A Randomized Trial of Thymoglobulin to Prevent Chronic ... - CBMTG

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A Randomized Trial of Thymoglobulinto Prevent Chronic Graft versus Host Diseasein Patients Undergoing Hematopoietic Progenitor CellTransplantation (HPCT) from Unrelated Donors.Study CBMTG-0801Study CBMTG-0801
Administration0801 Trial Committee• Stephen Couban• Ronan Foley• Stephanie Lee• Tony Panzarella• Jean Roy• Kirk Schultz• David Schweitzer• Christopher Skedgel• Cynthia Toze• Holly Kerr• Irwin WalkerCollaboration• Paul MartinCoordinationUniversity of British Columbia• Clay Smith• Holly KerrData Safety MonitoringCommittee (DSMC)• Pediatric BMT Consortium
Page 1 and 2: A Randomized Trial of Thymoglobulin
Page 3 and 4: Appendix AIllustrations of cGVHD -
Page 5: Quality of LifeFraser CJ et al. Imp
Page 14 and 15: FundingTOTAL GRANT:CIHR:$1,245,055
Page 16 and 17: FinkeLancet Oncol 2009;10: 855-64Ba
Page 18 and 19: Time to Onset of Prednisone RxMielk
Page 20 and 21: Secondary End-Points• Time to eng
Page 22 and 23: Treatment Plan - ThymoglobulinThe e
Page 24 and 25: Flu-Bu-ATG (Slavin) vs F-TBI (Seatt
Page 26 and 27: Benefits and Harms• BENEFITS• L
Page 28 and 29: PTLD in Unrelated/Mismatch +ATGStud
Page 30 and 31: Performance of QPCR test for EBVAss
Page 32 and 33: cGVHD Manifestions - NIHFilipovich
Page 34 and 35: cGVHD Case Report Form (CRF)
Page 36 and 37: cGVHD Case Report Form (CRF)
Page 38 and 39: Body Surface Area (Rule of 9)
Page 40 and 41: Will CBMTG 0801 succeed?In part for
Page 42 and 43: Flowers ME, Storer BE, Lee SJ, et a
Page 44: Thank you

A Randomized Trial of Thymoglobulin to Prevent Chronic ... - CBMTG

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