Cell Nucleus

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Control of Gene Expression in Eukaryotes Transcription level if and how often a gene is transcribed. Processing level different messenger RNAs made from a given gene (alternative splicing) Translational level How much of the mRNA is made into protein.(and mRNA lifetime) Post-translation Protein lifetime 4 Thursday, January 21, 2010
Transcriptional Control RNA polymerase II transcribes some genes much more frequently than others This depends on regulatory sites on the DNA and the presence of transcription factors. hnRNA “factors” Thursday, January 21, 2010 5’ Regulatory sites RNA pol II gene 3’ 5
Page 1 and 2: Cell Nucleus Gene Structure Control
Page 3: - Entire genome in each cell. How d
Page 7 and 8: Components of the Promoter B. Proxi
Page 9 and 10: Components of the Promoter D) Enhan
Page 11 and 12: The Glucocorticoid Receptor Glucoco
Page 13 and 14: Response Elements on the PEPCK Gene
Page 15 and 16: Question: How do transcription fact
Page 17 and 18: More on Coactivators Coactivators
Page 19 and 20: Histone Acetyltransferase: Step I C
Page 21 and 22: Transcriptional Repression: Histone
Page 23 and 24: DNA Methyltransferases Add methyl
Page 25 and 26: Methylated sites promote gene inact
Page 27 and 28: Main levels of gene expression 1. G

Cell Nucleus

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