Ovarian Cancer: Genetic Counseling and Testing, Screening and ...

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Lynch Syndrome – also called HereditaryNon-Polyposis Colorectal <strong>Cancer</strong> (HNPCC)• Colon cancer risk – 80% risk• Extracolonic cancers:• Endometrium: : 40-60% risk• Ovary: 10% risk• Less than 10% risk: : stomach, urinary tract,small bowel, bile ducts, pancreas, sebaceousskin tumors
Amsterdam Criteria• 3 or more relatives with verified CRC in family• One case a first-degree relative of the other two• Two or more generations• One CRC by age 50• FAP excludedFailure to meet these criteriadoes not exclude HNPCCVasen HFA et al. Dis Colon Rect 34:424, 1991
Page 1 and 2: Ovarian Cancer: Genetic Counseling
Page 3 and 4: Family History of Ovarian Cancer•
Page 5 and 6: BRCA1-Associated Associated Cancers
Page 7 and 8: BRCA2-Associated Associated Cancers
Page 9 and 10: Clinical Management ofBRCA Mutation
Page 11 and 12: BR 51Stom 53 Brain 50Liver 72BR 29B
Page 13 and 14: BR 51OV 53 Brain 50OV 72B1POSB1NEGB
Page 15 and 16: Risk Reduction from removing ovarie
Page 17 and 18: Other Benefits of Prophylactic Ooph
Page 19 and 20: BRCA1 familyProstate 60Colon 60B1B1
Page 21: Features That Indicate IncreasedLik
Page 25 and 26: Genetic Testing forCancer Susceptib
Page 27 and 28: Genetic Testing for Cancer Risk•
Page 29: Concerns regarding discrimination

Ovarian Cancer: Genetic Counseling and Testing, Screening and ...

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