Laboratory News & BioScience December 2016
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In association with The NZ Microbiological Society Inc. VOL. 22 No. 1 JUNE 2012 ISSN 1172-7101<br />
Issue 116 | <strong>December</strong> <strong>2016</strong><br />
THE MAGAZINE FOR LABORATORY PROFESSIONALS<br />
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NOW INCORPORATING<br />
Royal Society of New Zealand<br />
honours Dr Bruce Campbell<br />
Congratulations to Dr Bruce<br />
Campbell, chief operating officer<br />
of Plant & Food Research, on being<br />
awarded the prestigious Thomson<br />
Medal for <strong>2016</strong>.<br />
The Thomson Medal is awarded by the<br />
Royal Society of New Zealand to recognise<br />
outstanding contributions to science<br />
and technology. It was presented to Dr Campbell<br />
for his outstanding leadership in both the<br />
agricultural and horticultural sciences over 35<br />
years.<br />
The medal selection committee noted: “His<br />
leadership has had a positive impact on the<br />
New Zealand economy, including innovations<br />
in forages, wine, kiwifruit and avocado sectors,<br />
and he has fostered new science talent and<br />
linked science closely with business and the<br />
wider community.”<br />
They particularly noted his scientific leadership<br />
during the response to the kiwifruit<br />
bacterial disease Psa when it was discovered<br />
in New Zealand in 2010, which saw more than<br />
100 Plant & Food Research scientists mobilised<br />
to support Zespri and the kiwifruit industry in<br />
understanding and managing the devastating<br />
disease.<br />
As chief operating officer of Plant & Food Research,<br />
Dr Campbell leads a team of more than<br />
600 scientists across New Zealand, delivering<br />
research and innovation to support the sustainable<br />
growth of the plant and marine-based<br />
food sectors.<br />
He has worked highly successfully to build<br />
relationships and research programmes based<br />
on shared understanding of how science can<br />
partner with industry to achieve targets for economic,<br />
environmental and social sustainability,<br />
with a close alignment between science and<br />
business strategies. This has extended recently<br />
to building much closer links with Māori food<br />
businesses and the Māori economy.<br />
In his role, he acts as director for a number<br />
of industry organisations and science partnerships,<br />
including Forage Innovations Limited,<br />
the Bio-Protection Research Centre of Excellence<br />
and the Horticulture New Zealand Vegetable<br />
Research & Innovation Board. He was<br />
made a Fellow of the NZ Institute of Agricultural<br />
& Horticultural Science in 2014.<br />
Dr Campbell is a strong advocate for encouraging<br />
young people to build careers in the horticultural<br />
and wider food industries. He championed<br />
the development of the Plant & Food<br />
Research Summer Studentship Programme<br />
- which to date has seen more than 250 young<br />
scientists spend three months undertaking a<br />
research project at the Institute to gain insights<br />
into real life science and business activities –<br />
and the creation of scholarships that support<br />
young Māori and Pacific Island students in furthering<br />
their science education and careers.<br />
He was also instrumental in establishing the<br />
Joint Graduate School in Plant and Food Science<br />
with the University of Auckland, the first<br />
collaboration of its kind in New Zealand, and<br />
the Joint Graduate School of Horticulture and<br />
Food Enterprise with Massey University.<br />
On receiving the Thomson Medal, Dr Campbell<br />
said: “I am thrilled and humbled to receive<br />
this award. It is a credit to the many talented<br />
people I have been privileged to work with over<br />
Continued to page 3<br />
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NEW ZEALAND LABORATORY NEWS | NEW ZEALAND BIOSCIENCE<br />
ISSUE 116 | DECEMBER <strong>2016</strong><br />
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[ 2 ]
NEW ZEALAND LABORATORY NEWS | NEW ZEALAND BIOSCIENCE<br />
Reaching for the moon with NASA<br />
A Victoria University of Wellington<br />
PhD graduand is investigating what<br />
new information can be gained<br />
about moonquakes during his<br />
postdoctoral fellowship at NASA.<br />
Jesse-Lee Dimech, who is completing his<br />
PhD in Geophysics at Victoria, says seismic<br />
energy is useful for looking inside<br />
planets.<br />
“Using the energy from earthquakes, or<br />
in this case, moonquakes, we can gain insight<br />
into the composition and structure of<br />
the Moon.”<br />
Between 1969 and 1972, five of the Apollo<br />
missions successfully placed seismometers<br />
at landing sites on the Moon, which<br />
recorded ground motion and radioed this<br />
information back to Earth. Contained in this<br />
dataset are more than 13,000 moonquakes<br />
that were recorded up until 1977.<br />
“I’m working on categorising and detecting<br />
moonquakes using the Apollo seismic<br />
dataset, as well as some extra datasets not<br />
previously used for this purpose. This particular<br />
work is being done in collaboration<br />
with Dr Renee Weber, my advisor at NASA,<br />
and Dr Brigitte Knapmeyer-Endrun, a scientist<br />
at Germany’s Max Planck Institute for<br />
Solar System Research.<br />
“It's a great opportunity to work<br />
with some of the world's top planetary<br />
seismologists. By applying new seismic<br />
analysis techniques we may be able to learn<br />
new information about the Moon—even<br />
from such an old dataset,” says Mr Dimech.<br />
One of those new techniques is shear<br />
wave splitting analysis, a key research interest<br />
of Professor Martha Savage from Victoria’s<br />
School of Geography, Environment and<br />
Earth Sciences, who has collaborated with<br />
Mr Dimech to undertake the first shear wave<br />
splitting analysis off Earth.<br />
“When seismic waves travel through layers<br />
of rock they split in much the same way<br />
light does when it hits a crystal. By measuring<br />
how much splitting occurs, we can infer<br />
physical properties from the rock, such as<br />
stress and fracturing, the presence of fluids,<br />
and rock laminations,” says Mr Dimech.<br />
Another technique, developed by Victoria’s<br />
Associate Professors Richard Arnold and<br />
John Townend, is a statistical method of examining<br />
the geometry of the faults responsible<br />
for earthquakes.<br />
“I applied this technique in my PhD to<br />
Jesse-Lee Dimech<br />
earthquakes we found in the upper mantle—the<br />
layer beneath the crust—which<br />
was able to tell us what type of faults produced<br />
them. We will be using a modified<br />
version of this code to understand the type<br />
of faulting associated with ‘deep’ moonquakes,<br />
which are situated about halfway<br />
between the Moon’s surface and its core.<br />
“I’m continuing to work with Professor<br />
