Inotropes and vasopressores - Cardiff PICU

Vasopressin◦ Injection in humans with normal BP – no effectunless very high doses used◦ Injection of physiological doses in hypovolaemia –vasoconstrcition◦ Enhances sensitivity to catecholamines◦ Coronary, Pulmonary and cerebral vasodilator atphysiological doses.◦ Clinical studies – 0.01 – 0.04U/min improve BPand responsiveness to catecholamines in septicand vasodilatory shock◦ Higher doses cause pulmonary, coronary andrenal vasoconstriction◦ RCT in adults shows improved CI, BP and fewerarrythmias if used with norad compared withnorad alone