VIRAL INFECTION - Faculty of Medicine
VIRAL INFECTION - Faculty of Medicine
VIRAL INFECTION - Faculty of Medicine
You also want an ePaper? Increase the reach of your titles
YUMPU automatically turns print PDFs into web optimized ePapers that Google loves.
Herpes zoster (shingles)Varicella (chickenpox)After primary infection, virus lies dormantin genome <strong>of</strong> sensory nerve root cellPostulated triggers include mechanicaland trauma, infection, immunosuppressionLesions are grouped, thin-walled vesicleson erythematous base distributed alongdermatomelesions in multi-stagesPathogenesis <strong>of</strong> VZVShinglesPrimary infection ( chickenpox)VZV spread from mucosal and epidermal lesionsto local sensory nervesVZV remains latent in dorsal ganglion cells <strong>of</strong>sensory nervesReactivation <strong>of</strong> VZV results in syndrome <strong>of</strong> herpeszoster (shingles)Varicella zoster virus (VZV)Shingles• Gross:- chickenpox: diffuse, scattered vesicles- shingles: vesicles distribution along theperipheral nerve (dermatome)• Histology:- Intranuclear inclusion <strong>of</strong> infected cells(multinucleated cells)
Change language