ATSDR Draft Toxicological Profile for Radon_September 2008.pdf

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RADONiiDISCLAIMERThe use of company or product name(s) is for identification only and does not imply endorsement by theAgency for Toxic Substances and Disease Registry.This information is distributed solely for the purpose of pre dissemination public comment underapplicable information quality guidelines. It has not been formally disseminated by the Agency for ToxicSubstances and Disease Registry. It does not represent and should not be construed to represent anyagency determination or policy.***DRAFT FOR PUBLIC COMMENT***
RADONiiiUPDATE STATEMENTA Toxicological Profile for Radon was released in 1990. This edition supersedes any previously releaseddraft or final profile.Toxicological profiles are revised and republished as necessary. For information regarding the updatestatus of previously released profiles, contact ATSDR at:Agency for Toxic Substances and Disease RegistryDivision of Toxicology and Environmental Medicine/Applied Toxicology Branch1600 Clifton Road NEMailstop F-32Atlanta, Georgia 30333***DRAFT FOR PUBLIC COMMENT***
Page 1: DRAFTTOXICOLOGICAL PROFILE FORRADON
Page 5 and 6: RADONvFOREWORD This toxicological p
Page 7 and 8: RADONviiQUICK REFERENCE FOR HEALTH
Page 9 and 10: RADONixThe American College of Occu
Page 11 and 12: RADONxiCONTRIBUTORSCHEMICAL MANAGER
Page 13 and 14: RADONxiiiPEER REVIEWA peer review p
Page 15 and 16: RADONxvCONTENTSDISCLAIMER .........
Page 17 and 18: RADONxvii5. PRODUCTION, IMPORT/EXPO
Page 19 and 20: RADONxixLIST OF FIGURES3-1. Concept
Page 21 and 22: RADONxxiLIST OF TABLES3-1. Selected
Page 23 and 24: RADON11. PUBLIC HEALTH STATEMENTThi
Page 25 and 26: RADON 31. PUBLIC HEALTH STATEMENT1.
Page 27 and 28: RADON 51. PUBLIC HEALTH STATEMENT1.
Page 29 and 30: RADON71. PUBLIC HEALTH STATEMENTAdd
Page 31 and 32: RADON92. RELEVANCE TO PUBLIC HEALTH
Page 33 and 34: RADON 112. RELEVANCE TO PUBLIC HEAL
Page 35 and 36: RADON 133. HEALTH EFFECTS3.1 INTROD
Page 37 and 38: RADON 153. HEALTH EFFECTSin 1 L of
Page 39 and 40: RADON 173. HEALTH EFFECTSselected d
Page 41 and 42: RADON 193. HEALTH EFFECTStoxicologi
Page 43 and 44: RADON 213. HEALTH EFFECTSTable 3-2.
Page 45 and 46: RADON 233. HEALTH EFFECTSTable 3-3.
Page 47 and 48: RADON 253. HEALTH EFFECTSvalue is s
Page 49 and 50: RADON 273. HEALTH EFFECTSassessment
Page 51 and 52: RADON 293. HEALTH EFFECTSsome cohor
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RADON 313. HEALTH EFFECTSAssessment
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RADON 333. HEALTH EFFECTS3.2.3 Derm
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RADON 353. HEALTH EFFECTSTable 3-6.
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RADON 373. HEALTH EFFECTSof water (
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RADON 393. HEALTH EFFECTSof the tox
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RADON 413. HEALTH EFFECTSand Strong
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RADON 433. HEALTH EFFECTSKinetics o
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RADON 453. HEALTH EFFECTSinitiating
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RADON 473. HEALTH EFFECTSDisease Re
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RADON 493. HEALTH EFFECTSpharmacody
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RADON 513. HEALTH EFFECTSFigure 3-1
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RADON 533. HEALTH EFFECTSHuman Resp
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RADON 613. HEALTH EFFECTSaction of
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RADON 633. HEALTH EFFECTS• For Ty
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RADON 653. HEALTH EFFECTSinterstiti
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RADON 673. HEALTH EFFECTSin the sto
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RADON 713. HEALTH EFFECTScoefficien
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RADON 733. HEALTH EFFECTSinformatio
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RADON 753. HEALTH EFFECTSdamage can
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RADON 773. HEALTH EFFECTSeliminatio
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RADON 793. HEALTH EFFECTSA biomarke
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RADON 813. HEALTH EFFECTSAssociatio
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RADON 833. HEALTH EFFECTSand/or die
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RADON 853. HEALTH EFFECTS3.12 ADEQU
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RADON 873. HEALTH EFFECTSintermedia
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RADON 893. HEALTH EFFECTSdata do no
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RADON 913. HEALTH EFFECTShigher reg
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RADON 934. CHEMICAL, PHYSICAL, AND
Page 117 and 118:
RADON 954. CHEMICAL AND PHYSICAL IN
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Page 121 and 122:
Page 123 and 124:
RADON 1015. PRODUCTION, IMPORT/EXPO
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RADON 1035. PRODUCTION, IMPORT/EXPO
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RADON 1056. POTENTIAL FOR HUMAN EXP
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RADON 1317. ANALYTICAL METHODSThe p
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RADON 1337. ANALYTICAL METHODSwhich
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RADON 1357. ANALYTICAL METHODSsimil
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RADON 1377. ANALYTICAL METHODSusing
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RADON 1397. ANALYTICAL METHODSTable
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RADON 1418. REGULATIONS, ADVISORIES
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Page 167 and 168:
Page 169 and 170:
RADON 1479. REFERENCES*ACGIH. 2007.
