and Incomplete Septal Cirrhosis
Non-cirrhotic portal hypertension & incomplete septal cirrhosis
Non-cirrhotic portal hypertension & incomplete septal cirrhosis
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Non-Cirrhotic Intrahepatic Portal Hypertension - Clinical Aspects<br />
• Many cases probably asymptomatic<br />
– Only 1/64 cases diagnosed with NRH at autopsy were diagnosed prior to death<br />
(Wanless 1990)<br />
• Most cases have portal hypertension with preserved synthetic function<br />
– Prognosis better than cirrhotic patients with a similar severity of portal<br />
hypertension ( Merkel 1992)<br />
• Cholestatic LFTs common<br />
• Raised Alk Phos in 25 % of cases of NRH reviewed by Reshamala (2006)<br />
• Abnormal LFTs (mainly cholestatic) presenting feature in 76% NRH cases<br />
reported by Morris (2010). Only 9.5% had portal hypertension as presenting<br />
feature<br />
• Alk Phos levels higher in patients with symptomatic portal hypertensive biliopathy<br />
(Dhiman 2007)
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