Vita-Vim for Women 50+ monograph.pdf - Jamieson Vitamins

VITA-VIM TM FOR WOMEN 50+UPC CODE 0 646420 6312 0NPN # 80024840NATURAL HEALTH PRODUCTSDIRECTORATE (NHPD) CLAIMS:Jamieson Vita-Vim for Women 50+ is pendingapproval for the following NHPD claim:- Helps the body to metabolize carbohydrates, fats,and proteins.- Helps to form red blood cells.- Helps normal growth and development.- Helps in tissue formation.- Helps in the development and maintenance of bones,cartilage, teeth, and gums.- A multi-vitamin/mineral supplement for themaintenance of good health.- Source of antioxidants for the maintenance of goodhealth.GENERAL INFORMATIONVita-Vim For Women 50+ is a new multivitamincustomized for women over the age of 50. It reflects thelatest scientific evidence on various nutrients and theirimportance to women’s health. In addition to a fullspectrum of vitamins and minerals, this multivitamincontains Boron, Vitamin K and increased Calcium toreduce the risk of osteoporosis, which is a concern forwomen as they age. It also contains higher levels of Lutein(for eye health), Cranberry (to help prevent urinary tractinfections) and B vitamins (for energy). Its precisioncombination of vitamins, minerals and other nutrientssupplies women with all of the essentials that may bemissing from their diet. Vita-Vim for Women 50+ alsopromotes the body’s immune defense systems and supportbone, breast and urinary tract health. Some of the keyingredients in this unique formula include:BoronThe World Health Organization (WHO) classifies boron asa probable essential trace element although the exactmechanism by which this nutrient exerts its biologicalactivity is unclear. WHO suggests an intake of 1.0 mg ofboron per day for adults to maintain optimal health. 6Vitamins and minerals are essential micronutrients thatenable a person to lead a vital, active and healthy life.These nutrients must be obtained through the diet sincethey are either not synthesized in a person’s body or aresynthesized at inadequate levels. However, many peoplereceive sub-optimal amounts of nutrients for a variety ofreasons. A daily multivitamin-mineral supplement cansupply missing nutrients in the diet and may also help toreduce the risk of developing certain health conditions. 1In fact, in 2002, the Journal of the American MedicalAssociation made a recommendation that all adults take adaily multivitamin in addition to eating a healthy diet. 2There are a number of factors influencing a person’snutritional status, which may make a multivitamin a wisechoice for the maintenance of overall good health. Suchfactors include an unbalanced diet with too little freshfruit, vegetables and whole grains 1 ; excessiveconsumption of processed or refined (nutrient-poor)foods 3 , which are readily available for consumption; acompromised digestive system 1 ; ingestion of excessivesalt, sugar, caffeine, or alcohol; use of prescriptionmedications that alter nutrient absorption oreffectiveness 4 ; and exposure to environmental stressorssuch as pollution 5 . In addition, individuals who regularlyskip meals, eat on the run, are under stress, or who followrestrictive diets may be missing important nutrients.For Accidental Overdose (such as child ingesting formula)Dial 911, 0 for operator assistance or call your nearest Poison Control Centre.Boron is an inorganic component of food that is widelyfound in nature. It mostly exists as 1 or more inorganic,oxygen containing borates. 7 High amounts (1.5 – 3.0mg/100 g) of boron are found in fruit, leafy vegetables,nuts, legumes, wine and cider. 6 Depending on its origin,drinking water can contain boron (0.5 mg/L) and bottledwater can have between 0.005 to 4.3 mg/L of boron. 6 Thebody may store boron for more than 21 days, allowing forfluctuations in intake of this nutrient. 6Boron has a positive impact on bone health. It improvescalcium homeostasis by limiting the loss of calciumthrough urine, reducing serum calcitonin and increasingserum 25-hydroxycholecalciferol. 6 Also, an adequateintake of boron increases the synthesis of corticosteroids,which in turn may inhibit inflammation in rheumatoidarthritis sufferers. 6Boron also plays a role in brain function by improvingmanual dexterity, eye-hand coordination, attention,perception and memory. 6High intakes of boron (10 mg/day) may lower bloodplatelet count and the risk of thrombosis. 6 This effect helpslower the risk of coronary heart disease, which is a concernfor many postmenopausal women. 6For Professional Use OnlyThe information contained here has been accumulated from many sources.Indications are not intended as cures, they are simply a guideline to be used at your professional discretion.For more information please visit www.jamiesonvitamins.com or call 1-800-265-5088 to speak to a Consumer Affairs representative.10/25/11

