Inotropes and vasopressores - Cardiff PICU

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The search for a magic bulletFew R<strong>and</strong>omised studies◦ 3 Dengue Fever◦ 2 endotoxin antagonist (no effect)◦ APC no effect◦ Immunoglobulin 1989-91 (Saudi, Taiwan,Turkey India)◦ I small Polish Neonatal◦ 2 GM-CSF neonatal◦ HAS vs. saline Malaria
Page 2: Definition of ShockInadequate oxyge
Page 5 and 6: Physiology◦ Adult Oxygen demand 1
Page 7 and 8: Compensation◦ Increase cardiac ou
Page 9 and 10: Pathophysiology of Sepsis◦ Endoth
Page 12 and 13: A brief history of septic shock tre
Page 19 and 20: Efficacy variable Placebo N=235 ∗
Page 21 and 22: Fluid resuscitation
Page 23 and 24: Severe sepsis - Outcomes (9625 case
Page 25 and 26: RESULTS.34 patients (median age, 13
Page 27 and 28: CONCLUSIONRapid fluid resuscitation
Page 32 and 33: Figure 3. Type of fluid administere
Page 34 and 35: Inotropes and pressors◦ Advantage
Page 36 and 37: Available inotropes and pressors◦
Page 38 and 39: Catecholamine synthesis
Page 40 and 41: Dopamine◦ Precursor of noradrenal
Page 42 and 43: Noradrenaline◦ α1 and β1, with
Page 44 and 45: Phosphodiesterase inhibitors◦ Eno
Page 46: Vasopressin◦ Initially high endog
Page 49 and 50: Which inotropes when?
Page 51: Benefit from individualised resusci
Page 54: Shock should be clinically diagnose
Page 64:
A Comparison of ACCM-PALS Guideline
Page 68 and 69:
◦ Case control study of fatal vs.
Page 70 and 71:
Common errors (1)◦ Failure to est
Page 72 and 73:
Common errors (2)◦ Inadequate flu
Page 74 and 75:
Common errors (3)◦ KCl boluses◦
Page 76:
Summary◦ Volume◦ Inotropes◦ A
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Inotropes and vasopressores - Cardiff PICU

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