An Introduction to the Endocrine System
An Introduction to the Endocrine System
An Introduction to the Endocrine System
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Hormone Clearance<br />
• hormone signals must be turned off<br />
when <strong>the</strong>y have served <strong>the</strong>ir purpose<br />
• most hormones are taken up and<br />
degraded by liver and kidney<br />
– excreted in bile or urine<br />
• metabolic clearance rate (MCR)<br />
– rate of hormone removal from <strong>the</strong> blood<br />
– half-life - time required <strong>to</strong> clear 50% of<br />
hormone from <strong>the</strong> blood<br />
– faster <strong>the</strong> MCF, <strong>the</strong> shorter is <strong>the</strong> half-life
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