Savage and Associate Professor Arnold<br />
while I’m at NASA. New Zealand has some<br />
great scientific talent and I’m excited about<br />
maintaining these relationships and building<br />
new ones.”<br />
Some of the techniques Mr Dimech uses<br />
may also be useful in helping NASA learn<br />
about the composition of Mars when they<br />
land a seismometer there in two years’ time<br />
as part of the InSight mission to Mars.<br />
Australian-born Mr Dimech says he has<br />
loved space since he was a child, and a postdoctoral<br />
role at NASA is the culmination of a<br />
lifelong ambition.<br />
“I was actually pen pals with Australia’s<br />
first astronaut Andrew Thomas. We exchanged<br />
several letters when I was a kid,<br />
and I even talked to him on the phone once,<br />
as well as fellow astronaut John Glenn who<br />
just happened to be in the office at the time.<br />
They definitely inspired me. I was also the<br />
youngest member of an astronomy club.<br />
I’ve always been fascinated by NASA.”<br />
For more information contact Samantha<br />
Fisher, Communications Adviser, on 04-463<br />
5105 or samantha.fisher@vuw.ac.nz.<br />
ISSUE 116 | DECEMBER <strong>2016</strong><br />
Royal Society of New Zealand honours Dr Bruce Campbell<br />
From page 1<br />
the years.<br />
“I have focused my career on partnering<br />
science with users of new knowledge to enhance<br />
food, the environment and people. It is<br />
great to see this connectivity of science now<br />
PRODUCT NEWS<br />
gathering momentum to enrich our society<br />
and wellbeing.”<br />
Before his current role, Dr Campbell was<br />
general manager Science Operations at HortResearch,<br />
acting as interim CEO during the<br />
merger of HortResearch and Crop & Food Research<br />
in 2008 that formed Plant & Food Research.<br />
He began his career, after completing<br />
his PhD in the UK, as a scientist at DSIR Grasslands,<br />
then as Scientist and Science Leader at<br />
AgResearch.<br />
Dr Campbell received the Thomson Medal<br />
at the Royal Society Honours Dinner, held at<br />
the Transitional Cathedral in Christchurch.<br />
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[ 3 ]
NEW ZEALAND LABORATORY NEWS | NEW ZEALAND BIOSCIENCE<br />
ISSUE 116 | DECEMBER <strong>2016</strong><br />
Government commits another half-million<br />
dollars into SKA computing and software<br />
Government commits another halfmillion<br />
dollars into SKA computing<br />
and software<br />
[ 4 ]<br />
At the SKA site in South Africa, some of the SKA team in 2015, with Nicolas Erdody, Andrew Ensor (AUT) at left and Willem van<br />
Straten (AUT -sixth from the left), together with collaborators from Australia, Canada, South Africa and UK.<br />
Representatives of the AUT/Industry collaboration working on the SDP Computer System design, Andrew Ensor (Director HPC<br />
Research Lab AUT), TN Chan (Managing Director and System Architect Compucon NZ), Piers Harding (Senior Consultant Catalyst<br />
IT), Peter Baillie (Project Manager NZ SKA Alliance), Don Christie (Co-founder and Co-owner Catalyst IT), Nicolás Erdödy (Founder<br />
and CEO Open Parallel).<br />
The Square Kilometre Array will involve<br />
thousands of dishes across Australia<br />
and South Africa that will act as a giant<br />
radio telescope.<br />
The telescope, which will start partial<br />
operations in 2021 and have a lifetime of 50<br />
years, will help to create data images allowing<br />
scientists to see back to the early stages<br />
of the universe. https://www.youtube.com/<br />
watch?v=pOxohO7W4sk<br />
New Zealand is one of 10 countries with a<br />
key role in the project- with AUT and its High<br />
Performance Computing Research Lab leading<br />
the NZ SKA Alliance’s effort.<br />
The Ministry for Business, Innovation and<br />
Employment has contributed an additional<br />
488-thousand-dollars towards the research.<br />
That is on top of the previously invested<br />
$1.7M. That funding is targeting a collaboration<br />
between university researchers and NZ<br />
industry partners working on the computing<br />
aspects of the project – AUT, Catalyst IT,<br />
Compucon NZ, and Open Parallel.<br />
Together, they are helping to design the<br />
Science Data Processor for the SKA. It’s the<br />
Big Data supercomputer system that will<br />
have the processing power of 100 million<br />
computers. That’s because the telescope will<br />
be producing data equivalent to 100 times<br />
the global internet traffic.<br />
The collaboration is working on cuttingedge<br />
computer nodes, algorithms and software<br />
to ensure the supercomputer will keep<br />
up with the unprecedented data rates.<br />
The world doesn’t have computers capable<br />
of processing this extraordinary level<br />
of data yet, so AUT High Performance Computing<br />
Lab is using AUT’s radio telescopes<br />
at Warkworth for modelling the SKA’s demands.<br />
Dr Andrew Ensor is the head of AUT’s HPC<br />
Lab and the director of the NZ SKA Alliance.<br />
“The SKA represents numerous firsts for<br />
New Zealand, being the biggest Big Data<br />
project in the world, the largest Science project<br />
NZ has ever lead substantial parts of, one<br />
of the largest NZ involvements in an international<br />
ICT collaboration, and what is becoming<br />
the longest term NZ academic-industry<br />
project collaboration.”<br />
Pro Vice Chancellor of Research and Innovation<br />
at AUT, Professor John Raine, says it’s<br />
great to see the government continuing to<br />
invest in the project.<br />
“NZ’s work on the SKA project is creating<br />
lasting research relationships in New Zealand<br />
and abroad and creating jobs and intellectual<br />
property that will outlive the SKA.”<br />
A director at Catalyst IT, Don Christie, is<br />
delighted Catalyst IT is now able to get more<br />
involved<br />
"Catalyst IT is now able to get more involved<br />
in the project, bringing valuable<br />
OpenStack cloud expertise as Australasia’s<br />
largest open source software company."<br />
Compucon’s Managing Director TN Chan<br />
says they’ve been working on the SKA since<br />
2013.<br />
“Compucon New Zealand has always<br />
been taking a role in computing node architecture<br />
investigations. We will stay in this<br />
area and at the same time develop an industry<br />
level ecosystem in New Zealand which<br />
did not exist before. “<br />
Nicolás Erdödy the CEO of Open Parallel,<br />
which is based in Oamaru, says they’ve had<br />
up to a dozen people working on the SKA<br />
computing work for the past six years.<br />
“This new funding will allow Open Parallel<br />
to employ new staff in Otago, increase its<br />
global collaboration already in place with<br />
top universities in New Zealand and overseas,<br />
boost our partnership with multinationals<br />
towards the SKA construction tender<br />
of 2018 and continue our R&D on applications<br />
of our work in the SKA compute platforms<br />
for NZ primary industries.”
