ATSDR Draft Toxicological Profile for Radon_September 2008.pdf

RADON 683. HEALTH EFFECTSTable 3-9. Parameters in the NAS (1999b) PBPK Model aFlow (percent Tissue mass Tissue:bloodCompartment cardiac output) (kg) Tissue density partition coefficientStomach wall 1.0 0.15 1.05 0.7Small intestine wall 10.0 0.64 1.04 0.7Upper largeintestine wall2.0 0.21 1.04 0.7Lower largeintestine wall2.0 0.16 1.04 0.7Pancreas 1.0 0.10 1.05 0.4Spleen 3.0 0.18 1.05 0.7Adrenals 0.3 0.014 1.02 0.7Brain 12.0 1.4 1.03 0.7Heart wall 4.0 0.33 1.03 0.5Liver 6.5 1.8 1.04 0.7Lung tissue 2.5 0.47 1.05 0.7Kidneys 19.0 0.31 1.05 0.66Muscle 17.0 28.0 1.04 0.36Red marrow 3.0 1.5 1.03 8.2Yellow marrow 3.0 1.5 0.98 8.2Trabecular bone 0.9 1.0 1.92 0.36Cortical bone 0.6 4.0 1.99 0.36Adipose tissue 5.0 12.5 0.92 11.2Skin 5.0 2.6 1.05 0.36Thyroid 1.5 0.02 1.05 0.7Testes 0.05 0.035 1.04 0.43Other 3.2 3.2 1.04 0.7a Values shown for physiological parameters (flows, masses, densities) are for adults.Source: NAS 1999b***DRAFT FOR PUBLIC COMMENT***