WTZ Cancer Center Director Univ. Prof. Dr. med. Angelika Eggert ...

2. Coordinator
Prof. Dr. med. Joachim Fandrey
Institute of Physiology
6. Selected Publications 2002-2008
Stolze I., Berchner-Pfannschmidt U., Freitag P., Frede S., Wotzlaw C., Acker H., Fandrey J. (2002).
Hypoxia inducible erythropoitin gene expression in human neuroblastoma cells.
Blood 100: 2623-2628. IF 10,1
Shibata J., Hasegawa J., Siemens H.-J., Wolber E.M., Dibbelt L., Li D., Katschinski D.M.,
Fandrey J., Jelkmann W., Gassmann M., Wenger R.H., Wagner K.F. (2003). Hemostasis and
coagulation at a hematocrit of 0.85: functional consequences of erythrocytosis.
Blood 101: 4416-4422 IF 10,1
Metzen E., Berchner-Pfannschmidt U., Stengel P., Marxen J.H., Stolze I., Klinger M., Huang W.Q.,
Wotzlaw C., Hellwig-Bügel T., Jelkmann W., Acker H., Fandrey J. (2003). Intracellular localisation
of human HIF-1 alpha hydroxylase: implications for oxygen sensing.
J Cell Sci. 116: 1319-26 IF 6,9
Liu Q., Berchner-Pfannschmidt U., Möller U., Brecht M., Wotzlaw C., Acker H., Jungermann K.,
Kietzmann T. (2004). A Fenton reaction at the endoplasmic reticulum is involved in the redox
control of hypoxia-inducible gene expression.
Proc Natl Acad Sci USA 101: 4302-7 IF 10,5
Berchner-Pfannschmidt U., Petrat F., Doege K., Trinidad B., Freitag P., Metzen E., de Groot H.,
Fandrey J. (2004). Chelation of cellular calcium modulates hypoxia-inducible gene expression
through activation of Hypoxia-Inducible Factor-1 alpha.
J Biol Chem. 279: 44976-44986. IF 6,4
Frede, S., Freitag, P., Otto, T., Heilmaier, C., Fandrey, J. (2005). The proinflammatory cytokine IL-
1β and hypoxia cooperatively induce the expression of adrenomedullin in ovarian carcinoma cells
through HIF-1 activation.
Canc. Res. 65:4690-4697 IF 8,6
Wotzlaw C, Otto T, Berchner-Pfannschmidt U, Metzen E, Acker H, Fandrey J (2007). Optical
analysis of the HIF-1 complex in living cells by FRET and FRAP.
FASEB J. 21: 700-707 IF 6,7
Berchner-Pfannschmidt U, Yamac H, Trinidad B, Fandrey J. (2007) Nitric oxide modulates oxygen
sensing by hypoxia-inducible factor 1-dependent induction of prolyl hydroxylase 2.
J Biol Chem. 282:1788-96. IF 6,4
Otto T, Fandrey J (2008). Thyroid hormone induces Hypoxia Inducible Factor 1{alpha} gene
expression through TR{beta}/RXR{alpha} dependent activation of Hepatic Leukemia Factor.
Endocrinology 149:2241-50 IF 5,2