Finally, boron impacts the hormonal balance ofpostmenopausal women by raising plasma 17-[beta]estradiol. 6Vitamin KVitamin K is a fat soluble vitamin that is well known forthe role it plays in the coagulation of blood. However,vitamin K is also an important nutrient for supportingbone health, because it assists with calcium regulationand may help to slow the loss of bone that occurs withincreasing age. 8Vitamin K works with gamma-carboxyglutamic acid(Gla), an amino acid that forms part of several proteinsthat control calcium levels through a process known ascarboxylation. 9 One of the Gla proteins that requiresvitamin K to function properly is known as osteocalcin. 9By activating osteocalcin through a process calledcarboxylation, vitamin K helps this protein to “latch on”to calcium, where it then transports this mineral into thebones and holds it there in place. 8Conversely, in the absence of adequate vitamin K,osteocalcin remains uncarboxylated, and in this inactiveform, it is unable to regulate calcium. 9 As a result, themineral drifts out of the bones, leaving them porous andsusceptible to fracture. 9 The increased excretion ofcalcium can also promote calcification (hardening) of thetissues, as it settles into the arteries and other soft tissuesin the body. 8Obtaining an adequate amount of vitamin K is thereforean important factor in maintaining the strength of bones.In fact, scientific evidence shows that low dietary intakesof vitamin K are associated with a lower bone mineraldensity and a higher risk of hip fracture in women. 8LuteinLutein is a water-soluble antioxidant nutrient of thecarotenoid family. Significant amounts of lutein arefound in spinach, kale, turnips, collard greens, egg yolksand green peas. 10 The recommended intake is between 6and 20 mg per day, and it may be most effective whentaken with other antioxidants (i.e. vitamin C) andminerals (i.e. copper). 11,12 Excess amounts of this nutrientnot utilized by the body are excreted. 11When taken orally, lutein is absorbed via fat-solublemeans by the intestines, then transported to the bloodstream to finally reach the macula of the eye. Thisnutrient might prevent and treat age-related maculardegeneration (ARMD) 10,11 – the leading cause of visualFor Accidental Overdose (such as child ingesting formula)Dial 911, 0 for operator assistance or call your nearest Poison Control Centre.disability in the developed world. Lutein may also have aprotective effect on cataract formation. 11 Lutein increasesthe measurement of macular pigment optical density(MPOD), although it is unknown at which stage of thedisease it is most effective. 11 Also, this nutrient mayabsorb short wavelength blue light that enters the eye,consequently lowering light-associated damage to themascula and crystalline lens. 11CalciumCalcium is an essential mineral that plays an important rolein building stronger, denser bones. This mineral is alsoinvolved in neurotransmitter release and musclecontraction. 1399 percent of the body’s calcium is stored in the bones andteeth. 14 Bone mass peaks between the ages of 18-25, afterwhich time bone loss occurs. 13Sources of calcium include milk, cheese, seaweeds, nuts,seeds, blackstrap molasses, beans, broccoli and collardgreens and fortified soy milk. Recommended calciumintake for adults ranges from 1000 to 1200 mg per day. 14Calcium has low toxicity and vitamin D is required toabsorb this mineral. Long-term poor intake of calcium canlead to rickets, poor blood clotting and osteoporosis inmenopausal women. 13Menopause accelerates bone loss because of decreasedestrogen levels, and fractures become common. 13 Alongwith exercise and a healthy diet, calcium supplementationcan reduce the risk of significant bone loss. 13Vitamin DVitamin D, often referred to as the “sunshine vitamin”, is afat-soluble vitamin, but is unique in that it is alsoconsidered to be a hormone. 