Cell Nucleus

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Glucocorticoid receptor: example of a specific transcription factor. Structure DNA binding domain, recognizes specific DNA sequence Since it is a dimer it recognizes a palindromic sequence Activation domain, alters transcription, usually through a corepressor or co-activator 5’ nnnnnnnnnnnnAGAACAnnnTGTTCTnnnnnn3’ 3’ nnnnnnnnnnnnTCTTGTnnnACAAGAnnnnnn5’ Function: how does it turn on the gene? Brings in Co-activators which: A. Supply general transcription factors for RNA polymerase II, TAFs B. Alter chromatin structure 12 Thursday, January 21, 2010
Response Elements on the PEPCK Gene PPARγ/RXR HNF-3 Insulin GR RAR T 3 C/EBP Receptor HNF-1 Fos/Jun NF1 CREB/ CREM Fos/Jun DBP C/EBP TBP PolII PPARRE AF1 GRE IRE TRE P4 P3I P3II P2 P1 TATA CRE-1 PEPCK regulates glucose metabolism Regulated by many different hormones A site of integration Thursday, January 21, 2010 13
Page 1 and 2: Cell Nucleus Gene Structure Control
Page 3 and 4: - Entire genome in each cell. How d
Page 5 and 6: Transcriptional Control RNA polyme
Page 7 and 8: Components of the Promoter B. Proxi
Page 9 and 10: Components of the Promoter D) Enhan
Page 11: The Glucocorticoid Receptor Glucoco
Page 15 and 16: Question: How do transcription fact
Page 17 and 18: More on Coactivators Coactivators
Page 19 and 20: Histone Acetyltransferase: Step I C
Page 21 and 22: Transcriptional Repression: Histone
Page 23 and 24: DNA Methyltransferases Add methyl
Page 25 and 26: Methylated sites promote gene inact
Page 27 and 28: Main levels of gene expression 1. G

Cell Nucleus

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