Change Of Diet For children With Autism Suffering - Nutrition and ...

had near-average levels. DISCUSSION: The finding of high vitamin B(6) levels is
consistent with recent reports of low levels of pyridoxal-5-phosphate and low
activity of pyridoxal kinase (i.e., pyridoxal is only poorly converted to pyridoxal-5phosphate,
the enzymatically active form). This may explain the functional need
for high-dose vitamin B(6) supplementation in many children and adults with
autism.
Tags: Female; Male
Descriptors: *Autistic Disorder--drug therapy--DT; *Child Behavior--drug effects-
-DE; *Trace Elements--therapeutic use--TU; *Vitamins--therapeutic use--TU ;
Adult; Child; Child, Preschool; Dietary Supplements; Dose-Response Relationship,
Drug; Double-Blind Method; Humans; Pilot Projects; Time Factors; Treatment
Outcome; Vitamin B 6--therapeutic use--TU
CAS Registry No.: 0 (Trace Elements); 0 (Vitamins); 8059-24-3 (Vitamin B 6)
Record Date Created: 20050127
Record Date Completed: 20050519
Spontaneous mucosal lymphocyte cytokine profiles in
children with autism and gastrointestinal symptoms:
mucosal immune activation and reduced counter
regulatory interleukin-10.
Ashwood Paul; Anthony Andrew; Torrente Franco; Wakefield Andrew J
Centre for Paediatric Gastroenterology, Royal Free and University College Medical
School, London, United Kingdom. pashwood@ucdavis.edu
Journal of clinical immunology ( United States ) Nov 2004 , 24 (6) p664-73 ,
ISSN: 0271-9142--Print Journal Code: 8102137
Publishing Model Print
Document type: Journal Article; Research Support, Non-U.S. Gov't
Languages: ENGLISH
Main Citation Owner: NLM
Record type: MEDLINE; Completed
Subfile: INDEX MEDICUS
A lymphocytic enterocolitis has been reported in a cohort of children with autistic
spectrum disorder (ASD) and gastrointestinal (GI) symptoms. This study tested
the hypothesis that dysregulated intestinal mucosal immunity with enhanced proinflammatory
cytokine production is present in these ASD children. Comparison
was made with developmentally normal children with, and without, mucosal
inflammation. Duodenal and colonic biopsies were obtained from 21 ASD children,
and 65 developmentally normal paediatric controls, of which 38 had signs of
histological inflammation. Detection of CD3+ lymphocyte staining for spontaneous
intracellular TNFalpha, IL-2, IL-4, IFNgamma, and IL-10, was performed by
multicolor flow cytometry. Duodenal and colonic mucosal CD3+ lymphocyte
counts were elevated in ASD children compared with noninflamed controls
(p