Review the symposium abstracts (3.19MB PDF) - College of Science

Poster PresentationExploring the polymorphism of piperineBrianna ChamberlinAdvisor: Adam Matzger, Dept. of Department of Chemistry, University of MichiganPiperine, a component of Piper Longum, was studied to determine if the compound exhibitedpolymorphism, the ability of a crystalline material to form multiple unique packing structures.The discovery of novel crystalline forms is of great importance to the pharmaceutical industrydue to the effects unique molecular packing can have on the physiochemical properties of acompound. In addition, each form is a unique composition of matter leading to intellectualproperty implications. Polymorphic studies of piperine are especially intriguing because itexhibits low solubility in water and also qualities of a biomodulator. Therefore piperine can varythe bioavailability of another compound when administered simultaneously. Using polymerinducedheteronucleation (PIHn) and other crystallization techniques, three novel polymorphshave been discovered and one crystal structure has been determined. The crystal forms ofpiperine have been characterized by Raman spectroscopy, X-ray diffraction, and differentialscanning calorimetry.37