Cell Nucleus

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methylated “GC island” RNA polymerase stops H1 MeCP2 TATA Sin3 H1 H1 de-acetylates MeCP2 “recruitment” Inactivation of DNA regions by MeCP2/Sin3 25 Thursday, January 21, 2010
Main levels of gene expression 1. Genome. (nucleus) Makes gene available for expression 1. Chromosome de-condensation 2. DNA methylation 3. Histone acetylation 4. Changes in HMG proteins, nuclear matrix 2. Transcription. Makes primary RNA transcript hnRNA 1. Control by transcription factors 3. RNA processing, and nuclear export 1. RNA splicing, other processing events 2. Movement into the cytoplasm, where translation happens 4. Translation (cytoplasm) 1. mRNA degradation and turnover 2. Translation control by initiation factors, repressors, microRNAs 5. Post-translation 1. Protein folding 2. Polypeptide cleavage 3. Modifications 4. Destination to correct location in the cell, or for secretion Resulting Functional protein. further regulation by degradation, turnover, phosphorylation etc. 26 Thursday, January 21, 2010
Page 1 and 2: Cell Nucleus Gene Structure Control
Page 3 and 4: - Entire genome in each cell. How d
Page 5 and 6: Transcriptional Control RNA polyme
Page 7 and 8: Components of the Promoter B. Proxi
Page 9 and 10: Components of the Promoter D) Enhan
Page 11 and 12: The Glucocorticoid Receptor Glucoco
Page 13 and 14: Response Elements on the PEPCK Gene
Page 15 and 16: Question: How do transcription fact
Page 17 and 18: More on Coactivators Coactivators
Page 19 and 20: Histone Acetyltransferase: Step I C
Page 21 and 22: Transcriptional Repression: Histone
Page 23 and 24: DNA Methyltransferases Add methyl
Page 25: Methylated sites promote gene inact

Cell Nucleus

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