Genetics and Dietary Preferences - jifsan

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Chemesthesis/IrritationChemical skin senseStimuli: CO 2 , menthol, hot peppersPain, heat, cooling, tingle, itch etcReceptors: TRP ion channels - originallydiscovered as temperature sensitiveWhy do people like these in foods <strong>and</strong> beverages?
The Ion Channels of NociceptionNeuronalmembraneNTransient ReceptorPotential Channels(TRPs)CNCAcid SensingIon Channels(ASICs)Acid - TRPV1Heat - TRPV1, TRPV2Cold - TRPA1Capsaicin - TRPV1Mustard oil - TRPA1Membrane stretch - TRPV2Acid - DRASIC
Page 2 and 3:
Presenter disclaimer• The researc
Page 4 and 5:
Overview of Presentation:Why care a
Page 6 and 7: The SensesVisionHearingTouchSmellTa
Page 8 and 9: The Senses: Health ImpactVisionHear
Page 11 and 12: Diseases related to excess food int
Page 13 and 14: OdorPERCEPTIONareaOdorantsRetronasa
Page 15: SmellFunctions: Sex, food, warningN
Page 18 and 19: OdorantsOdor CodingOdor receptors:
Page 20 and 21: OdorantsOdor CodingOlfactoryepithel
Page 24 and 25: Wysocki & Beauchamp, PNAS, 1987
Page 26 and 27: Putative androstenone receptorOR7D4
Page 28: TasteDedicated to food choice: acce
Page 33: Major Discoveries in Taste Receptor
Page 37 and 38: Salt
Page 39: Too much?
Page 43 and 44: Recommendations in the past:1969: T
Page 45 and 46: Two potential strategies:Change the
Page 47 and 48: Epithelial Na channel (ENaC)
Page 49 and 50: Salt taste mechanisms• An ENaC is
Page 51 and 52: Decreasing Na intake is followed by
Page 53 and 54: Stepwise process for achieving fina
Page 55: Human adults do not compensateBeauc
Page 61: IbuprofenA widely used anti-inflamm
Page 65 and 66: Throat stinging compound(-)-decarbo
Page 67 and 68: Health-beneficial effects of the Me
Page 69 and 70: The Tongue’s Taste Cells are the
Page 71 and 72: ProspectsTargeting gut taste cellsN
Page 73 and 74: Flavor Receptors Elsewhere:Function
Page 75 and 76: Some Research Needs- What is the nu
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Genetics and Dietary Preferences - jifsan

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