EMBL-EBI Annual Scientific Report 2012

Rolf ApweilerPhD 1994, University of Heidelberg. At EMBLsince 1987. At EMBL-EBI since 1994.Joint Associate Director since 2012.Summary of progress 2012Sarah HunterInterProClaire O’DonovanUniProt contentMaria-Jesus MartinUniProt development• Issued five major releases of theInterPro database: created 1756new entries and integrated 2355signatures;• Released a new version ofInterProScan;• Redesigned and re-launched theInterPro website;• Incorporated a new InterProsearch facility based on thecentral EBI search engine.• Continued to manually annotateUniProtKB, with a particularfocus on the human and otherreference proteomes;• Collaborated closely withother resources worldwide toensure comprehensiveness,avoiding duplication of effort andachieving mutually beneficialexchange of data;• Substantially progressedautomatic annotation efforts,achieving a widening of thetaxonomic and annotation depthas well as establishing morecollaborations with externalinformatic- and laboratoryorientedgroups;• Increased manual and electronicGO annotation efforts: as ofNovember 2012 there were127 million GO annotations for18.9 million UniProtKB entries,covering more than 370 000taxonomic groups.• Analysed different interfacedesigns for accessing UniProtdata, focusing on user interactionwith the website;• Integrated new species asReference proteomes incollaboration with Ensembl andEnsembl Genomes to achieveconsensus sequence annotation;• Improved annotation tools(UniRule, Gene Ontology,proteome editors) to supportcuration of these resources;• In collaboration with Ensembl,RefSeq and PRIDE, extendedthe data-import infrastructureto incorporate variation andproteomics data;• Consolidated software andextended the databases toaccommodate a rapidly growingvolume of data.2012 EMBL-EBI Annual Scientific Report29