A Randomized Trial of Thymoglobulin to Prevent Chronic ... - CBMTG
A Randomized Trial of Thymoglobulin to Prevent Chronic ... - CBMTG
A Randomized Trial of Thymoglobulin to Prevent Chronic ... - CBMTG
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Epstein Barr Virus (EBV)BACKGROUND1. Herpes virus type 4.2. Infects over 90% <strong>of</strong> worlds population, mostly unrecognized, or as IM.3. Latency, like other herpesviruses (HSV, HZV, CMV)4. Latent state in B-lymphocytes5. Highly immunogenic resulting in B-cell proliferation, occasionally malignant.6. Activation controlled by EBV-specific T-cells7. Activation can result in a spectrum <strong>of</strong> disorders collectively termed PostTransplant Lymphoproliferative Disorder (PTLD).8. Median time <strong>to</strong> document EBV activation by QPCR following HPCT is 60days (most
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