NEW ZEALAND LABORATORY NEWS | NEW ZEALAND BIOSCIENCE<br />
Victoria research flourishes in Marsden funding<br />
Victoria University of Wellington<br />
researchers have received 26<br />
prestigious Marsden Fund grants<br />
worth $14.3 million, the largest<br />
number ever received by the<br />
University and more than 22 percent<br />
of the total funding awarded in <strong>2016</strong>.<br />
The Marsden Fund supports research<br />
excellence, allowing New Zealand’s<br />
most talented researchers to explore<br />
ideas at the forefront of their disciplines.<br />
The Fund is administered by the Royal Society<br />
of New Zealand on behalf of the Government.<br />
Victoria University researchers received<br />
22.2 percent of total Marsden grants, securing<br />
26 out of the 117 research projects<br />
funded nationwide.<br />
Victoria projects awarded funding<br />
range from research into nanoparticles,<br />
glaciers and election turnouts to gender,<br />
Māori traditional calendars and the cosmic<br />
web.<br />
Of the 26 successful Victoria researchers,<br />
16 are in the Faculty of Science, and six<br />
of those are in the School of Chemical and<br />
Physical Sciences.<br />
Four grants were awarded to researchers<br />
in the humanities, three to engineering<br />
staff, two for education research, and one<br />
to staff in the Faculty of Law.<br />
The funding consists of 17 Standard<br />
grants for established researchers and<br />
nine Fast-Start grants for researchers early<br />
in their careers.<br />
Of particular note is the $565,000<br />
awarded to Professor Rod Downey for a<br />
project titled ‘The mathematics of computation’.<br />
This is Professor Downey’s ninth<br />
Marsden grant as a Principal Investigator,<br />
putting him among an elite group of researchers<br />
to consistently win funding over<br />
many years.<br />
Vice-Provost (Research) Professor Kate<br />
McGrath says the results are excellent and<br />
confirm the strength of research capability<br />
at Victoria.<br />
“These successful projects reflect the<br />
world-leading and potentially gamechanging<br />
research being carried out at<br />
Victoria.<br />
“A particular highlight is Victoria’s growing<br />
reputation as a leader in the physical<br />
and chemical sciences, with staff in this<br />
area awarded Marsden funding of just under<br />
$4.5 million. In addition, the two grants<br />
awarded to researchers from the Faculty of<br />
Education is notable and an outstanding<br />
achievement.<br />
“As a global-civic capital city university,<br />
we want to lead thinking on major societal,<br />
economic and environmental issues.<br />
This success gives us assurance that our<br />
research is of the highest calibre.”<br />
Victoria University recipients of Marsden<br />
Grants (with funds to be distributed<br />
over three years) are:<br />
Standard grants:<br />
• Dr Shen Vun Chong (Robinson Research<br />
Institute): Nanostructuring in iron-based<br />
wires for ultra-high current density,<br />
$720,000<br />
• Dr Joel Colon-Rios (Law): Constituent<br />
power and the law, $420,000<br />
• Professor Carmen Dalli (Education): War<br />
and peace in the nursery: How do young<br />
children negotiate conflict to establish<br />
belonging and wellbeing in a multi-ethnic<br />
New Zealand early childhood centre,<br />
$735,000<br />
• Professor Simon Davy (Biological Sciences):<br />
From parasitism to mutualism: Symbiosis<br />
interaction states and the adaptability<br />
of reef corals to climate change,<br />
$830,000<br />
• Professor Rod Downey (Mathematics and<br />
Statistics): The mathematics of computation,<br />
$565,000<br />
• Dr Pauline Harris (Chemical and Physical<br />
Sciences): Ngā Takahuringā ō te ao: The<br />
Continued on page 6<br />
ISSUE 116 | DECEMBER <strong>2016</strong><br />
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, Turbidity<br />
pH, DO, NO 3<br />
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Gas Analysis: Measurement & Alarm - example O 2<br />
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[ 5 ]
NEW ZEALAND LABORATORY NEWS | NEW ZEALAND BIOSCIENCE<br />
ISSUE 116 | DECEMBER <strong>2016</strong><br />
Nelson Marlborough Health follows suit<br />
with RACS Respect Agreement<br />
A Memorandum of Understanding<br />
(MoU) aimed at building respect<br />
and improving patient safety in<br />
surgery has been signed between<br />
the Royal Australasian College<br />
of Surgeons (RACS) and Nelson<br />
Marlborough Health (NMH).<br />
The MoU, a collaboration formed<br />
under the RACS 2015 Action Plan:<br />
Building Respect, Improving Patient<br />
Safety, commits both organisations to<br />
a shared vision to provide high quality<br />
training, education and experience in the<br />
practice of surgery and is the second to<br />
be signed in New Zealand, following an<br />
agreement struck with the University of<br />
Otago last month.<br />
RACS and NMH will work together to<br />
ensure that surgical supervisors have the<br />
necessary skills and attributes and are<br />
supported to provide training, assessment,<br />
feedback and support to Trainees<br />
and International Medical Graduates free<br />
of discrimination, bullying and sexual harassment.<br />
RACS vice-president Professor Spencer<br />
Beasley said the College strongly supported<br />
NMH’s efforts.<br />
“RACS and NMH strongly support the<br />
rights of all healthcare professionals to<br />
a safe training and work environment<br />
where they can realise their full potential,”<br />
he said.<br />
"We know that if we can improve the<br />
culture of medicine, and surgery in particular,<br />
we can expect better patient outcomes.<br />
This is a powerful reason why we<br />
wish to work together with this initiative."<br />
Acting NMH CEO Peter Bramley says<br />
that the agreement will strengthen Nelson<br />
Marlborough Health’s initiatives to<br />
improve patient safety and its overall<br />
workplace culture.<br />
“Under the agreement, we will further<br />
develop programs and processes to address<br />
inappropriate staff behaviour across<br />
our hospitals, as well as aligning existing<br />
policies and processes to deal with these<br />
concerns,” Mr Bramley said.<br />
Specific initiatives include:<br />
• Sharing relevant information and resources<br />
regarding the education and<br />
training available with the respective<br />
institutions.<br />
• Exploring models for less than full-time<br />
training for surgical trainees and to promote<br />
these to allow greater flexibility<br />
and fulfilment of family commitments .<br />
Victoria research flourishes in Marsden funding<br />
From page 5<br />
