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PIPELINEThe Burrill Report❱❱ (continued)Patents Announced in September 2012COMPANY TICKER COMPANY DESCRIPTION GRANTINGAGENCYButamax AdvancedBiofuelsPrivateA joint venture betweenBP and DuPont formed todevelop and commercializebiobutanol as a next generationrenewable biofuel for thetransport marketU.S. Patent andTrademark OfficePATENT NUM-BERU.S. Patent No.8,222,017PATENT COVERSPatent protects a subset of keyenzymes in the isobutanol productionpathway.Coronado BiosciencesNasdaq:CNDOA biopharmaceutical companyfocused on the developmentof novel immunotherapyagents for the treatment ofautoimmune diseases andcancerU.S. Patent andTrademark OfficeU.S. Patent No.8,257,970Patent covers CNDO-109 andmethod for activating natural killercells by tumor cell preparation invitro.Nuvo Research TSX: NRI A specialty pharmaceuticalcompany dedicated to buildinga portfolio of products forthe topical treatment of painU.S. Patent andTrademark OfficeU.S. Patent No.8,252,838Patent covers a product formulationthat, among other uses, assistsin weight loss and also the reductionof tobacco use.Aradigm CorporationOTCBB: ARDMA specialty pharmaceuticalcompany engaged in thedevelopment and commercializationof drugs deliveredby inhalation for the treatmentof severe respiratory diseasesU.S. Patent andTrademark OfficeU.S. Patent No.8,256,433The patent covers systems andmethods for effecting cessation oftobacco use. The company expectsthat the patent will provide exclusivityfor specific systems utilizinginhaled nicotine formulations untilJanuary 7, 2024.Histogen Private A regenerative medicine companydeveloping therapiesfor conditions including hairloss and cancerU.S. Patent andTrademark OfficeU.S. Patent No.8,257,947The patent, which is the company’sfirst patent issued in the UnitedStates, covers Histogen’s methodof growing cells under low oxygenand suspension conditions, andthe process through which thenaturally-secreted protein compositionsare produced .nNovember 2012 47