An Introduction to the Endocrine System
An Introduction to the Endocrine System
An Introduction to the Endocrine System
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O<strong>the</strong>r Second Messengers<br />
Diacylglycerol (DAG) pathway<br />
Inosi<strong>to</strong>l triphosphate (IP 3 ) pathway<br />
1<br />
Hormone<br />
Ca 2+ -gated<br />
ion channel<br />
Ca 2+<br />
IP 3 -gated Ca 2+ channeI<br />
Hormone<br />
1<br />
Recep<strong>to</strong>r<br />
Phospholipase<br />
Phospholipase<br />
Recep<strong>to</strong>r<br />
3<br />
DAG<br />
G<br />
IP G<br />
3<br />
G<br />
4 6<br />
2 2<br />
Inactive Activated<br />
8<br />
5<br />
PK<br />
PK<br />
G<br />
Various<br />
metabolic<br />
effects<br />
Enzyme<br />
Activated<br />
PK<br />
9<br />
10<br />
Calmodulin<br />
Ca 2+<br />
IP 3<br />
IP 3<br />
7<br />
Hormones<br />
ADH<br />
TRH<br />
OT<br />
LHRH<br />
Catecholamines<br />
Key<br />
DAG<br />
G<br />
IP 3<br />
PK<br />
Diacylglycerol<br />
G protein<br />
Inosi<strong>to</strong>l triphosphate<br />
Protein kinase<br />
Inactive<br />
PK<br />
Smooth<br />
ER<br />
• diacylglycerol (diglyceride) second-messenger system<br />
• inosi<strong>to</strong>l triphosphate second-messenger system<br />
• act on cell metabolism in a variety of ways
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