Prof. Dr. Thomas Höfer BioQuant and German ... - CellNetworks

CURRENTLY FUNDED PROJECTS
EU-FP7 large IP: ASSET: Assessing and striking sensitivities of embryonal tumors; SYBILLA:
Systems biology of T-cell activation in health and disease
BMBF systems biology consortium on: project: Dissecting the dynamics of epigenetic gene
silencing; project: Transcriptional control of T lymphocyte differentiation; project: A systems
approach to Candida infections
DFG-SFB 618, project: Integration of signal transduction and gene regulation of T cell
differentiation
Helmholtz Alliance on Systems Biology /SB Cancer
Currently supervising 8 doctoral theses, 2 MSc dissertations
PUBLICATIONS
Luijsterburg MS, von Bornstaedt G, Gourdin AM, Politi AZ, Moné MJ, Warmerdam DO,
Goedhart J, Vermeulen W, van Driel R and Höfer T, Stochastic and reversible assembly of a
multiprotein DNA repair complex ensures accurate target site recognition and efficient repair. J.
Cell Biol. 2010; 189: 445-463.
Salazar C, Brümmer A, Alberghina L and Höfer T, Timing control in regulatory networks by
multisite protein modifications. Trends Cell Biol. 2010; 20: 634-641.
Brümmer A, Salazar C, Zinzalla V, Alberghina L and Höfer T, Mathematical modeling of DNA
replication reveals a trade-off between coherence of origin activation and robustness against
rereplication. PLoS Comput. Biol.2010; 6:e1000783.
Mariani L, Schulz E, Lexberg M, Helmstetter C, Radbruch A, Löhning M and Höfer T, Shortterm
memory in gene induction reveals the regulatory principle behind stochastic interleukin-4
expression. Mol. Syst. Biol. 2010; 6:359.
Busse D, de la Rosa M, Hobiger K, Thurley K, Floßdorf M, Scheffold A and Höfer T, Competing
feedback loops shape IL-2 signaling between helper and regulatory T cells in cellular
microenvironments. Proc. Natl. Acad. Sci. USA 2010; 107: 3058–3063.
Nika K, Soldani S, Salek M, Gray A, Etzensperger R, Fugger L, Polzella P, Cerundolo V,
Dushek O, Höfer T, Viola A and Acuto O, Constitutive high levels of activated Lck drive T cell
antigen receptor signal transduction. Immunity 2010; 32: 766-777.
Schulz E, Mariani L, Radbruch A and Höfer T, Sequential polarization and imprinting of T-helper
type 1 differentiation by interferon-γ and interleukin-12. Immunity 2009; 30: 678-688.
Diernfellner ACR, Querfurth C, Salazar C, Höfer T and Brunner M, Phosphorylation modulates
rapid nucleo-cytoplasmic shuttling and cytoplasmic accumulation of Neurospora clock protein
FRQ on a circadian time scale. Genes Dev. 2009; 23: 2192-2200.
Salazar C, Politi A and Höfer T, Decoding of Ca2+ oscillations by phosphorylation cycles:
analytic results. Biophys. J. 2008; 94: 1203-1215.
Scheffold A, Murphy KM and Höfer T, Competition for cytokines: Treg cells take all. Nat.
Immunol. 2007; 8: 1285-1287.