Genetics and Dietary Preferences - jifsan

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Sperm and egg meet“Smell”Smell receptors: Spehr et al., Mol CellEndocrinol. 2006, 250.Taste receptors: Kiuchi et al., Cytogenet.Genome Res. 2006, 115.“Taste”
Some Research Needs- What is the nutritional importance of genetic variationin flavor receptors?- What nutritional roles are played by flavor receptorsoutside the nasal and oral cavities?- How does genetic variation interact withenvironmental variation to influence nutritionalphenotyes?- Are epigenetic modifications in flavor receptors ofnutritional significance?- How can our new and growing knowledge of flavorperception mechanisms and functions be translatedinto practical applications to reduce incidence andconsequence of human diseases?
Page 2 and 3:
Presenter disclaimer• The researc
Page 4 and 5:
Overview of Presentation:Why care a
Page 6 and 7:
The SensesVisionHearingTouchSmellTa
Page 8 and 9:
The Senses: Health ImpactVisionHear
Page 11 and 12:
Diseases related to excess food int
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OdorPERCEPTIONareaOdorantsRetronasa
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SmellFunctions: Sex, food, warningN
Page 18 and 19:
OdorantsOdor CodingOdor receptors:
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OdorantsOdor CodingOlfactoryepithel
Page 24 and 25: Wysocki & Beauchamp, PNAS, 1987
Page 26 and 27: Putative androstenone receptorOR7D4
Page 28: TasteDedicated to food choice: acce
Page 33: Major Discoveries in Taste Receptor
Page 37 and 38: Salt
Page 39: Too much?
Page 43 and 44: Recommendations in the past:1969: T
Page 45 and 46: Two potential strategies:Change the
Page 47 and 48: Epithelial Na channel (ENaC)
Page 49 and 50: Salt taste mechanisms• An ENaC is
Page 51 and 52: Decreasing Na intake is followed by
Page 53 and 54: Stepwise process for achieving fina
Page 55: Human adults do not compensateBeauc
Page 59 and 60: The Ion Channels of NociceptionNeur
Page 61: IbuprofenA widely used anti-inflamm
Page 65 and 66: Throat stinging compound(-)-decarbo
Page 67 and 68: Health-beneficial effects of the Me
Page 69 and 70: The Tongue’s Taste Cells are the
Page 71 and 72: ProspectsTargeting gut taste cellsN
Page 73: Flavor Receptors Elsewhere:Function
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Genetics and Dietary Preferences - jifsan

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