effect of climate change on traditional<br />
Māori calendars, $720,000<br />
• Dr Justin Hodgkiss (Chemical and Physical<br />
Sciences): The origin of UV photoprotection<br />
in the brown skin pigment eumelanin,<br />
$870,000<br />
• Associate Professor Melanie Johnston-<br />
Hollitt (Chemical and Physical Sciences):<br />
Mapping the cosmic web with the Murchison<br />
Widefield Array, $870,000<br />
• Professor Estate Khmaladze (Mathematics<br />
and Statistics): On the theory of distribution-free<br />
tests for statistical hypothesis<br />
and unitary operators in functional spaces,<br />
$585,000<br />
• Professor Bastiaan Kleijn (Engineering and<br />
Computer Science): Distributed processing<br />
with information privacy in sensor<br />
networks, $790,000<br />
• Professor Eric Le Ru (Chemical and Physical<br />
Sciences): Probing the optical absorption<br />
of molecules adsorbed on metallic<br />
nanoparticles, $840,000<br />
• Associate Professor Ivy Liu (Mathematics<br />
and Statistics): Dimension reduction for<br />
mixed type multivariate data, $550,000<br />
• Dr Peter Ritchie (Biological Sciences): Testing<br />
for fishing-induced evolution using<br />
DNA from ancient and modern snapper,<br />
$830,000<br />
• Dr Sarah Ross (English, Film, Theatre and<br />
Media Studies): ‘Woe is me': Women and<br />
complaint in the English Renaissance,<br />
[ 6 ]<br />
$450,000<br />
• Associate Professor Jeff Sissons (Social<br />
and Cultural Studies): The mysterious disappearance<br />
of tuuaahu, $390,000<br />
• Dr Mattie Timmer (Chemical and Physical<br />
Sciences): The missing link: A traceless<br />
linking strategy for the conjugation of<br />
complex carbohydrates to proteins and<br />
peptides, $870,000<br />
• Professor Jack Vowles (History, Philosophy,<br />
Political Science and International Relations):<br />
A 'Big Data' approach to the problem<br />
of electoral turnout, $635,000<br />
Fast-Start grants:<br />
• Dr Shaun Eaves (Antarctic Research Centre):<br />
Establishing natural baselines of glacier<br />
variability in a warm world, $300,000<br />
• Dr Lorena Gibson (Social and Cultural<br />
Studies): East side orchestras: Music, poverty,<br />
and social change,<br />
$300,000<br />
• Dr Alia Martin (Psychology):<br />
Children's understanding<br />
of shared<br />
knowledge and its<br />
importance for effective<br />
communication,<br />
$300,000<br />
• Dr Yi Mei (Engineering<br />
and Computer Science):<br />
Automatic design of<br />
heuristics for dynamic<br />
arc routing problem with<br />
genetic programming,<br />
$300,000<br />
• Dr Polly Stupples (Geography, Environment<br />
and Earth Sciences): Stretching the<br />
celluloid ceiling: Women's creative agency<br />
in the emergent Pacific film industry,<br />
$300,000<br />
• Dr Tirta Susilo (Psychology): Fractionating<br />
face blindness: Creating a taxonomy for<br />
developmental prosopagnosia, $300,000<br />
• Dr Bronwyn Wood (Education): Citizenship<br />
in Aotearoa New Zealand: Young people,<br />
belonging and changing times, $300,000<br />
• Dr Bing Xue (Engineering and Computer<br />
Science): Large-scale evolutionary feature<br />
selection for classification, $300,000<br />
• Dr Cathie Zheng (Chemical and Physical<br />
Sciences): Finding the needle by removing<br />
the haystack: Modeling diffuse foregrounds<br />
to detect the epoch of reionization,<br />
$300,000.<br />
laboratorynews<br />
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NEW ZEALAND LABORATORY NEWS | NEW ZEALAND BIOSCIENCE<br />
Unique NZ synthetic chemistry<br />
scientist wins award<br />
The importance of fundamental<br />
science to expand new discoveries.<br />
Imagine a time before electronics, synthetic<br />
clothing, tyres, contact lenses or<br />
plastic products such as money, packaging<br />
and toys existed. This wide variety of<br />
man-made products has revolutionised our<br />
lives. But, what other materials are scientists<br />
capable of creating?<br />
That’s what Dr Erin Leitao, a chemical scientist<br />
from the University of Auckland won her<br />
award for, and her prize money will go into accelerating<br />
these yet to be seen materials.<br />
Dr Leitao is the <strong>2016</strong> New Zealand Fellow<br />
of the L’Oréal-UNESCO For Women in Science<br />
programme*, receiving a $25,000 grant to assist<br />
her independent research at the University<br />
of Auckland.<br />
For 18 years, the L’Oréal-UNESCO For<br />
Women in Science programme has supported<br />
women researchers around the world with<br />
the objective of recognising and rewarding<br />
their accomplishments whilst encouraging<br />
young women to enter the profession.<br />
“We are delighted to continue our support<br />
for a programme that recognises and<br />
rewards women for scientific excellence and<br />
for their contribution to society,” says Martin<br />
Smith Executive General Manager, L’Oréal<br />
New Zealand.<br />
“Research and innovation is at the heart<br />
of our business, so we are immensely proud<br />
to provide the opportunity to ensure that<br />
women are fairly represented at all levels in<br />
science.<br />
“Erin’s research is fundamental and time<br />
consuming so it is essential that we play<br />
our role to support new research solutions<br />
to help solve the world’s most complex<br />
questions.<br />
“It gives us great pleasure to present her<br />
with the L'Oréal-UNESCO For Women in Science<br />
New Zealand Fellowship for <strong>2016</strong>.”<br />
Dr Leitao is the only scientist in New Zealand<br />
working towards creating new polymeric<br />
materials with main-group elements<br />
comprising the backbone. The vast majority<br />
of synthetic chemistry is targeted at making<br />
molecules and materials containing predominantly<br />
carbon atoms.<br />
Dr Leitao wants to create new polymers<br />
by making use of main-group (inorganic) elements<br />
such as silicon, phosphorus, nitrogen,<br />
and oxygen. These alternatives to carbon are<br />
not only in high abundance, they give the<br />
potential to produce materials with unexplored<br />
properties and reactivity.<br />
Dr Leitao is investigating ways of creating<br />
new polymer building blocks and new ways<br />
in which to connect them.<br />
Dr Leitao says the materials resulting<br />
from the creation of synthetic polymers with<br />
main-group elements will give rise to new<br />
applications and a better understanding of<br />
the behaviour of the various main-group<br />
molecules and polymers.<br />
“It’s an under-explored area of science so<br />
there is potential to make significant discoveries.<br />
And that has the exciting prospect of<br />
