PDF, Patent Landscape Report on Atazanavir - WIPO

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A quickly-obtained overview of the contents of the initial (stage-one) clinical collection isprovided by this map, covering the 314 patent families that were retrieved by using clinicalnames to search in the title, abstracts, claims, and DWPI enhanced abstracts. All of thesedocuments contain one or more of the names Atazanavir, Reyataz or the BMS or CGPtesting names within a title, abstract, claims (i.e., a field that indicates the term is central tothe invention).ThemeScape® map algorithms operate on the DWPI enhanced abstracts (all in English) tofind relationships based on shared terminology, and cluster the documents according totheir terminology-relatedness. Each dot on the map represents one invention family, andeach is placed on the map only once. Density is conveyed by pseudo-altitude. The axes arearbitrary, but distance is a representation of relatedness or lack thereof.The map of the stage-one collection shows that there are many documents related tomethods and synthesis (snow-capped peak indicates high density) and that there are 3other general areas covering a) mechanisms of action and the use of combinations toattack more than one target, b) drug behavior in patients and management of dosage,especially in the face of susceptibility to cytochrome P-450 monooxygenase, and c)managing side effects in various organ systems, and usage of drug in different clinicalsettings.Figure 6. Stage-One Clinical CollectionMechanisms andCombinationsIndications andSide EffectsSynthesis&Kinetics, Dosage &Formulations12
STAGE TWO CLINICAL SEARCHTo be more comprehensive, it was necessary to search for clinical names in the description(specification) section of the document as well, though this opens the possibility of addingsignificant “noise” to the collection. Unlike the rather targeted result that was obtained fromsearching titles, abstracts, claims or enhanced abstracts, searching the description fieldwith the clinical names returned a 6-7 fold higher number of invention families (eitherInpadoc or DWPI families), but this retrieval was likely to include a high fraction ofdocuments outside the desired scope. To diagnose the quality of the collection, theThemeScape map below shows the Stage-One documents and the new documents addedby the Stage-Two search mixed together. There are large regions in the map where veryfew inventions of the Stage-One collection are located (areas outlined in yellow). If weassume Stage-One is an indicator of higher relevance, that means the relevance in Stage-One-poor areas of the map is questionable. It is clear that the documents retrieved bysearching the description need to be reviewed to remove those that are not truly orientedtoward Atazanavir development. This is where use of either classification codes or otherfiltering methods becomes critical.Figure 7. Stage-Two Clinical Collection – Map shows collection improvement is needed13
Page 4 and 5: ContentsSECTION 1: THE TWO OBJECTIV
Page 7 and 8: collection for nuggets of intellige
Page 9 and 10: CHEMICAL NAMINGChemical naming conv
Page 11 and 12: Figure 2: Legal Status for Novartis
Page 13: name, but after the patent protecti
Page 17 and 18: CLINICAL COLLECTIONThis is an examp
Page 19 and 20: THE FOUNDER PATENT AND ITS DOWNSTRE
Page 21 and 22: CHEMICAL COLLECTIONThis is an examp
Page 23 and 24: SECTION 5: GENERAL OVERVIEW OF THE
Page 25 and 26: FAMILY MEMBER COUNTRIESLooking at p
Page 27 and 28: The crossover between categories is
Page 29 and 30: THE DEVELOPER’S OWN TIMELINEThe A
Page 31 and 32: Several of the representative paten
Page 33 and 34: Figure 25. Emphasis Matrix for Sele
Page 35 and 36: PATENT QUALITY INDICATORS FOR SELEC
Page 37 and 38: Figure 30. References made by the F
Page 39 and 40: FORMULATIONSEven before a drug is a
Page 41 and 42: Figure 34. References to Bristol My
Page 43 and 44: PROPRIETARY DRUGS AND LITIGATIONThe
Page 45 and 46: TWO DRUGS DIRECTED AT THE SAME TARG
Page 47 and 48: Citations to this document mainly c
Page 49 and 50: USING OVERLAP TO FIND COMBINATIONS
Page 51 and 52: INTERNATIONAL PATENT CLASSIFICATION
Page 53 and 54: ased on the IPC, but with sometimes
Page 55 and 56: DERWENT MANUAL CODESDWPI Manual Cod
Page 58: For more information contact WIPO a

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