Memoria CD.indd - ISHAM

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• Bernardino, S.Instituto de Ciências BiomédicasUniversidade de São Paulo, São Paulo, Brazile-mail: sibern@icb.usp.brNitric oxide but not TREG cells plays a major immunoregulatory role in a pulmonary model of fungalinfection• Costa, T.A.Instituto de Ciências BiomédicasUniversidade de São Paulo, Brazil.e-mail: tacosta@usp.brIL-10 deficiency determines a better fungicidal ability associated with overproduction of IFN-gamaand nitric oxide by Paracoccidioides brasiliensis infected macrophages• Silva, J.F.Faculdade de Ciências Farmacêuticas de Araraquara, UNESP, SP, Brazile-mail: silvajf@fcfar.unesp.Gp43 isoforms of Paracoccidioides brasiliensis as ligands of laminin, fibronectin and collagen type I.• Simoneide, S.S.Instituto de Ciências BiológicasUniversidade de Brasília, Brasília, DF, Brazile-mail: simoneide.silva@gmail.comComparative analysis of gene expression during macrophages infection by pathogenic fungi (Paracoccidioidesbrasiliensis and Histoplasma capsulatum).• Theodoro, R. C.Depto. de Microbiologia e ImunologiaIBB- Unesp, Botucatu, SP, Brazile-mail: raquel@ibb.unesp.brPhylogenetic analysis of PRP8 intein and mycological features in Paracoccidioides brasiliensisspecies complex.16
EditorialIn 1971 the Pan American Health Organization (PAHO) convened the First Pan American Symposiumon Paracoccidioidomycosis in Medellin, Colombia. It was in this city and country thatmany concepts -now classic- were revived and where many important advances in the areawere made. In 2008, 37 years later, we meet again in the same city and country to work on thesame subject, this time provided with new knowledge and renewed hopes for progress.In 1908 Adolfo Lutz, a physician trained in Switzerland and who held his medical practicein São Paulo, Brazil, described for the first time a peculiar disorder afflicting two patients andthat resembled a fungal disorder, coccidioidomycosis, described sixteen years earlier (1892)by Posadas in Argentina. Lutz examined tissue sections from Posadas’ original case and noticedthat the endogenous sporulation, characteristic of Coccidioides immitis, was absent fromhis own patients concluding that the Argentinian and the Brazilian mycoses were two differententities. Additionally, Lutz isolated the etiologic agent in its mycelial form and without naming itwrote in his report that “… the tissue forms are different from the ones observed in cultures…”.Thus, Lutz’ keen mind allowed him to discover a new disease, a new agent and its dimorphicproperties, all in a matter of a few months. From the very beginning, Lutz had set an examplefor all the researchers who were to follow, including most of us.One hundred years have elapsed by since Lutz’ discovery, and this century has providedthose of us, interested in paracoccidioidomycosis and Paracoccidioides brasiliensis, a wealthof findings but most importantly, a multitude of doors open to future research, and a richness ofquestions still unsolved. After all, it is the question that matters.Nowadays the fungus has become an important research tool due to its versatility and enduranceand, why not, its capricious moods. Yet patients continue to experiment the “slings andarrows” inflicted by the fungus and suffer its ill effects when their vital organs are attacked.Judging by the abstracts that will be presented during this X International Congress on Paracoccidioidomycosis,a great deal of progress has been accomplished in all fields of knowledgeon this and related mycoses. It appears that several of the previously existing “icebergs” arenow conquerable with thorough research. It remains to be determined whether or not such freshknowledge will solve some of the most significant problems still standing. Be as it may, we willadvance further only if we join efforts in searching common goals.17
Page 1 and 2: ISSN 0120-4157BiomédicaRevista del
Page 3 and 4: Biomédica Instituto Nacional de Sa
Page 5: Proceedings of theX International C
Page 8 and 9: Financial CommiteeLavive Rebaje de
Page 10 and 11: • Henrique L. Lenzi. Departamento
Page 12 and 13: United States of America• Beatriz
Page 15: Scholarship WinnersTraveling Award
Page 19 and 20: Scientific Program15:00-18:00 Arriv
Page 21 and 22: Symposium 3. Virulence factors and
Page 23 and 24: 16:20-16:4016:40-17:0017:00-17:2017
Page 25 and 26: 14:20-14:4014:40-15:0015:00-15:2015
Page 27 and 28: Symposia IndexPage434344Symposium 1
Page 29 and 30: 91CDC42p controls yeast-cell shape
Page 31 and 32: Poster Index1 Clinical Aspects / Ca
Page 33 and 34: 2-02p 1552-03p 1562-04p 1562-05p 15
Page 35 and 36: 4-20p 1744-21p 1754-22p 1754-23p 17
Page 37 and 38: 5-10p 1915-11p 1925-12p 1925-13p 19
Page 39 and 40: 6-06p 2076-07p 2086-08p 2086-09p 20
Page 41: Symposium1P. brasiliensis:Genomics
Page 44 and 45: Post-genomic contribution to the kn
Page 46 and 47: quence. The first domain (aa 1-1073
Page 49 and 50: Experimental animal models and thei
Page 51 and 52: CD4 + CD25 + FoxP3 + T cells were d
Page 53 and 54: Pattern recognition receptors in th
Page 55: A strategy for the generation of a
Page 59 and 60: Histoplasma virulence mechanisms wi
Page 61 and 62: Virulence insights from the P. bras
