VIRAL INFECTION - Faculty of Medicine

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Measles virus• Clinical:- conjunctivitis, cough, coryza, fever- at day 2-3: “Koplik spot” at buccalmucosa- at day 4-5: reddish-brown rash,enlarged cervical LN- 1 week: subsidePathology of Measles• Multinucleated giantcells with intranuclearand intracytoplasmicinclusion (Warthin-Finkeldey cells) inlymphoid organs andother organsWarthin-Finkeldey cellsMeasles virus• Complication:- pneumonia- encephalitis- keratitis- abnormal hemorrhage- secondary bacterial infectionRubella (german measles)• Caused by Rubella virus• Incubation period 14-21 days• Systemic infection : rash, fever, malaise,coryza, arthritis and arthralgias• Exanthem - discrete, pinkish red, finemaculopapular eruption - begins on theface and spreads cephalocaudally• Dx: serology testingMeaslesRubella (german measles)Koplik spot
Congenital rubella syndrome• Infected pregnant woman ( first 20 th wks)• Fetal death, premature delivery, congenitalanomalies• Heart defects: PDA, VSD, pulmonaryvalvular stenosis• Eye and ear defects: cataract, glaucoma,deafness• CNS defects: microcephaly, mental retardHerpes simplex infectionTransmitted by direct/sexual contactDiagnosis: clinicallyscrap base of vesicle and a specialstain - Giemsa-stained (Tzanck smear)ballooned epithelial cells with intranuclearinclusions and multinucleated giantviral cultures take 24-72 hoursRubella (german measles)Primary herpes simplex infections• Complications - arthritis, purpura,thrombocytopenia, encephalitisHerpetic gingivostomatitishigh fever, irritability, anorexia, mouth pain,drooling in infants and toddlersgingiva becomes intensely erythematous,edematous, friable and tends to bleedsmall yellow ulcerations with red halos seen onbuccal and labial mucosa, tongue, gingivae,palate, tonsilsHerpes simplex infectionsPrimary herpes simplex infectionsHSV-1>90% of primary infections aresubclinicalFever blister or cold sores at facialskin eg. lip, nose, gingivostomatitisHSV-2genital pathogenneonatal herpesHSV-1 Cold soreSkin infectionsfever, malaise, localized lesionsdirect inoculation (usually cold sores) andgenitaliapainful vesicles on erythematous base -usually groupedHSV-2 Genital Herpes
Page 3: Influenza Antigenic Changes• Anti
Page 12 and 13: Recurrent herpes simplex infectionH
Page 14 and 15: Herpes zoster (shingles)Varicella (
Page 16 and 17: Cytomegalovirus (CMV)• Produce a
Page 18 and 19: Human Immunodeficiency Virus(HIV)
Page 20 and 21: Human papilloma virus (HPV)• Most
Page 22 and 23: Intracytoplasmic inclusion bodies(m

VIRAL INFECTION - Faculty of Medicine

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