15 Vitamin D3 is well-knownfor the important roles it plays in helping the body toabsorb calcium as well as maintaining strong bones toprevent osteoporosis. 16 However, new studies also showthat vitamin D may be effective for helping to reduce therisk of certain cancers by up to 60%:• Researchers from the Moores Cancer Center at UCSDcollected and analyzed data from 63 observationalstudies that looked at the relationship between vitaminD status and the risk of developing cancer. 16 Theauthors concluded that adequate vitamin Dsupplementation may offer a protective effect againstthe risk of breast, ovarian, colon and other cancers. 16For Professional Use OnlyThe information contained here has been accumulated from many sources.Indications are not intended as cures, they are simply a guideline to be used at your professional discretion.For more information please visit www.jamiesonvitamins.com or call 1-800-265-5088 to speak to a Consumer Affairs representative.10/25/11

• In a four-year study, almost 1200 healthy postmenopausalwomen were randomly assigned toreceive calcium alone (1400-1500 mg daily),calcium plus vitamin D3 (1100 IU daily) or aplacebo. 17 Researchers found that those women whotook calcium plus vitamin D3 had a substantialreduction in all-cancer incidence compared withthose who did not take the supplements. 17Canadians generally do not receive enough sunlight tomeet their vitamin D needs, particularly during the darkwinter months. 14 In addition, very few foods naturallycontain vitamin D – our primary source is fortified milk,as well as fatty fish such as salmon, and cereals that arefortified with this important nutrient. The daily dose ofVita-Vim For Women 50+ contains 1,000 IU of vitaminD3 (the same form naturally produced in the body duringsun exposure) to reflect the current vitamin Drecommendations for healthy adults from the Institute ofMedicine. 18 While many researchers now adviseincreasing daily vitamin D intake to 1,000 IU, thisamount is still well below the safe upper intake level of4,000 IU per day established by the National Academy ofSciences. 18CranberryThe urinary tract is comprised of the kidneys, ureters,bladder and urethra, 19 which work together to help thebody rid itself of waste products in the form of urine.Normally, urine stored in the bladder is sterile; only asmall amount of bacteria resides in the urethra, whichgets washed away as urine passes out of the body.However, if other types of bacteria gain entry into theurethra, and travel up through the urinary tract, a urinarytract infection (UTI) can result. 19 The most common typeof UTI is cystitis, or an infection of the bladder. 19 It istypically caused by an overgrowth of Escherichia coli (E.coli) bacteria, and includes uncomfortable symptomssuch as pain, itching and a burning sensation duringurination. 19 UTIs occur much more frequently in womenthan in men. 20Once E. coli bacteria enter the urinary tract, they are ableto multiply and cause an infection. E. coli are coveredwith tiny, fingerlike projections on their cell walls. 20 Atthe tips of these projections are glycoproteins (complexesformed by amino acids and sugars) known as lectins. 20The E. coli lectins attach themselves to the walls of thebladder and urinary tract, and therefore, cannot bewashed out of the body with the normal flow of urine. 20Cranberries (Vaccinum macrocarpon) are native to NorthAmerica and were consumed as food by the local nativeAmericans for centuries before the arrival of thePilgrims. 21 Drinking cranberry juice then became atraditional method used by the newcomers to preventurinary tract infections (UTIs). 21 However, drinkingcranberry juice to treat a UTI typically includes theingestion of unwanted calories, artificial preservatives,colours, flavours, sodium and refined sugar. Vita-Vim forWomen 50+ contains cranberry to help reduce the risk ofbladder infections in women. This ingredient contains allof the health benefits of cranberries without thedisadvantages associated with juice.Upon consumption, cranberries produce a substanceknown as hippuric acid, which increases the acidity of theurine. This helps prevent the growth of infection-causingE. coli bacteria, which cannot survive in an acidicenvironment. 