one day putting New Zealand on the global<br />
map as a key player in main-group polymer<br />
chemistry, especially when it comes to commercializing<br />
new materials as there is a lot of<br />
support for that here,” she says.<br />
“The L’Oréal FWIS fellowship will help kickstart<br />
my independent research career as well<br />
as provide financial support which will make<br />
balancing a family and a career more effective.<br />
“Funding for basic science is crucial as we<br />
need it for new discoveries that enable new<br />
applications which haven't even been considered<br />
yet.<br />
“It is vital work and without it we could<br />
miss out on knowledge that will expand our<br />
understanding of science,” Dr Leitao says.<br />
“Currently we are working towards creating<br />
stable silicon based polymers which can conduct<br />
electricity that may be found in applications<br />
such as sensors or in electronic devices.”<br />
Canadian-born, Dr Leitao is a researcher<br />
and lecturer at the University of Auckland<br />
working in the School of Chemical Sciences<br />
on catalysis in inorganic and main group<br />
chemistry.<br />
Award winner: Dr Erin Leitao<br />
ISSUE 116 | DECEMBER <strong>2016</strong><br />
Guild congratulates Kiwi winners of Australia’s<br />
National Student Business Plan Competition<br />
The Pharmacy Guild of New Zealand<br />
congratulated the team from the University<br />
of Auckland which won the<br />
Pharmacy Guild of Australia’s National Student<br />
Business Plan Competition.<br />
The winning team of Akhila Puthigae,<br />
Surbhi Patel, Philip Cabasag and Sean Turner<br />
won with their fictitious NaturEd Pharmacy.<br />
NaturEd Pharmacy is based in Rotorua, and<br />
features a multilingual EduCare programme<br />
which revolutionises health literacy and patient<br />
education.<br />
The team was declared the competition<br />
winners at the recent <strong>2016</strong> Pharmacy Connect<br />
conference in Sydney. The two runners-<br />
up were Eye Scream for Eye Screens from<br />
the University of Technology Sydney, and<br />
One Life Pharmacy from the University of<br />
Sydney.<br />
The three finalists, from a total of 16 entries,<br />
successfully progressed through the<br />
business plan, quarter-final and semi-final<br />
rounds.<br />
They had to complete financial quizzes,<br />
write short answer essays about business<br />
finance and operations, and pitch their<br />
business ideas to the judges before being<br />
selected to pitch to the Pharmacy Connect<br />
conference delegates.<br />
Following the live pitches, each team<br />
met with the judging panel to answer some<br />
post-pitch questions about their business.<br />
The National Student Business Plan<br />
Competition is an initiative of the Pharmacy<br />
Guild of Australia designed to promote creative<br />
entrepreneurship among pharmacy<br />
students and encourage the development<br />
of viable, innovative, pharmacist-owned<br />
community pharmacies.<br />
The competition is open to all pharmacy<br />
schools across Australia and New Zealand<br />
and provides $15,000 in cash prizes to the<br />
finalists, a portion of which goes directly to<br />
the participating schools of pharmacy who<br />
produce the top three teams each year.<br />
[ 7 ]
NEW ZEALAND LABORATORY NEWS | NEW ZEALAND BIOSCIENCE<br />
ISSUE 116 | DECEMBER <strong>2016</strong><br />
Conductivity measurement is the<br />
easiest means of determining that<br />
the water purification system has<br />
produced water devoid of dissolved salts.<br />
Conductivity is a measure of water’s capability<br />
to pass electrical flow. Traditionally<br />
the measurement was as Resistivity, the water’s<br />
opposition to the flow of a current over<br />
distance. Both properties directly related<br />
to the concentration of ions in the water.<br />
These conductive ions typically come from<br />
dissolved salts and inorganic materials such<br />
as alkalis, Chlorides, Sulfides and Carbonate<br />
compounds.<br />
Conductivity is usually measured in micro-<br />
or milliSiemens per centimeter (uS/cm<br />
or mS/cm).<br />
Formally it is defined as the reciprocal of<br />
Resistivity, with Pure water having a resistance<br />
of 18.2 Mohm/cm. By nature resistivity<br />
and conductivity are reciprocals (1/measurement).<br />
The units name Mho and Ohm<br />
are the same letters, in reverse.<br />
A competent laboratory’s pure water QA<br />
program must include having a conductivity<br />
meter on hand. However the laboratory<br />
is faced with two problems.<br />
Firstly, most conductivity meters are<br />
PRODUCT NEWS<br />
Verifying the Quality of <strong>Laboratory</strong><br />
Deionised / Distilled Water<br />
made to work over a wide<br />
range, from tap water up to<br />
brackish waters. With such a<br />
wide range this will stretch the<br />
instrument’s measuring ability.<br />
This is because without having<br />
the ability to select a more precise<br />
measurement cell having<br />
the range specific cell constant<br />
(basically a function of the cell’s<br />
electrode geometry), the readings<br />
will not be made to the instrument<br />
system’s optimum ability.<br />
The second problem the laboratory<br />
faces is the requirement for<br />
traceable calibration performed<br />
against a low value reference of 5uS/<br />
cm or less.<br />
Bell Technology now provides a<br />
solution to both these issues by offering<br />
a low cost conductivity dip-meter,<br />
Jenco’s newly released EC331 model<br />
(resolution 0.1uS/cm), with measuring cell<br />
specific for low conductivity (high resistance),<br />
that is to say of low Cell Constant.<br />
Perfect for pure water. We also provide a<br />
calibration service for the instrument using<br />
a traceable reference solution of 5 uS/<br />
cm and will offer this as an ongoing service<br />
through our calibration laboratory.<br />
For more information contact us via email<br />
info@belltechnology.co.nz<br />
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Vol. 25 No. 6 • <strong>December</strong> <strong>2016</strong><br />
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LN_BioSci_1216_FC_MD_Quickdrop_trsfr.indd 1<br />
29/11/<strong>2016</strong> 1:49:41 p.m.
NEW ZEALAND LABORATORY NEWS | NEW ZEALAND BIOSCIENCE<br />
VOL. 25 NO. 6 | DECEMBER <strong>2016</strong><br />
New: 4 liter<br />
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Eppendorf® and the Eppendorf logo are registered trademarks of Eppendorf AG, Germany. U.S. Design Patents are listed on www.eppendorf.com/ip<br />
All rights reserved, including graphics and images. Copyright © <strong>2016</strong> by Eppendorf AG.<br />
Watch video!
