Collagen Glucosamine Complex monograph.pdf - Jamieson

COLLAGEN GLUCOSAMINECOMPLEXUPC CODE 0 646420 6345 8EN#155442NATURAL HEALTH PRODUCTSDIRECTORATE (NHPD) CLAIMS:NHPD claim pending for Jamieson CollagenGlucosamine Complex is:• Helps to relieve joint pain associated withosteoarthritis.Product DetailsCollagen Glucosamine Complex is made with UC-II ®Collagen which consists of undenatured (native) type IIcollagen, a new dietary ingredient that promotes healthyjoints and increases joint mobility and flexibility. 1 ThisComplex also contains Glucosamine, Vitamin C andMagnesium which supports bone and muscle function aswell as collagen formation.GENERAL INFORMATIONOsteoarthritisOsteoarthritis (OA) is a progressive disease involving allthe structural elements of the articulating joint 2 , and thisdisorder affects many aging Canadians. 2 OA ischaracterized by the destruction of articular cartilage andsubchondral bone. 3 The two most affected joints in adultsare the hips and knees. 3 Often, the last option to correctthis problem is joint replacement surgery. 2,3In the case of OA, when cartilage is damaged, the bodybelieves that a foreign invader has infiltrated the affectedjoint. 4 The lymph nodes signal the release of collagenspecific T and B cells that accelerate type II collagenbreakdown. 4 The degradation of cartilage in OA is causedby zinc metalloproteinases enzymes. 4 In many patients,OA remains stable for a long period of time beforeprogressing to its more debilitating form. 2 The mostcommon symptoms of OA are pain and loss of jointfunction. 2Until recently, most treatments for OA focused onrelieving the symptoms of the disease. However, duringthe past decade, efforts have been made in thedevelopment of molecules that can stop or slow down thestructural bone and cartilage damage caused by thisdisorder. 2CollagenCollagen is a group of naturally occurring proteins foundonly in the flesh and connective tissues of animals. 7Connective tissue is one of the four types of body tissueswhose primary role is to bind other tissue systems (such asmuscle and skin) or organs together. 5 Most of connectivetissue is made of collagen, and this latter protein makes upmost (25-35%) of the body’s protein content. 6A collagen molecule is unique in that it is an insolubleprotein. 6 Also, its three linear coiled chains are made ofregularly arranged amino acids. 6 Collagen moleculesaggregate to form collagen microfibrils. 6 Microfibrils arethen orderly interconnected to make very stable collagenfibrils. 6 Finally, bundles of fibrils are assembled to createtough collagen fibers that have great tensile strength. 6The two major components of articular cartilage iscollagen type II and aggrecan, a large protein linked tocarbohydrates. Collagen II gives cartilage its tensilestrength and aggrecan provides its weight-bearingproperties. 6,7Collagen-related diseases are usually the consequence ofgenetic defects or nutritional deficiencies (i.e. vitamin C)that affect the many steps of normal collagen production. 6In an attempt to identify better treatments for OA, studiesof hydrolyzed or denatured type II collagen were done atHarvard Medical School. 8 According to the Harvardresearchers, this type of collagen had no observable effecton the incidence and severity of OA. 8UC-II ® CollagenUC-II ® Collagen consists of undenatured (native) type IIcollagen, a new dietary ingredient that promotes healthyjoints and increases joint mobility and flexibility. 9 Thiskind of collagen is derived from purified, pharmaceuticallypure chicken sternum cartilage sourced from the UnitedStates. UC-II ® Collagen is the only source of undenaturedtype II collagen available as a dietary ingredient. 1For Accidental Overdose (such as child ingesting formula)Dial 911, 0 for operator assistance or call your nearest Poison Control Centre.For Professional Use OnlyThe information contained here has been accumulated from many sources.Indications are not intended as cures, they are simply a guideline to be used at your professional discretion.For more information please visit www.jamiesonvitamins.com or call 1-800-265-5088 to speak to a Consumer Affairs representative02/28/11

