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Ire1p is an inner nuclear membrane protein with itsN-terminal domain in the ER lumen, and its C-terminal domain in the nucleus.Binding of an unfolded protein to the N-terminaldomain activates the C-terminal nuclease byautophosphorylation.The activated nuclease cleaves Hac1 m<strong>RNA</strong> torelease an intron and generate exons that are ligatedby a t<strong>RNA</strong> ligase.The spliced Hac1 m<strong>RNA</strong> codes for a transcriptionfactor that activates genes coding for chaperonesthat help to fold unfolded proteins.Figure 24.31 The unfolded protein response occurs by activatingspecial splicing of HAC1 m<strong>RNA</strong> to produce a transcription factorthat recognizes the UPRE.B-38
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