Cell Nucleus
Genetic lecture 3
Genetic lecture 3
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Main levels of gene<br />
expression<br />
1. Genome. (nucleus) Makes gene available for expression<br />
1. Chromosome de-condensation<br />
2. DNA methylation<br />
3. Histone acetylation<br />
4. Changes in HMG proteins, nuclear matrix<br />
2. Transcription. Makes primary RNA transcript hnRNA<br />
1. Control by transcription factors<br />
3. RNA processing, and nuclear export<br />
1. RNA splicing, other processing events<br />
2. Movement into the cytoplasm, where translation happens<br />
4. Translation (cytoplasm)<br />
1. mRNA degradation and turnover<br />
2. Translation control by initiation factors, repressors, microRNAs<br />
5. Post-translation<br />
1. Protein folding<br />
2. Polypeptide cleavage<br />
3. Modifications<br />
4. Destination to correct location in the cell, or for secretion<br />
Resulting Functional protein.<br />
further regulation by degradation, turnover, phosphorylation etc.<br />
26<br />
Thursday, January 21, 2010
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