Page 171 and 172:
RADON 1499. REFERENCESAmandus H, Co
Page 173 and 174:
RADON 1519. REFERENCESAxelson O. 19
Page 175 and 176:
RADON 1539. REFERENCES*Berger GS, e
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RADON 1559. REFERENCES*Brooks AL, R
Page 179 and 180:
RADON 1579. REFERENCES*ChemIDplus.
Page 181 and 182:
RADON 1599. REFERENCESCohen BL, Nel
Page 183 and 184:
RADON 1619. REFERENCES*Cross FT, Pa
Page 185 and 186:
RADON 1639. REFERENCESDuport P. 200
Page 187 and 188:
RADON 1659. REFERENCES*EPA. 1997. S
Page 189 and 190:
RADON 1679. REFERENCES*Evans HH, Me
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RADON 1699. REFERENCES*Fomon SJ. 19
Page 193 and 194:
RADON 1719. REFERENCESGustavsson P,
Page 195 and 196:
RADON 1739. REFERENCESHofmann W, Cr
Page 197 and 198:
RADON 1759. REFERENCES*ICRP. 1978.
Page 199 and 200:
RADON 1779. REFERENCES*Jonassen N.
Page 201 and 202:
RADON 1799. REFERENCES*Krewski D, L
Page 203 and 204:
RADON 1819. REFERENCESLeenhouts HP.
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RADON 1839. REFERENCESLubin JH. 199
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RADON 1859. REFERENCESMasse R, Cham
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RADON 1879. REFERENCESMoolgavkar SH
Page 211 and 212:
RADON 1899. REFERENCES*Nazaroff W,
Page 213 and 214:
RADON 1919. REFERENCES*NRC. 1991. C
Page 215 and 216:
RADON 1939. REFERENCESPlacek V, Sev
Page 217 and 218:
RADON 1959. REFERENCESRehman FU, Ja
Page 219 and 220:
RADON 1979. REFERENCES*Sandler DP,
Page 221 and 222:
RADON 1999. REFERENCESSolomon SB, O
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RADON 2019. REFERENCESSzőke I, Bal
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RADON 2039. REFERENCES*UNSCEAR. 200
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RADON 2059. REFERENCES*Wang RY, Chi
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RADON 2079. REFERENCESeds. Oxygen r
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RADON 20910. GLOSSARYSome terms in
Page 233 and 234:
RADON 21110. GLOSSARYAttenuation—
Page 235 and 236:
RADON 21310. GLOSSARYCharged Partic
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RADON 21510. GLOSSARYDisintegration
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RADON 21710. GLOSSARYElectron—A s
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RADON 21910. GLOSSARYHalf-life, Rad
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RADON 22110. GLOSSARYLethal Concent
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RADON 22310. GLOSSARYOdds Ratio (OR
Page 247 and 248:
RADON 22510. GLOSSARYRadiation—Th
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RADON 22710. GLOSSARYReproductive T
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RADON 22910. GLOSSARYTissue Weighti
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RADON A-1APPENDIX A. ATSDR MINIMAL
Page 255 and 256:
RADON B-1Chapter 1Public Health Sta
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RADON B-3APPENDIX BLEGENDSee Sample
Page 259 and 260:
RADON B-5APPENDIX B(18) Estimated U
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RADON B-7APPENDIX B***DRAFT FOR PUB
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RADON C-1APPENDIX C. ACRONYMS, ABBR
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RADON C-3APPENDIX CMCLMCLGMFMFOmgmL
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RADON C-5APPENDIX C> greater than
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RADON D-1APPENDIX D. OVERVIEW OF BA
Page 271 and 272:
RADON D-3APPENDIX D-0.693t/TradA =
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RADON D-5APPENDIX DMass, charge, an
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RADON D-7APPENDIX Dcorresponds to e
Page 277 and 278:
RADON D-9APPENDIX Dprogress to fibr
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RADOND-11APPENDIX DTable D-4. Weigh
Page 281 and 282:
RADON D-13APPENDIX DICRP. 1984. Int
Page 283 and 284:
RADON E-1APPENDIX E. INDEXabsorbed
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