WTZ Cancer Center Director Univ. Prof. Dr. med. Angelika Eggert ...

2. Coordinator
Prof. Dr. rer. nat. Ralf Küppers
Institute for Cell Biology (Tumor Research)
6. Selected publications 2001-2008
Pasqualucci L, Neumeister P, Goossens T, Nanjangud G, Chaganti RSK, Küppers R, Dalla-Favera
R (2001) Hypermutation of multiple proto-oncogenes in B-cell diffuse large-cell lymphoma.
Nature, 412, 341- 346 IF 32.2
Schwering I, Bräuninger A, Klein U, Jungnickel B, Tinguely M, Diehl V, Hansmann M-L, Dalla-
Favera R, Rajewsky K, Küppers R (2003) Loss of the B lineage-specific gene expression program
in Hodgkin and Reed/Sternberg cells of Hodgkin’s lymphoma.
Blood, 101, 1505-1512 (IF: 9.8) IF 10.4
Küppers R, Klein U, Schwering I, Distler V, Bräuninger A, Cattoretti G, Tu Y, Stolovitzky GA,
Califano A, Hansmann M-L, Dalla-Favera R (2003) Identification of Hodgkin and Reed-Sternberg
cell-specific genes by gene expression profiling.
J. Clin. Invest., 111, 529-537 IF 15.0
Kurth J, Hansmann M-L, Rajewsky K, Küppers R (2003) Epstein-Barr virus-infected B cells
expanding in germinal centers of infectious mononucleosis patients do not participate in the
germinal center reaction.
Proc. Natl. Acad. Sci. USA, 100, 4730-4735 IF 10.5
Küppers R (2003) B cells under influence: transformation of B cells by Epstein-Barr virus.
Nature Rev. Immunol. 3, 801-812 IF 30.5
Messer, R.J., Dittmer, U., Peterson, K.E. & Hasenkrug, K.J. (2004) Essential roles for
virus-neutralizing antibodies in sterilizing immunity against Friend retrovirus infection.
Proc. Nat. Acad. Sci. USA 101:12260- 12265. IF 10.4
Dittmer, U., He, H., Messer R.J., Schimmer, S., Olbrich, A.R.M., Ohlen, C., Greenberg P.D.,
Stromnes I.M., Iwashiro M., Sakaguchi S., Evans L.H., Peterson K.E., Yang, G. & Hasenkrug K.J.
(2004) Functional impairment of CD8+ T cells by regulatory T cells during persistent retroviral
infection.
Immunity 20:293- 303. IF 15.4
Bechtel D, Kurth J, Unkel C, Küppers R (2005) Transformation of BCR-deficient germinal-center
B cells by EBV supports a major role of the virus in the pathogenesis of Hodgkin and
posttransplantation lymphoma.
Blood, 106, 4345-4350 IF 10.4
Küppers R (2005) Mechanisms of B cell lymphoma pathogenesis.
Nature Rev. Cancer, 5, 251-262 IF 31.7
Kraft, A.R.M., Krux, F., Schimmer, S., Ohlen, C., Greenberg, P.D. & Dittmer, U. (2007) CpG
oligodeoxynucleotides allow for effective adoptive T-cell therapy in chronic retroviral infection.
Blood 109:2982-2984. IF 10.1
Balkow, S., Krux, F., Loser, K., Becker, J.U., Grabbe, S. & Dittmer, U. (2007) Friend retrovirus
infection of myeloid dendritic cells impairs maturation, prolongs contact to naïve T cells, and favors
expansion of regulatory T cells.
Blood 110:3949-3958. IF 10.1