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An Introduction to the Endocrine System

An Introduction to the Endocrine System

An Introduction to the Endocrine System

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Thyroid Hormone Syn<strong>the</strong>sis<br />

Copyright © The McGraw-Hill Companies, Inc. Permission required for reproduction or display.<br />

Thyroid follicle<br />

Blood capillary<br />

Transport<br />

proteins<br />

I −<br />

Iodide<br />

1 Iodide absorption and oxidation<br />

5<br />

1<br />

Follicle cell<br />

2 Thyroglobulin syn<strong>the</strong>sis and secretion<br />

T 3<br />

T 4<br />

3 Iodine added <strong>to</strong> tyrosines of thyroglobulin<br />

4<br />

Thyroglobulin uptake and hydrolysis<br />

Lysosome<br />

4<br />

I –<br />

2<br />

Thyroglobulin<br />

5 Release of T 4 and a small amount of T 3 in<strong>to</strong><br />

<strong>the</strong> blood<br />

I *<br />

Iodine<br />

S<strong>to</strong>red<br />

thyroglobulin<br />

3

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