20 In addition, cranberries contain naturallyoccurring compounds called proanthocyanins, whichpossess antibacterial activity. These proanthocyanins workby inhibiting bacterial adhesion to the cells lining thebladder and urinary tract. 20Lowered levels of IronIron is an essential nutrient that plays a central role inoxygen transport and cellular energy metabolism. 16Approximately 70% of the iron in the body forms part ofhemoglobin, a protein found in red blood cells thattransports oxygen. 22 The remainder of iron is found inmyoglobin, a protein that supplies oxygen to the muscles,and also forms part of various enzymes and immunesystem compounds. 22 Low iron stores can lead to fatigue,weakness, decreased energy, loss of appetite and impairedcognitive functioning. 22 However, overconsumption ofiron can lead to toxicity, since this mineral can accumulatein the body’s organs. 22After menopause, a woman’s need for iron decreases.Unlike women of child-bearing age, post-menopausalwomen do not lose very much iron from the body andtherefore, have a lower risk of iron deficiency. 22 Vita-Vim for Women 50+ is specially formulated withlowered levels of iron to address the iron requirements ofthis population.Increased levels of Vitamin B 12 :Vitamin B 12 is an essential nutrient and a member of the Bcomplex family. Vitamin B 12 is water-soluble; however, itis the only B vitamin that can be stored by the body,mainly in the liver. 23 Although the human body storesFor Accidental Overdose (such as child ingesting formula)Dial 911, 0 for operator assistance or call your nearest Poison Control Centre.For Professional Use OnlyThe information contained here has been accumulated from many sources.Indications are not intended as cures, they are simply a guideline to be used at your professional discretion.For more information please visit www.jamiesonvitamins.com or call 1-800-265-5088 to speak to a Consumer Affairs representative.10/25/11

several years worth of vitamin B 12 vegetarians, or thosewho eat little to no animal protein, can be deficient sincethis vitamin is found predominantly in foods of animalorigin. 23 Stomach acid is required to separate vitamin B 12from the protein its bound to in food, where it is thencombined with a protein made by the body calledintrinsic factor, which helps transport the vitamin fromthe intestines into the blood. 24 As a person ages, theacidity in the stomach decreases, causing inadequateabsorption of vitamin B 12 from food sources. 24 Thus, theNational Institutes of Medicine recommends that anyoneover the age of 50 take a dietary supplement with vitaminB 12 . 24Vitamin B 12 acts as a coenzyme for normal DNAsynthesis, promotes growth, cell development, and bloodcell development. 23 It is also required for properdigestion, and the synthesis of proteins. Vitamin B 12 isrequires for the metabolism of carbohydrates, fats andproteins. 23 Vitamin B 12 is especially important for thesynthesis of DNA in tissues. Vitamin B 12 ensures thecontinuous DNA production and prevents the occurrenceof abnormal cells called megaloblasts. 23 This can lead topernicious anemia, wherein the body cannot makeenough red blood cells either due to a lack of vitaminB 12 , or an inability to absorb vitamin B 12 from the diet. 23Low levels of vitamin B 12 can cause pernicious anemia,numbness, tingling in the extremities, weakness and lossof balance. 23 A deficiency can result in vitamin B 12neuropathy, involving degeneration of nerve fibres andirreversible neurological damage. 23Vita-Vim For Women 50+ is formulated from naturalsources and is pharmaceutically tested to guarantee fullpotency and absolute clinical purity.What makes Vita-Vim For Women 50+ from JamiesonLaboratories different…and why does that differencemean better?1) Formulated with vitamin D3 (cholecalciferol), thesame form that is naturally produced in the body whenskin is exposed to sunlight. It is more easily absorbedand used by the body than the vitamin D2(ergocalciferol) form.2) Provides calcium and vitamin D to help build andmaintain strong bones.3) Formulated with less iron to reflect lowered ironrequirements for post-menopausal women.For Accidental Overdose (such as child ingesting formula)Dial 911, 0 for operator assistance or call your nearest Poison Control Centre.4) Contains no artificial colours, flavours or preservatives.5) Our premium formulations are manufactured using the360 Pure process - a minimum of 360 quality tests thatguarantee traceability and reliability of raw material,product safety, full potency and absolute clinical purity.INGREDIENT INFORMATIONAvailable as 90 capsules.Each capsule contains:VitaminsBeta-Carotene……………...