Guideline on Treatment of Patients with Severe and Multiple ... - AWMF
Guideline on Treatment of Patients with Severe and Multiple ... - AWMF
Guideline on Treatment of Patients with Severe and Multiple ... - AWMF
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S3 <str<strong>on</strong>g>Guideline</str<strong>on</strong>g> <strong>on</strong> <strong>Treatment</strong> <strong>of</strong> <strong>Patients</strong> <strong>with</strong> <strong>Severe</strong> <strong>and</strong> <strong>Multiple</strong> Injuries<br />
B Methods<br />
The guideline project was first announced in December 2004 <strong>and</strong> again in May 2009.<br />
The guideline <strong>on</strong> the “<strong>Treatment</strong> <strong>of</strong> multiply injured patients <strong>and</strong> those <strong>with</strong> severe injuries” was<br />
developed according to a binding process <strong>with</strong> a structured plan. It is the result <strong>of</strong> a systematic<br />
literature search <strong>and</strong> critical evaluati<strong>on</strong> <strong>of</strong> the evidence from available data using scientific<br />
methods as well as discussi<strong>on</strong> <strong>with</strong> experts in a formal c<strong>on</strong>sensus procedure.<br />
B.1 Literature search <strong>and</strong> selecti<strong>on</strong> <strong>of</strong> evidence<br />
The key questi<strong>on</strong>s for the systematic literature search <strong>and</strong> evaluati<strong>on</strong> were formulated <strong>on</strong> the<br />
basis <strong>of</strong> preliminary work during 2005. The literature searches were carried out in the MEDLINE<br />
database (via PubMed) using medical keywords (Medical Subject Headings/MeSH), partly<br />
supplemented by a free text search. The filter recommended in PubMed was used to identify<br />
systematic reviews. Supplementary searches were c<strong>on</strong>ducted in the Cochrane Library<br />
(CENTRAL) (in this case <strong>with</strong> keywords <strong>and</strong> text words in the title <strong>and</strong> abstract). The<br />
publicati<strong>on</strong> period selected was 1995-2010, <strong>and</strong> German <strong>and</strong> English as the publicati<strong>on</strong><br />
languages.<br />
The literature searches were carried out partly by the Institute for Research in Operative<br />
Medicine (IFOM) <strong>and</strong> partly by the authors themselves. The results <strong>of</strong> the literature searches,<br />
sorted according to topic, were forwarded to the individual authors resp<strong>on</strong>sible for each topic.<br />
The underlying key questi<strong>on</strong>s, the literature searches carried out <strong>with</strong> date <strong>and</strong> number <strong>of</strong> hits<br />
<strong>and</strong>, if applicable, search limitati<strong>on</strong>s were documented <strong>and</strong> can be found in the appendix to the<br />
separate Methods Report.<br />
Selecti<strong>on</strong> <strong>and</strong> evaluati<strong>on</strong> <strong>of</strong> the relevant literature<br />
The authors <strong>of</strong> each chapter selected <strong>and</strong> evaluated the literature included in the guideline. This<br />
was carried out according to the criteria <strong>of</strong> evidence-based medicine. Sufficient r<strong>and</strong>omizati<strong>on</strong>,<br />
allocati<strong>on</strong> c<strong>on</strong>cealment, blinding <strong>and</strong> the statistical analysis were taken into account.<br />
The evidence statement for the recommendati<strong>on</strong>s was based <strong>on</strong> the evidence classificati<strong>on</strong> <strong>of</strong> the<br />
Oxford Center <strong>of</strong> Evidence-Based Medicine (CEBM), March 2009 versi<strong>on</strong>. In formulating the<br />
recommendati<strong>on</strong>s, priority was given to studies <strong>with</strong> the highest level <strong>of</strong> evidence available<br />
(LoE).<br />
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