NEW ZEALAND LABORATORY NEWS | NEW ZEALAND BIOSCIENCE<br />
Small and extremely resilient<br />
– the secrets of black fungi<br />
Highly resistant to stresses, black<br />
fungi are real champions among<br />
microorganisms. With the support<br />
of the Austrian Science Fund FWF, a<br />
research team in Vienna discovered<br />
that the fungi owe their qualities<br />
to hitherto unknown proteins and<br />
special processes at cellular level.<br />
They are true survival artists, not minding<br />
the cold any more than they do<br />
heat.<br />
Whether their environment offers little or<br />
plentiful oxygen, is wet, salty, dry or has contaminated<br />
soils – the black fungi keep their<br />
cool and feel at home in even the most inhospitable<br />
of living conditions.<br />
How do they do that?<br />
"To our great surprise, the fungi show<br />
almost no stress response at all. This means<br />
something in their structure makes them<br />
inherently resistant to stress," relates Katja<br />
Sterflinger.<br />
With the support of the Austrian Science<br />
Fund FWF, the microbiologist used a climate<br />
chamber to simulate different stress situations<br />
as the fungi encounter them in climatically<br />
extreme regions such as the Arctic or<br />
deserts. She first observed how the cells of<br />
the fungi, or, more precisely, its proteins, react<br />
to cold, heat, ozone or aridity.<br />
UNIQUE "PROTEIN TOOL"<br />
Katja Sterflinger heads the "Extremophile<br />
Center" at the Vienna Institute of BioTechnology<br />
(VIBT), University of Natural Resources<br />
and Life Science.<br />
The climate chambers, built specifically<br />
for the Institute, and the use of cutting-edge<br />
sequencing technologies have made it possible<br />
for the first time to identify the proteins<br />
of black fungi.<br />
"This was very difficult, because they are<br />
not like or even comparable to anything else<br />
we have seen so far," notes Sterflinger.<br />
The researchers have now learned that<br />
the "microcolonial fungi", as the technical<br />
term goes, have a unique protein system that<br />
enables them to grow both at 0° C or at 45° C.<br />
The microbes even survived a simulated<br />
trip to Mars. All it takes them to achieve that<br />
is some minor molecular adjustment.<br />
"Depending on whether it is hot or cold,<br />
the fungi will change a little. But that is just<br />
fine-tuning,” said Sterflinger.<br />
This is actually a very smart move on<br />
the part of the fungi, because any dramatic<br />
changes would consume energy.<br />
The fungi have no need for that and there-<br />
fore remain active even in low-nutrient environments<br />
such as glaciers or stone.<br />
UNDERSTANDING CELLULAR PROCESSES<br />
In a next step, the team headed by Sterflinger<br />
matched the protein data yield with<br />
the transcriptome data, i.e. they analysed the<br />
sequence of cellular processes.<br />
The researchers discovered that the cellular<br />
secret seems to be less related to the<br />
proteins than to the non-coding RNA (ribonucleic<br />
acid).<br />
These molecules are active in the cell<br />
without being translated into proteins.<br />
While their biological functions had been<br />
largely undetermined until recently, it is now<br />
known that they have an important role in<br />
regulating a variety of cellular processes.<br />
After all, only two percent of the genetic<br />
material that is actively read is translated into<br />
proteins.<br />
THE EXCEPTIONAL TALENT OF<br />
"EXOPHIALA DERMATITIDIS"<br />
Among the hundreds of fungal strains the<br />
Viennese researchers have investigated to<br />
date, "Exophiala dermatitidis" has turned out<br />
to be a particularly versatile extremophile.<br />
This microfungus, also known as 'black<br />
yeast', is found across all temperature ranges<br />
from cold to warm and withstands simply everything.<br />
"It grows on glaciers just as in saunas, and,<br />
unfortunately, also in our dishwashers. And it<br />
has the disagreeable property of being a human<br />
pathogen", explains Katja Sterflinger.<br />
This is the negative side of the fungus.<br />
On the plus side, it has an optimal talent<br />
for degrading hydrocarbons, i.e. toxins.<br />
This latter quality induced the microbiologists<br />
from the "Extremophile Center"<br />
to launch a second FWF-funded project in<br />
which they screened more than 200 black<br />
yeasts in their search for a biological "cleaner"<br />
for exhaust fumes and contaminated soils.<br />
Apart from "Exophiala" they found only<br />
one more fungus with the ability to degrade<br />
environmental toxins.<br />
Unfortunately, this second variety is also<br />
closely related to human pathogen strains,<br />
which meant that plans for using them as<br />
biofilters have been shelved for the time being.<br />
MEDICAL FOCUS<br />
Instead, the experts from Vienna's University<br />
of Natural Resources and Life Science<br />
now focus on medical issues and have set out<br />
to investigate the molecules of the pathogenic<br />
"Exophiala dermatitidis" more closely,<br />
since the fungus not only provokes infections<br />
in people with weak immune systems,<br />
but also increasingly in individuals of average<br />
good health, as Sterflinger notes, underlining<br />
the relevance of her research for medical science.<br />
According to the microbiologist, the extreme<br />
stress tolerance of the fungus is probably<br />
related to its pathogenicity.<br />
"This is an area we still don't know enough<br />
about. It is our goal to find out more about<br />
the virulence factors of the fungus."<br />
Personal details<br />
Katja Sterflinger is the head of the Extremophile<br />
Center (http://www.extremophilecenter.at)<br />
at the Vienna Institute of BioTechnology<br />
(VIBT), University of Natural Resources<br />
and Life Science. The microbiologist specialises<br />
in the study of fungi and black yeasts<br />
and as such is a sought-after expert when it<br />
comes, for instance, to the preservation of<br />
monuments.<br />
Scientific Contact:<br />
Assoc. Prof. Dr. Katja Sterflinger<br />
Institute of Biotechnology<br />
University of Natural Resources and Life Sciences<br />
Vienna Muthgasse 18, 1190 Vienna T<br />
+43 / 1 / 47654-79862 E katja.sterflinger@<br />
boku.ac.at W http://www.boku.ac.at/en/<br />
Publications<br />
Blasi, B; Poyntner, C; Rudavsky, T; Prenafeta-<br />
Boldú, FX; Hoog, S; Tafer, H; Sterflinger, K:<br />
Pathogenic Yet Environmentally Friendly?<br />
Black Fungal Candidates for Bioremediation<br />
of Pollutants, in: Geomicrobiology<br />
Journal <strong>2016</strong>; 33(3-4):308-317, doi:<br />
10.1080/01490451.2015.1052118 http://<br />
www.tandfonline.com/doi/full/10.1080/014<br />
90451.2015.1052118?scroll=top&needAcces<br />
s=true<br />
Blasi, B; Tafer, H; Tesei, D; Sterflinger, K: From<br />
Glacier to Sauna: RNA-Seq of the Human<br />
Pathogen Black Fungus Exophiala dermatitidis<br />
under Varying Temperature Conditions<br />
Exhibits Common and Novel Fungal Response,<br />
in: PLoS One. 2015; 10(6):e0127103,<br />
doi: 10.1371/journal.pone.0127103<br />
http://journals.plos.org/plosone/<br />
article?id=10.1371/journal.pone.0127103<br />
Tesei, D; Marzban, G; Marchetti-Deschmann,<br />
M; Tafer, H; Arcalis, E; Sterflinger, K: Proteome<br />
