Ovarian Cancer: Genetic Counseling and Testing, Screening and ...

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Hereditary Risk for Ovarian Cancer• Single gene conferring significant risk• BRCA1 and BRCA2• Lynch Syndrome (MLH1,(MSH2, MSH6, PMS2)
BRCA1-Associated Associated Cancers:Lifetime RiskBreast cancer 60%−80% (often early age at onset)Second primary breast cancer 40%−60%Ovarian cancer 30-45% Slightly increased risk ofUterine and Cervical cancerIncreased risk of other cancers:Colon: : 10-15%15%Male breast cancer: : 1-5% 1Pancreatic 2-3%
Page 1 and 2: Ovarian Cancer: Genetic Counseling
Page 3: Family History of Ovarian Cancer•
Page 7 and 8: BRCA2-Associated Associated Cancers
Page 9 and 10: Clinical Management ofBRCA Mutation
Page 11 and 12: BR 51Stom 53 Brain 50Liver 72BR 29B
Page 13 and 14: BR 51OV 53 Brain 50OV 72B1POSB1NEGB
Page 15 and 16: Risk Reduction from removing ovarie
Page 17 and 18: Other Benefits of Prophylactic Ooph
Page 19 and 20: BRCA1 familyProstate 60Colon 60B1B1
Page 21 and 22: Features That Indicate IncreasedLik
Page 23 and 24: Amsterdam Criteria• 3 or more rel
Page 25 and 26: Genetic Testing forCancer Susceptib
Page 27 and 28: Genetic Testing for Cancer Risk•
Page 29: Concerns regarding discrimination

Ovarian Cancer: Genetic Counseling and Testing, Screening and ...

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