A Randomized Trial of Thymoglobulin to Prevent Chronic ... - CBMTG

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Treatment Plan - ThymoglobulinThe experimental intervention is the addition of Thymoglobulinto the standard preparative regimen.The total dose of Thymoglobulin is 4.5 mg/kg (actual bodyweight, not effective body weight), given in divided doses asfollows:Day -2: 0.5 mg/kgDay -1: 2.0 mg/kgDay 0: 2.0 mg/kgDayDayDayDayDayDayDayDay–7–6–5–4–3–2–10 ¤Preparative Regimen(Arms A and B)Myeloablative or non-myeloablative (syn.RIC*)conditioning regimen†GraftInfusionThymoglobulin0.52.02.0(Arm B only)mg/kgmg/kgmg/kg
Treatment Plan – PreparativeRegimensMYELOABLATIVE• CY-TBI• BUCY• BUFLUNON-MYELOABLATIVE (syn. RIC)• BUFLU(ATG) - Slavin• FLU-TBI - Seattle• FLU-MELRegimens containing ATG or Campath not allowed
Page 1 and 2: A Randomized Trial of Thymoglobulin
Page 3 and 4: Appendix AIllustrations of cGVHD -
Page 5: Quality of LifeFraser CJ et al. Imp
Page 12 and 13: A Randomized Trial of Thymoglobulin
Page 14 and 15: FundingTOTAL GRANT:CIHR:$1,245,055
Page 16 and 17: FinkeLancet Oncol 2009;10: 855-64Ba
Page 18 and 19: Time to Onset of Prednisone RxMielk
Page 20 and 21: Secondary End-Points• Time to eng
Page 24 and 25: Flu-Bu-ATG (Slavin) vs F-TBI (Seatt
Page 26 and 27: Benefits and Harms• BENEFITS• L
Page 28 and 29: PTLD in Unrelated/Mismatch +ATGStud
Page 30 and 31: Performance of QPCR test for EBVAss
Page 32 and 33: cGVHD Manifestions - NIHFilipovich
Page 34 and 35: cGVHD Case Report Form (CRF)
Page 36 and 37: cGVHD Case Report Form (CRF)
Page 38 and 39: Body Surface Area (Rule of 9)
Page 40 and 41: Will CBMTG 0801 succeed?In part for
Page 42 and 43: Flowers ME, Storer BE, Lee SJ, et a
Page 44: Thank you

A Randomized Trial of Thymoglobulin to Prevent Chronic ... - CBMTG

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