of tolerance fine-tuning in the human pathogen<br />
black yeast Exophiala dermatitidis, in:<br />
Journal of Proteomics. 2015; 128:39-57, doi:<br />
10.1016/j.jprot.2015.07.007<br />
https://www.ncbi.nlm.nih.gov/<br />
pubmed/26189359<br />
Zakharova, K; Tesei, D; Marzban, G; Dijksterhuis,<br />
J; Wyatt, T; Sterflinger, K: Microcolonial<br />
fungi on rocks: a life in constant drought?, in:<br />
Mycopathologia. 2013; 175(5-6):537-547, doi:<br />
10.1007/s11046-012-9592-1<br />
https://www.ncbi.nlm.nih.gov/<br />
pubmed/23073825<br />
[ 3 ]<br />
VOL. 25 NO. 6 | DECEMBER <strong>2016</strong>
NEW ZEALAND LABORATORY NEWS | NEW ZEALAND BIOSCIENCE<br />
VOL. 25 NO. 6 | DECEMBER <strong>2016</strong><br />
Bioelectronic therapy effective for patients<br />
with medically unexplained symptoms<br />
An observational study presented<br />
at the at the International Society<br />
for Pharmacoeconomics and<br />
Outcomes Research (ISPOR) 19th<br />
Annual European Congress has<br />
found that non-invasive vagus<br />
nerve stimulation is an effective<br />
treatment for patients with<br />
medically unexplained symptoms.<br />
The study also showed that nVNS treatment<br />
significantly reduced the total<br />
number of GP appointments and hospital<br />
referrals required by these patients. A<br />
second poster presented by the York Health<br />
Economics Consortium (YHEC), supported by<br />
a grant from the Yorkshire and Humber Academic<br />
Health Science Network, calculated<br />
the study was cost-effective.<br />
The research has found that up to 66<br />
percent of patients who suffer from at least<br />
three of the following conditions, primary<br />
[ 4 ]<br />
headache, gastric motility disorders, anxiety,<br />
depression, and widespread chronic pain,<br />
experienced an improvement in their overall<br />
health following a medication review and<br />
after they started nVNS treatment with electroCore’s<br />
gammaCore device. Sixty percent<br />
of adult primary headache patients have one<br />
or more other medically unexplained symptoms<br />
[1] .<br />
Approximately 25 percent of all GP consultations,<br />
and 25 percent of all hospital referrals,<br />
are generated by 10 percent of the<br />
18 to 70-year-old UK patient population who<br />
suffer from multiple medically unexplained<br />
symptoms. As a result of the study there was<br />
a 19 percent reduction in the number of GP<br />
appointments attended by the patients, and<br />
a 23 percent reduction in their number of<br />
hospital referrals.<br />
This study comes in the light of recently<br />
published NICE guidelines describing the<br />
need to optimise the care received by patients<br />
with multimorbidity.<br />
NICE chairman Professor David Haslam<br />
Themis Bioscience successfully closes<br />
10 million euro financing round<br />
The fresh capital will be used to complete<br />
a phase 2 clinical trial of its lead<br />
product, a vaccine candidate against<br />
Chikungunya fever.<br />
Further products that will benefit include<br />
the company's Zika virus vaccine<br />
whose development just recently received<br />
significant financial support by Innovate<br />
UK.<br />
Dr Erich Tauber, CEO and co-founder of<br />
Themis, on the successful completion of<br />
the company's second financing round:<br />
"We are delighted about the continuous<br />
trust of our existing investors and of Austria's<br />
leading Venture Fund aws Gruenderfonds.<br />
“This trust and our recent excellent<br />
product development and technology<br />
progress have also attracted new investors<br />
and we are very grateful for their support."<br />
The now successfully closed investment<br />
round included the existing investors Ventech,<br />
Omnes Capital and Wellington Partners<br />
with the latter leading the round. New<br />
investors were undisclosed business angels<br />
with a focus on vaccine development and<br />
the aws Gruenderfonds.<br />
Dr Regina Hodits, general partner at the<br />
lead investor Wellington Partners, comments<br />
on their investment decision: "Themis'<br />
focus on prophylactic vaccines for<br />
emerging tropical infectious diseases, its<br />
patented platform technology and the recent<br />
very encouraging results from a phase<br />
1 clinical trial of its lead candidate make the<br />
company a very attractive investment opportunity.<br />
“We want the company's vaccine portfolio<br />
to develop at a fast pace and are willing<br />
and determined to support Themis on its<br />
growth path."<br />
At the heart of Themis' success lies the<br />
company's proprietary Themaxyn® platform.<br />
It uses a standard measles virus<br />
vaccine as a vector, developed at Institut<br />
Pasteur in Paris, and constitutes the basis<br />
of the company's pipeline. As measles vaccines<br />
have been successfully used in hundreds<br />
of millions of people globally, the<br />
Themaxyn® platform offers an excellent<br />
safety profile and clear advantages in terms<br />
of a validated, low-cost production process.<br />
Recent phase 1 clinical trial results of the<br />
company's lead product, a Chikungunya<br />
vaccine, proved the suitability of the vector<br />
for other indications and the observed<br />
immune responses encouraged the management<br />
to move this vaccine candidate<br />
rapidly to a phase 2 trial, which has been<br />
initiated earlier this year.<br />
Continued on page 5<br />
commented: “Actually now many patients<br />
have multiple problems. People don’t die but<br />
live with multiple diseases. Now we need to<br />
build care around these people - and the vital<br />
increasing role of the generalist comes along<br />
with this.” [2]<br />
The study was carried out in seven primary<br />
care practices across the UK by expert<br />
pharmacists from Interface Clinical Services.<br />
A total of 233 patients, who used the gammaCore<br />
nVNS device alongside their existing<br />
treatments, were assessed after periods of<br />
eight weeks and 40 weeks using the EQ-5D-<br />
5L quality of life index. Patients reported less<br />
pain and discomfort, and improved ability to<br />
perform their normal daily activities, as well<br />
as lower levels of anxiety and depression.<br />
Patients were asked to self-administer<br />
three nVNS doses per day, with each dose<br />
equalling two minutes of electrical stimulation<br />
to the vagus nerve. Interface pharmacists<br />
provided training to patients on how<br />
to use the gammaCore device. The patients<br />
found the therapy very easy to use at home,<br />
and reported no serious side effects.<br />
Dr. James Ward, GP and GPwSI in Headache<br />
at Oaklands Health Centre, West Yorkshire,<br />
said: “We introduced this service into<br />
practice in 2014 and as a result have improved<br />
the way we manage patients with complex<br />
medically unexplained symptom multimorbidity.<br />
Whilst the patients are benefiting from<br />
having a better quality of life, we as GPs benefit<br />
from knowing that patients feel empowered<br />
to better manage their health at home.”<br />
About electroCore<br />
ElectroCore LLC, the New Jersey based<br />
bioelectric pharma company, is focused on<br />
developing non-invasive vagus nerve stimulation<br />
therapies (the gammaCore device)<br />
