Inotropes and vasopressores - Cardiff PICU
Inotropes and vasopressores - Cardiff PICU
Inotropes and vasopressores - Cardiff PICU
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Dobutamine◦ Synthetic mixture of two stereo-isomers.◦ One isomer has β effects, the other α 1 .◦ 5 – 20 µg/kg/min β 1,2◦ Increases contractility◦ May ‘unmask’ hypovolaemia◦ SVR decreases. Direct coronaryvasodilatory effect.◦ >20 µg/kg/minα 1 dominates