Post Transcriptional Gene Silencing in Plants (PTGS) - Eurasnet.info
Post Transcriptional Gene Silencing in Plants (PTGS) - Eurasnet.info
Post Transcriptional Gene Silencing in Plants (PTGS) - Eurasnet.info
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POST - TRANSCRIPTIONALGENE SILENCING -<strong>PTGS</strong>„RNA <strong>in</strong>terference“ RNAi, a phenomenon <strong>in</strong> C. elegansand Drosophila for silenc<strong>in</strong>g of gene expression through asignal <strong>in</strong>duced by double stranded RNA (dsRNA)C. elegans: <strong>in</strong>jection of dsRNA: correspond<strong>in</strong>g gene productdisapears <strong>in</strong> the somatic cells, also <strong>in</strong> F1 generation.However, F2 normal phenotyp, no mutation, no sequencedifference: is post-transcriptional because only exonsequences show RNAi. In polycistronic pre-mRNAs only thesequences of the <strong>in</strong>itial dsRNA are silenced. RNAdegradation is at the level of nucleus and cytoplasm.WHAT HAPPENS? WHY is DEGRADATIONtransmissible through the whole organism??
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