An Introduction to the Endocrine System
An Introduction to the Endocrine System
An Introduction to the Endocrine System
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Chemistry of Thyroid Hormone<br />
Copyright © The McGraw-Hill Companies, Inc. Permission required for reproduction or display.<br />
Thyroglobulin<br />
CH 2<br />
CH 2<br />
Tyrosine<br />
OH<br />
DIT<br />
l<br />
l<br />
OH<br />
+<br />
1<br />
Addition of iodine <strong>to</strong><br />
tyrosine <strong>to</strong> form MIT<br />
DIT<br />
l<br />
l<br />
OH<br />
3 Two DITs<br />
combine <strong>to</strong><br />
form thyroxine (T4)<br />
CH 2<br />
MIT<br />
CH 2<br />
I<br />
OH<br />
l<br />
l<br />
O<br />
OH<br />
l<br />
l<br />
2<br />
Addition of ano<strong>the</strong>r<br />
iodine <strong>to</strong> form DIT<br />
H 2 N<br />
H<br />
C<br />
4<br />
CH 2<br />
Thyroxine<br />
released from<br />
thyroglobulin<br />
COOH<br />
CH 2<br />
DIT<br />
Figure 17.19<br />
l<br />
l<br />
OH<br />
MIT contains one iodine a<strong>to</strong>m, DIT has two<br />
T 3 - combination of MIT plus DIT<br />
T 4 - combination of two DITs<br />
l<br />
l<br />
O<br />
l<br />
l<br />
OH
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