UC-II ® Collagen promotes healthy joints by working withthe immune system to deactivate collagen-specific T-cells. 4 The deactivation of collagen-specific T-cellsprevents the secretion of collagenase enzymes, whichbreak down the collagen in the joint. Because the T-cellsare no longer attacking the joints, 1 UC-II ® Collagen canhelp the immune system maintain normal joint functionand healthy collagen formation with lasting benefits. 1In a randomized, double-blind, clinical study, 40 mg ofUC-II ® Collagen was more than twice as effective as1,500 mg of glucosamine and 1,200 mg of chondroitin inpromoting complete joint health. 9UC-II ® Collagen was also shown to improve quality oflife. 9 UC-II ® Collagen significantly decreased pain duringdaily activities, including walking on a flat surface,performing heavy domestic duties, ascending stairs andwhile resting in bed. 9GlucosamineGlucosamine is a biological chemical that is naturallypresent in bone cartilage, where it forms the majorcushioning ingredients of the synovial fluids of the jointsand surrounding tissues. 10 As its name indicates,glucosamine is composed of a sugar molecule (glucose)and an amine group. 11 While most sugars come fromdietary sources and are burned for energy, amino sugarsare mainly formed in the body and used primarily inmanufacturing tissue components. 11 As such, glucosaminehelps form the proteoglycans that fit within the spaces incartilage netting that is needed to restore jointstructure. 10,11Normal wear and tear during bodily functions means thattissues are constantly broken down (metabolized) andreplaced or restructured. Glucosamine amino sugars arethus continuously in demand. With age, the body’s abilityto produce glucosamine may become impaired, resulting inconsiderable dysfunction and pain. 11 Therefore,glucosamine metabolism is an important factor to considerin the development of osteoarthritis (OA). 11 As a “buildingblock” of cartilage, glucosamine can help to slow thedevelopment of mild to moderate OA by protecting andstrengthening cartilage, allowing it to retain its cushioningeffects and lubricate the joints. 11 It also plays a role inpreventing further joint damage, helps to reduceinflammation and supports pain-free movement of thejoints. 10,11Vitamin C and MagnesiumCollagen Glucosamine Complex also contains Vitamin Cand Magnesium, and each one has a unique role insupporting bone and muscle function as well as collagenformation.Vitamin C is required for synthesizing collagen andchondroitin sulfate, which are structural and cementingmaterials of the body. 12,13 It is required to produce elastin, asubstance that keeps arteries strong. 12,13 In addition,vitamin C helps to synthesize mucopolysaccharides,substances in which our cells are embedded. 12,13,14,15Approximately half of the magnesium in the body is foundin the bones and it is an essential nutrient to keep themstrong and healthy. 16 Magnesium also plays an importantrole in maintaining the function of nerves and regulatingmuscle relaxation. 16When undenatured type II collagen, glucosamine, vitaminC and magnesium are combined, a superior and synergisticjoint-relieving product is created. Collagen GlucosamineComplex prevents and helps repair joint damage.Consequently, this Complex has a positive effect on jointflexibility, mobility, and quality of life .Jamieson Collagen Glucosamine Complex is formulatedfrom natural sources and is pharmaceutically tested toguarantee full potency and absolute clinical purity.What makes Collagen Glucosamine Complex fromJamieson Laboratories different…and why doesthat difference mean better?1) UC-II ® Collagen consists of undenatured (native) typeII collagen, a new dietary ingredient sourced from theUnited States that promotes healthy joints andincreases joint mobility and flexibility. 92) It combines four key nutritional ingredients attherapeutic levels, in a “one-a-day formula”.3) Our premium formulations are manufactured using the360 Pure process – a minimum of 360 quality teststhat guarantee traceability and reliability of rawFor Accidental Overdose (such as child ingesting formula)Dial 911, 0 for operator assistance or call your nearest Poison Control Centre.For Professional Use OnlyThe information contained here has been accumulated from many sources.Indications are not intended as cures, they are simply a guideline to be used at your professional discretion.For more information please visit www.jamiesonvitamins.com or call 1-800-265-5088 to speak to a Consumer Affairs representative02/28/11