…………………….…75 mcgVitamin A (Acetate)……...….…...112.5 mcg RAE/375 IUVitamin B 1 (Thiamine mononitrate)………………1.25 mgVitamin B 2 (Riboflavin)………………..…….........1.75 mgVitamin B 3 (Niacinaminde)……………...……..........10 mgPantothenic Acid (Calcium d-pantothenate)…...…...7.5 mgVitamin B 6 (Pyridoxine HCl).………………….….....4 mgVitamin B 12 (Cyanocobalamin).……………….....12.5 mcgVitamin C (Ascorbic acid)……….…….……………45 mgVitamin D3 (Cholecalciferol)……............12.5 mcg/500 IUVitamin E (d-alpha tocopheryl acetate)..13.4 mg AT/20 IUVitamin K 1 (Phytonadione)……………………...…25 mcgBiotin………………………………………….…....20 mcgFolate (Folic acid) ..................................................300 mcgMinerals:Iodine (Potassium iodide) ......................................125 mcgCalcium.................................................................... 200 mg(Calcium phosphate dibasic and Carbonate)Iron (Ferrous Fumarate)……………………..…..........2 mgMagnesium (Oxide)…………………………..….31.25 mgZinc (Oxide) ..............................................................7.5 mgCopper (Sulfate) ...........................................................1 mgChromium (HVP* Chelate) .....................................75 mcgSelenium (HVP* Chelate) .....................................27.5 mcgManganese (Sulfate) ....................................................2 mgMolybdenum (Citrate) ..............................................25 mcgSilicon (Dioxide) .....................................................2.5 mcgVanadium (Citrate) ....................................................5 mcgBoron (Sodium borate) ...........................................100 mcgPhosphorus (Dicalcium phosphate)……………...78.64 mgOther Supporting Nutrients:Cranberry…………………………….….…….......12.5 mg(Vaccinium macrocarpon, berries)Lutein ……………….………………….………...150 mcg*Hydrolyzed Vegetable ProteinEXCIPIENTSCellulose, Vegetable Magnesium Stearate, Water-SolubleCellulose, Titanium Dioxide, Natural Carmine.For Professional Use OnlyThe information contained here has been accumulated from many sources.Indications are not intended as cures, they are simply a guideline to be used at your professional discretion.For more information please visit www.jamiesonvitamins.com or call 1-800-265-5088 to speak to a Consumer Affairs representative.10/25/11

DIRECTIONSAdults: Take 2 capsules daily with a meal. Take a fewhours before or after taking other medications. Storebetween 15°-25°C, away from children.INDICATED BENEFITS• Helps maintain optimal health by supporting dailymetabolic processes• Supplies essential nutrients that may be missingfrom the diet• Provides natural antioxidant support and optimizesthe natural defense system of the body• Supports bone, breast and urinary tract healthNUTRIENT INTERACTIONSConsult a healthcare practitioner prior to use aboutpotential interactions that could occur between thismultivitamin-mineral formula and any medications thatyou are currently taking. Take this product a few hoursbefore or after any other medications.WARNINGS AND PRECAUTIONSFor adult use only. Consult a healthcare practitioner priorto use if you are pregnant or breastfeeding; if you aretaking blood thinners; if you have a history of kidneystones. Keep out of the reach of children. There isenough iron in this package to seriously harm a child.TOXICITY, ADVERSE REACTIONS, ANDSIDE EFFECTSNone known when taken as directed.REFERENCES1. McCoubrey, H., Parkes, G., Sanderson, J. and Lomer, M.(2008), Nutritional intakes in irritable bowel syndrome. JHum Nutr Diet. 21: 396–397.2. Fletcher RH & Fairfield KM. Vitamins for chronic diseaseprevention in adults: clinical applications. JAMA. 2002;287(23): 3127-29.3. Schroeder, HA. (1971). Losses of vitmains and traceminerals resulting from processing and preservation offoods. Am J Clin Nutr. 24: 562-573.4. Pineo, GF, Gallus, AS, Hirsh, J. (1973). Unexpectedvitamin K deficiency in hospitalized patients. CMAJ.3(109): 880-883.5. Hosseinpanah F, Pour SH, Heibatollahi M, Moghbel N,Asefzade S, Azizi F. (2010). BMC Public Health. 