Inotropes and vasopressores - Cardiff PICU

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Flow needs to be adequate forPerfusion pressureCritical point
Pathophysiology of Sepsis◦ Endothelial disease• Capillary leak◦ Hypovolaemia – hypovolaemic shock◦ ARDS – impaired oxygenation◦ Myocardial depression• IL-6 – cardiogenic shock◦ Abnormal vascular tone• High or low SVR – impaired organperfusion
Page 2: Definition of ShockInadequate oxyge
Page 5 and 6: Physiology◦ Adult Oxygen demand 1
Page 7: Compensation◦ Increase cardiac ou
Page 12 and 13: A brief history of septic shock tre
Page 15: The search for a magic bulletFew Ra
Page 20 and 21: esolve 28-day MortalityAdditional S
Page 22 and 23: Shock:GastroenteritisAbdo obstructi
Page 24 and 25: Role of early fluid resuscitation i
Page 26 and 27: RESULTS.34 patients (median age, 13
Page 28: 7000 critically ill adults
Page 33 and 34: Inotropes and pressors
Page 35 and 36: When to start inotropes◦ Sepsis -
Page 37 and 38: Choice of inotrope◦ Personal pref
Page 39 and 40: Receptor2 ndmessengerActionsα 1IP
Page 41 and 42: Adrenaline◦ α 1 , β 1 , β 2 .
Page 43 and 44: Dobutamine◦ Synthetic mixture of
Page 45 and 46: Phosphodiesterase inhibitors◦ Eno
Page 48 and 49: Vasopressin◦ Injection in humans
Page 50 and 51: Goal targeted treatment
Page 53 and 54: Largest mortality benefit of any se
Page 62:
Does it work?
Page 66:
Mortality associated with CV O 2sat
Page 69 and 70:
Pitfalls
Page 71 and 72:
Common errors (1)◦ Failure to est
Page 73 and 74:
Common errors (2)◦ Inadequate flu
Page 75 and 76:
Common errors (3)◦ KCl boluses◦
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Inotropes and vasopressores - Cardiff PICU

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