RNA Splicing: Removal of Introns from Primary ... - EURASNET
RNA Splicing: Removal of Introns from Primary ... - EURASNET
RNA Splicing: Removal of Introns from Primary ... - EURASNET
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Spliceosome - assembly <strong>of</strong> the splicing apparatus• splicing sn<strong>RNA</strong>s - U1, U2, U4, U5, U6• sn<strong>RNA</strong>s are associated with proteins (snRNPs or “snurps”)• antibodies to snRNPs are seen in the autoimmunedisease systemic lupus erythematosus (SLE)= hnRNP proteinsintron 1U22’OH-ASpliceosome assemblyStep 1: binding <strong>of</strong> U1and U2 snRNPsexon 1 exon 2U15’ G-p-G-U -A-G-p-G3’
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