Ovarian Cancer: Genetic Counseling and Testing, Screening and ...

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Breast Cancer Risk Post-BPO in pre-menopausal womenwho use short term Hormone Replacement Therapy (HRT)HRT after oophorectomyBreast Ca Risk ReductionNone 62%Any 63%Estrogen Alone 56%Estrogen + Progesterone 57%Rebbeck et al, JCO 2005
Other Benefits of Prophylactic Oophorectomy inBRCA1/2 Mutation CarriersBreast Cancer MortalityOvarian Cancer MortalityOverall Mortality90% reduction95% reduction76% reductionDomchek et al, Lancet Oncology 2006
Page 1 and 2: Ovarian Cancer: Genetic Counseling
Page 3 and 4: Family History of Ovarian Cancer•
Page 5 and 6: BRCA1-Associated Associated Cancers
Page 7 and 8: BRCA2-Associated Associated Cancers
Page 9 and 10: Clinical Management ofBRCA Mutation
Page 11 and 12: BR 51Stom 53 Brain 50Liver 72BR 29B
Page 13 and 14: BR 51OV 53 Brain 50OV 72B1POSB1NEGB
Page 15: Risk Reduction from removing ovarie
Page 19 and 20: BRCA1 familyProstate 60Colon 60B1B1
Page 21 and 22: Features That Indicate IncreasedLik
Page 23 and 24: Amsterdam Criteria• 3 or more rel
Page 25 and 26: Genetic Testing forCancer Susceptib
Page 27 and 28: Genetic Testing for Cancer Risk•
Page 29: Concerns regarding discrimination

Ovarian Cancer: Genetic Counseling and Testing, Screening and ...

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