveal both immediate and long-term effects of thebotanical complex on heavy painful legs, as well as aquestionnaire to measure the intensity of the effect felt.The four-week use of the botanical complex showed apositive trend of the users to score higher in the areas ofimprovement in heavy legs, feeling of coolness, toleranceand smell. 15What makes Glucosamine Topical Cream from JamiesonLaboratories different…and why does that difference meanbetter?1) Contains not only glucosamine as an active, but also abotanical complex.2) Glucosamine in a cream form is great for those whoprefer not to chew tablets or swallow capsules, or inaddition to these supplements.3) Our premium formulations are manufactured using the360 Pure process - a minimum of 360 quality teststhat guarantee traceability and reliability of rawmaterial, product safety, full potency and absoluteclinical purity.INGREDIENT INFORMATIONAqua, Glucosamine Sulfate, Stearic Acid, Steareth-2,Propylene Glycol, Steareth-21, Cetyl Alcohol,Cyclopentasiloxane, Cyclotetrasiloxane, Dimethiconol,Sodium Chondroitin Sulfate, Diazolidinyl Urea,Iodopropynyl Butylcarbamate, Polyacrylamide, C13-14Isoparaffin, Laureth-7, Tocopheryl Acetate, MenthaArvensis Leaf Oil, Medica Limonum (Lemon) Peel Oil,Cupressus Sempervirens Leaf/Nut/Stem Oil, LavandulaHybrida Oil, Cistus Ladaniferus Oil, Salix Alba (Willow)Bark Extract, Sodium Hydroxide.DIRECTIONSAdults – Apply on affected area as needed, massageslowly and let penetrate. Store between 15 ºC-25 ºC, awayfrom children.Glucosamine Topical Cream also contains 100% pure andnatural essential oils, which bring relief and refreshment toheavy and painful legs. This botanical complex includesessential oils renowned for their physical andpsychological benefits. An in vivo study was conducted toFor Accidental Overdose (such as child ingesting formula)Dial 911, 0 for operator assistance or call your nearest Poison Control Centre.For Professional Use OnlyThe information contained here has been accumulated from many sources.Indications are not intended as cures, they are simply a guideline to be used at your professional discretion.For more information please visit www.jamiesonvitamins.com or call 1-800-265-5088 to speak to a Consumer Affairs representative.07/18/10

INDICATED BENEFITS• Supports pain-free movement of hands, wrists, hips,ankles, knees, neck and back. 1,2,3• Absorbs quickly for fast acting reliefNUTRIENT INTERACTIONSDrug InteractionsNone known when taken as directed.Nutrient DepletionsNone known when taken as directed.Supportive InteractionsOral glucosamine and chondroitin, niacinaminde, SAMe.WARNINGS AND PRECAUTIONSFor external use only. Avoid contact with eyes. In case ofaccidental ingestion, seek medical attention immediately.Consult a health care practitioner if you are pregnant orbreastfeeding.TOXICITY, ADVERSE REACTIONS, ANDSIDE EFFECTSNone known when taken as directed.REFERENCES1. Braham, R., Dawson, B., Goodman, C. (2003). The effect ofglucosamine supplementation on people experiencing regularknee pain. British Journal of Sports Medicine, 37:45-49.2. Towheed, T.E. & Anastassiades, T. (2007). Glucosaminetherapy for osteoarthritis: An update. The Journal ofRheumatology, 34(9):1787-1790.3. Houpt, J.B., McMillan, R., Wein, C., Paget-Dellio, S.D.(1999). Effect of glucosamine hydrochloride in the treatmentof pain of osteoarthritis of the knee. Journal ofRheumatology, 26(11):2423-2430.4. Ostojic, S.M., Arsic, M., Prodanovic, S., Vukovic, J.,Zlatanovic, M. (2007). Glucosamine administration inathletes: effects on recovery of acute knee injury. Res SportsMed, 15(2):113-24.6. Huskisson, E.C. (2008). Glucosamine and chondroitin forosteoarthritis. J Int Med Res. Nov-Dec;36(6):1161-79.7. Uebelhart, D., Thonar, E.J., Delmas, P.D., Chant Raine, A.,Vignon, E. (1998). Effects of oral chondroitin sulfate on theprogression of knee osteoarthritis: a pilot study.Osteoarthritis Cartilage 6(Suppl A):39-46.8. Mazières, B., Combe, B., Phan Van, A., Tondut, J.,Grynfeltt, M. (2001). Chondroitin sulphate in osteoarthritisof the knee; a prospective, double-blind, placebo-controlledmulticenter clinical study. Journal of Rheumatology,28:173-181.9. Mazières, B., Hucher, M., Zaïm, M., Garnero P. (2007).Effect of chondroitin sulphate in symptomatic kneeosteoarthritis: a multicentre, randomized, double-blind,placebo-controlled study. Annals of the RheumaticDiseases, 66(5):639-645.10. Bourgeois, P., Chales, G., Dehais, J., Delcambre, B., Kuntz,J.L., Rosenberg, S. (1998). Efficacy and tolerability ofchondroitin sulfate 1200 mg/day vs chondroitin sulfate 3 x400 mg/day vs placebo. Osteoarthritis Cartilage 6(SupplA):25-30.11. Bucsi, L., Poor, G. (1998). Efficacy and tolerability of oralchondroitin sulfate as a symptomatic slow acting drug forosteoarthritis (SYSADOA) in the treatment of kneeosteoarthritis. Osteoarthritis Cartilage 6(Suppl A):31-36.12. Cohen, M., Wolfe, R., Mai, T., Lewis, D.A. (2003).Randomized, double blind, placebo controlled trial of atopical cream containing glucosamine sulfate, chondroitinsulfate, and camphor for osteoarthritis of the knee. TheJournal of Rheumatology, 30 (3): 523-528.13. Wolf, R., Wolf, D., Ruocco, V. (1998). Vitamin E: theradical protector. J Eur Acad Dermatol Venereol,10(2):103-17.14. Nachbar, F. & Korting, H.C. (1995). The role of vitamin Ein normal and damaged skin. J Mol Med, 73(1):7-17.15. Gattefosse R.M. V-Tonic: The ally of light-feelinglegs.5. Ruane, R. & Griffiths, P. (2002). Glucosamine therapycompared to ibuprofen for joint pain. Br J Community Nutr,Mar, 7(3):148-52.For Accidental Overdose (such as child ingesting formula)Dial 911, 0 for operator assistance or call your nearest Poison Control Centre.For Professional Use OnlyThe information contained here has been accumulated from many sources.Indications are not intended as cures, they are simply a guideline to be used at your professional discretion.For more information please visit www.jamiesonvitamins.com or call 1-800-265-5088 to speak to a Consumer Affairs representative.07/18/10