VIRAL INFECTION - Faculty of Medicine
VIRAL INFECTION - Faculty of Medicine
VIRAL INFECTION - Faculty of Medicine
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Cytomegalovirus (CMV)• Produce a variety <strong>of</strong> disease dependon age, immune status• Cause <strong>of</strong> asymptomatic in healthyperson or severe systemic infection inneonates and immunocompromisedhost (opportunistic infection)Histology <strong>of</strong> CMV• Large purple intranuclear inclusionsurrounded by clear halo and smallerbasophilic intracytoplasmic inclusion• Organ involvement: salivary glands,kidney, liver, pancreas, brain, ect.Cytomegalovirus (CMV)CMV• Transmitted by:- intrauterine transmission- perinatal transmission- breast milk- respiratory droplets- semen and vaginal fluid- blood transfusion- organs transplantationCytomegalovirus (CMV)• Clinical feature depends on infectedorgans• Congenital CMV infection– 90% asymptomatic– 10% symptomatic eg. hemolytic anemia,jaundice, thrombocytopenia, pneumonia,hepatosplenomegaly, retinitis, brain damage,mental retard or deadEpstein-Barr Virus (EBV)• Cause <strong>of</strong> infectious mononucleosis• Self-limiting illness <strong>of</strong> children & young• EBV associated with hairy leukoplakia,lymphoma, and nasopharyngealcarcinoma• Transmitted by contact saliva
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