Page 63: certain antifungal drugs. The effec
Page 67 and 68:
Microbicidal mechanisms exerted by
Page 69 and 70:
depletion induces a more severe and
Page 71 and 72:
did not restore the lymphoprolifera
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Historical accountsCoccidioidomycos
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In South America, from Venezuela to
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B-1 cells modulate the kinetics of
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mechanisms can lead to permissivene
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of mice (PBS-untreated as negative
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Symposium6Fungal cellular biology A
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wall construction, mating and osmo-
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heat shock proteins, processes of h
Page 92 and 93:
Differential analysis of extracellu
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The evolving public health importan
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Several difficulties have been iden
Page 101 and 102:
The impact of histoplasmosis in HIV
Page 103 and 104:
The conjunct data from 66 cases pre
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Although drug serum levels are an o
Page 107 and 108:
Historical accountsHistoplasmosisHi
Page 109:
Histoplasmosis in the United States
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The value and the promise of molecu
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need to consider the P. brasiliensi
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Lymphomononuclear cells of 29 patie
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Symposium10Advances on antifungal A
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and Cryptococcus neoformans. MICs f
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sue assay, revelead that P10-PLGA c
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P. brasiliensis growth and infectiv
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Influence of alternating coffee and
Page 131 and 132:
in Arábica and 0.9% Robusta variet
Page 133:
Symposium12Evolutive Biology of P.
Page 136 and 137:
Is Paracoccidioides brasiliensis an
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matter of conjecture. As a global i
Page 141 and 142:
1-01Clinical epidemiology of paraco
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1-05Epidemiological and clinical fe
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1-09Acute severe paracoccidioidomyc
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1-13Nested-PCR, immunoblotting and
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1-17Scintigraphic evaluation of ent
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1-21Paracoccidioidomycosis in a ren
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Poster Session2Diagnosis
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2-03Combined use of Paracoccidioide
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Poster Session3Epidemiology / Ecolo
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3-03Spatial distribution of chronic
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4-01Towards a molecular genetic sys
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4-05Evidence for positive selection
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4-09Formamidase of Paracoccidioides
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4-13Mating type genes MAT1-1 and MA
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4-17Autophagy in the human pathogen
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4-21Transcription regulation of the
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4-25Changes in the transcription le
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4-29The high affinity copper transp
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4-33Analysis and identification of
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4-37The heath shock factor of Parac
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5-01Phenotypic and functional chara
Page 189 and 190:
5-05Polymorphisms analysis of CTLA-
Page 191 and 192:
5-09Alterations in pulmonary mechan
Page 193 and 194:
5-13The influence of ß2 integrin i
Page 195 and 196:
5-17Prostaglandin inhibits Paracocc
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5-21IL-10 deficiency determines a b
Page 199 and 200:
5-25Granulomatous imflammation and
Page 201:
5-29Modulation of experimental para
Page 205 and 206:
6-01Timing of itraconazole therapy
Page 207 and 208:
6-05Amphotericin B-PLGA-DMSA nanopa
Page 209 and 210:
6-09Antagonistic effect of farnesol
Page 211 and 212:
6-13Therapeutic DNA vaccine in BALB
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Poster Session7Other Mycoses
Page 216 and 217:
7-03Study of genotypic and phenotyp
Page 218 and 219:
7-07Detection of DNA in peripheral
Page 220 and 221:
Catão E. 193Cavalcante RS. 103, 14
Page 222 and 223:
Molano VM. 143Molina RFS. 199Montoy
Page 224 and 225:
Trinca LA. 167Tristão FSM. 71Urán
Page 226 and 227:
Personal ContributorsDrs. Karl V. a
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