material, product safety, full potency and absoluteclinical purity.INGREDIENT INFORMATIONAvailable as 30 capsules.Each capsule contains :UC II ® Collagen ……………………………...……...40 mg(Undenatured Type II Collagen from Chicken SternumCartilage)Glucosamine Sulfate KCl…………………………100 mg(Aspergillus niger, chitin from fermented corn)Magnesium (Oxide)…...………………………….....20 mgVitamin C (Ascorbic acid)………………………….10 mgEXCIPIENTSCellulose, Calcium Phosphate, Vegetable MagnesiumStearate, Silica, Potassium Chloride, Gelatin.DIRECTIONSAdults: Take one capsule daily. Store between 15°C-25°C away from children.INDICATED BENEFITS• Helps to relieve joint pain associated with osteoarthritisNUTRIENT INTERACTIONSDrug InteractionsNone known when taken as directed.Nutrient DepletionsNone known when taken as directed.Supportive InteractionsNone known when taken as directed.WARNINGS AND PRECAUTIONSNone known when taken as directed.TOXICITY, ADVERSE REACTIONS, ANDSIDE EFFECTSNone known when taken as directed.REFERENCES1. InterHealth Nutraceuticals Incorporatedhttp://www.interhealthusa.com/Ingredients/UC-II®.aspx2. Rogerson, Fraser M. "Cartilage matrix degradation: anappropriate therapeutic target in osteoarthritis."Therapy 7.6 (2010): 579(4).3. Reginster, Jean-Yves, et al. "Oral calcitonin in themanagement of osteoarthritis: hope or fantasy?"International Journal of Clinical Rheumatology 5.1(2010): 53(6).4. Bagchi D, Misner B, Bagchi M, et al. Effects of orallyadministered undenatured type II collagen againstarthritic inflammatory diseases: A mechanisticexploration. Int J Clin Pharmacol Res. 2002; 22:101-110.5. Embryonic and Ordinary Connective Tissue availableat:http://kentsimmons.uwinnipeg.ca/cm1504/15lab42006/lb4pg6.htm6. Fratz, P. (2008). Collagen Structure and Mechanics.New York NY: Springer7. Reginster, Jean-Yves, et al. "Oral calcitonin in themanagement of osteoarthritis: hope or fantasy?"International Journal of Clinical Rheumatology 5.1(2010): 53(6).8. Nagler-Anderson C, Bober LA, Robinson ME, SiskindGW, Thorbecke GJ. Suppression of type II collageninducedarthritis by intragastric administration ofsoluble type II collagen. Proc Natl Acad of Sci U S A.1986; 83:7443-7446.9. Crowley DC, Lau FC, Sharma P, et al. Safety andefficacy of undenatured type II collagen in theFor Accidental Overdose (such as child ingesting formula)Dial 911, 0 for operator assistance or call your nearest Poison Control Centre.For Professional Use OnlyThe information contained here has been accumulated from many sources.Indications are not intended as cures, they are simply a guideline to be used at your professional discretion.For more information please visit www.jamiesonvitamins.com or call 1-800-265-5088 to speak to a Consumer Affairs representative02/28/11

treatment of osteoarthritis of the knee: a clinical trial.Int J Med Sci. 2009; 6:312-321.10. Braham, R., Dawson, B., Goodman, C. (2003). Theeffect of glucosamine supplementation on peopleexperiencing regular knee pain. British Journal ofSports Medicine, 37:45-49.11. Towheed, T.E., Anastassiades, T. (2007).Glucosamine therapy for osteoarthritis: An update. TheJournal of Rheumatology, 34(9):1787-1790.12. Groff, J., Gropper, S. (2000). Advanced Nutrition andHuman Metabolism, 3rd edition. Belmont (CA):Wadsworth/Thomson Learning.13. Otten, J.J., Pitzi Hellwig, J., Meyers, L.D. editors.(2006). IOM 2006: Institute of Medicine. Institute ofMedicine. Dietary Reference Intakes: The EssentialGuide to Nutrient Requirements. Washington (DC):National Academies Press; 2006.14. IOM 2000: Institute of Medicine. Food and NutritionBoard, Institute of Medicine. Dietary Reference Intakesfor Vitamin C, Vitamin E, Selenium and Carotenoids.A Report of the Panel on Dietary Antioxidants andRelated Compounds, Subcommittees on UpperReference Levels of Nutrients and Interpretation andUses of Dietary Reference Intakes, and the StandingCommittee on the Scientific Evaluation of DietaryReference Intakes. Washington (DC): NationalAcademies Press; 2000.15. Shils, M.E., Olson, J.A., Shike, M., Ross, A.C., editors.(2006). Modern Nutrition in Health and Disease, 10thedition. Philadelphia (PA): Lippincott Williams andWilkins.16. Fox, Chester, Delano Ramsoomair, and CathleenCarter. "Magnesium: Its proven and potential clinicalsignificance.(Statistical Data Included)." SouthernMedical Journal 94.12 (2001): 1195(7).For Accidental Overdose (such as child ingesting formula)Dial 911, 0 for operator assistance or call your nearest Poison Control Centre.For Professional Use OnlyThe information contained here has been accumulated from many sources.Indications are not intended as cures, they are simply a guideline to be used at your professional discretion.For more information please visit www.jamiesonvitamins.com or call 1-800-265-5088 to speak to a Consumer Affairs representative02/28/11