29;10:519.6. Mangas, Sotirios, and Samir Samman. (2001). Review paper:Potential essentiality of boron: a ubiquitous dietaryconstituent. Austraila J Nutr & Dietetics. 58.2: 104-106.7. Rainey CJ, Nyquist LA, Christensen RE, Strong PL, CulverBD, & Coughlin JR. (1999). Daily boron intake from theAmerican diet. J Am Diet Assoc. 99(3):335-40.8. Nick, Gina L. (2005). Vitamin K and Bone Health.Townsend Letter for Doctors and Patients. 261: 39(2).9. Gibson R.S. (2006) Principles of nutritional assessment.Oxford University Press. New York NY.10. Sommerburg O, Keunen JE, Bird AC, van Kuijk FJ. (1998).Fruits and vegetables that are sources for lutein andzeaxanthin: the macular pigment in human eyes. Br JOphthalmol. 82(8):907-10.11. Semes L. (2009). Lutein, the natural protector: thiscarotenoid goes to battle against AMD and other eyediseases. Review of Optometry 146.8: 46(2).12. Bartlett, HE and Eperjesi. (2007). Effect of lutein andantioxidant dietary supplementation on contrast sensitivityin age-related macular disease: a randomized controlledtrial. Eur J Clin Nutr. 61.9: 1121-1127.13. Vondracek SF. (2010). Managing Osteoporosis inpostmenopausal women. Am J Health Syst Pharm. 67.7:S9-S19.14. Health Canada Vitamin D and Calcium: Updated DietaryReference Intakes http://www.hc-sc.gc.ca/fnan/nutrition/vitamin/vita-d-eng.php15. Holick, MF. (2002). Vitamin D: the underappreciated D-lightful hormone that is important for skeletal and cellularhealth. Curr Opin Endocrinol Diabetes. 9(1): 87-98.16. Garland CF, Garland FC, Gorham ED, Lipkin M, NewmarkH, Mohr SB & Holick MF. The role of vitamin D in cancerprevention. Am J Pub Health. 2006 Feb; 96(2): 252-61.17. Lappe JM, Travers-Gustafson D, Davies KM, Recker RR &Heaney RP. Vitamin D and calcium supplementationreduces cancer risk: results of a randomized trial. Am J ClinNutr. 2007; 85(6): 1586-91.18. IOM 2011: Institute of Medicine. (2011). Ross CA, TaylorCL, Yaktine AL, Del Vallee HB, editors. Institute ofMedicine. Dietary Reference Intakes: The Essential Guide toNutrient Requirements. Washington (DC): NationalAcademies Press. Dietary Recommended Intakes.For Accidental Overdose (such as child ingesting formula)Dial 911, 0 for operator assistance or call your nearest Poison Control Centre.For Professional Use OnlyThe information contained here has been accumulated from many sources.Indications are not intended as cures, they are simply a guideline to be used at your professional discretion.For more information please visit www.jamiesonvitamins.com or call 1-800-265-5088 to speak to a Consumer Affairs representative.10/25/11

19. Urinary Tract Infection. accessed:http://www.medicinenet.com/urine_infection/article.htm20. Pinzon-Arango PA, Yatao L, & Camesano TA. (2009).Role of cranberry on bacterial adhesion forces andimplications for Escherichia coli – uroepithelial cellattachment. J Med Food. 12.2: 259(12).21. Cranberry accessed:http://www.umm.edu/altmed/articles/cranberry-000235.htm22. National Institutes of Health. Dietary Supplement FactSheet: Iron. http://ods.od.nih.gov/factsheets/Iron-HealthProfessional/23. IOM 1998: Institute of Medicine. Panel on Folate, other BVitamins, and Choline and Subcommittee on UpperReference Levels of Nutrients, and the StandingCommittee on the Scientific Evaluation of DietaryReference Intakes, Food and Nutrition Board, Institute ofMedicine. Dietary Reference Intakes for Thiamin,Riboflavin, Niacin, Vitamin B 6 , Folate, Vitamin B 12 ,Pantothenic Acid, Biotin and Choline. National AcademyPress.24. National Institutes of Health. Dietary Supplement FactSheet: Vitamin B12.http://ods.od.nih.gov/factsheets/VitaminB12-Consumer/For Accidental Overdose (such as child ingesting formula)Dial 911, 0 for operator assistance or call your nearest Poison Control Centre.For Professional Use OnlyThe information contained here has been accumulated from many sources.Indications are not intended as cures, they are simply a guideline to be used at your professional discretion.For more information please visit www.jamiesonvitamins.com or call 1-800-265-5088 to speak to a Consumer Affairs representative.10/25/11