for the treatment of multiple conditions in<br />
neurology, psychiatry, gastroenterology, and<br />
respiratory fields. The company’s initial target<br />
is the treatment of primary headaches<br />
(migraine and cluster headache), and the<br />
associated chronic co-morbidities of gastric<br />
motility, psychiatric, sleep, and pain disorders<br />
that drive disproportionately large direct and<br />
indirect costs within the healthcare system<br />
and society.<br />
GammaCore is available in the UK. In Germany<br />
gammaCore is distributed by Desitin.<br />
In the USA electroCore is awaiting FDA approval.<br />
[1] http://www.ecorelibrary.com/landing/<br />
pdf/GNS_001558_Poster_26Sept<strong>2016</strong>_FI-<br />
NAL.pdf<br />
[2] http://www.gponline.com/nhs-redesigncare-around-multimorbidity-nice-experts-warn/article/1411511
NEW ZEALAND LABORATORY NEWS | NEW ZEALAND BIOSCIENCE<br />
Themis Bioscience successfully<br />
closes 10 million euro financing round<br />
From page 4<br />
This progress not only pleased existing<br />
investors but also raised the interest of new<br />
ones such as the aws Gruenderfonds. Ralf<br />
Kunzmann, CEO of aws Gruenderfonds,<br />
comments: "We‘re happy to support Erich<br />
Tauber and his team in the further development<br />
of the promising prophylactic vaccines<br />
for emerging tropical infectious diseases<br />
and to be part of the strong investor<br />
syndicate. We are looking forward to take<br />
the next steps together with Themis."<br />
Dr Gerd Zettlmeissl, chairman of the supervisory<br />
board of Themis, comments on<br />
the future company plans: "We are grateful<br />
for the trust of our existing and new investors<br />
and I am pleased to welcome Ralf Kunzmann<br />
of the aws Gruenderfonds as a new<br />
member of our supervisory board.<br />
“The new capital will primarily be dedicated<br />
to finalise the phase 2 clinical trial of<br />
our Chikungunya vaccine and to prepare<br />
for respective phase 3 trials.” Furthermore,<br />
Themis will use the additional investment<br />
to continue the exploitation of the knowhow<br />
it acquired with the Chikungunya vaccine's<br />
development for further prophylactic<br />
vaccines. These include a vaccine against<br />
the Zika virus whose advance into the clinical<br />
trial phase by Themis was recently supported<br />
by the United Kingdom's innovation<br />
agency, Innovate UK, with 1 Mio. GBP.<br />
About Themis (November <strong>2016</strong>):<br />
Themis Bioscience GmbH develops prophylactic<br />
vaccines from the preclinical to<br />
the early clinical phase, focusing on emerging<br />
tropical infectious diseases, with initial<br />
vaccine candidates currently being developed<br />
against Chikungunya and Zika. The<br />
company's highly innovative and fully patent-protected<br />
measles virus vaccine vector<br />
technology platform, licensed from the<br />
internationally respected Institut Pasteur in<br />
Paris, forms the basis for all current vaccine<br />
candidates of the Vienna-based company.<br />
www.themisbio.com<br />
About the vaccine technology<br />
(November <strong>2016</strong>):<br />
The scientific basis for Themis' measles<br />
vector Themaxyn® platform has been developed<br />
at the Institut Pasteur in Paris and<br />
is licensed to Themis. It relies on the use<br />
of the standard measles vaccine as a vaccination<br />
vector. Genes coding for selected<br />
antigens from the chikungunya virus have<br />
been inserted into the genome of this<br />
well-established vaccine. The measles-chikungunya<br />
vaccine delivers the chikungunya<br />
antigens directly to macrophages and<br />
dendritic cells – the most potent and effective<br />
antigen-presenting cells, thereby triggering<br />
a specific immune response to chikungunya<br />
virus. This results in a powerful,<br />
antigen-focused immune response, which<br />
is most likely to confer long-term immunity<br />
as does the measles vaccine.<br />
About aws Gruenderfonds<br />
(November <strong>2016</strong>):<br />
aws Gruenderfonds is Austrian's leading<br />
venture capital fund with around EUR<br />
70 M EUR under management. The parent<br />
company is the Austrian Wirtschaftsservice<br />
Gesellschaft mbH (aws). The fund invests<br />
in Austrian startups with high growth potential<br />
in their early growth or expansion<br />
stage. aws Gründerfonds is a long term<br />
partner who takes hands-on approach and<br />
actively assembles a syndicate of international<br />
co-investors out of their international<br />
network. Currently the fund has invested<br />
in 20 startups, further investments in the<br />
life science segment include e.g. Miracor<br />
Medical Systems and Panoptes.<br />
VOL. 25 NO. 6 | DECEMBER <strong>2016</strong><br />
Nikon's ALL NEW Inverted<br />
Microscope Platform for<br />
Advanced Imaging<br />
Eclipse Ti2<br />
Ground-breaking FOV 25mm<br />
Nikon Perfect Focus System<br />
Intelligent assist guide<br />
18mm<br />
25mm<br />
Routine Systems North Island | Melanie Kennerley | Ph: (021) 480 044<br />
Routine Systems South Island | Tony Bradshaw | Ph: (09) 292 7290<br />
Advanced Microscopy Systems | Dr Rob Woolley | Ph: (021) 288 8636<br />
sales@coherent.com.au | www.coherent.com.au<br />
[ 5 ]
NEW ZEALAND LABORATORY NEWS | NEW ZEALAND BIOSCIENCE<br />
VOL. 25 NO. 6 | DECEMBER <strong>2016</strong><br />
Ginolis launches revolutionary lateral flow<br />
device assembly solution<br />
Ginolis Ltd, a leading provider of high<br />
precision liquid handling and intelligent<br />
desktop automation for MedTech<br />
industries, recently announced the launch of<br />
the revolutionary LFDA-3, the intelligent lateral<br />
flow device assembly solution.<br />
The world leading lateral flow device assembly<br />
solution provides manufacturers flexible<br />
production capacity within a desktop<br />
footprint.<br />
The LFDA-3 is built on Ginolis´modular<br />
Xanthia robotic platform.<br />
The modular design provides speed, accuracy<br />
and precision, as well as flexibility for<br />
the future. The solution is easily adaptable and<br />
PRODUCT NEWS<br />
Thermo Scientific Smart-vue<br />
Wireless Sample Monitoring Solution<br />
Thermo Scientific Smart-Vue solutions<br />
protect precious samples by monitoring<br />
key laboratory parameters including<br />
temperature, CO2 concentration, humidity<br />
and differential pressure.<br />
The Smart-Vue solution can be installed on<br />
most laboratory equipment, including ultralow<br />
temperature freezers, laboratory refrigerators,<br />
CO2 incubators and in clean rooms.<br />
This intuitive, wireless monitoring solution is<br />
can assemble different rapid tests with minimal<br />
product specific adjustments. Machine<br />
vision guidance throughout the entire system<br />
ensures a consistent high quality assembled<br />
device.<br />
“The LFDA revolutionizes the rapid test<br />
manufacturing market. One system can assemble<br />
multiple rapid test devices with little<br />
or no changeover time,” states Jorma Venäläinen,<br />
VP of sales and marketing at Ginolis Ltd.<br />
“Vision guided component placement,<br />
strip cutting and assembly throughout the<br />
process ensures fast production times with<br />
high quality results.”<br />
The revolutionary new desktop solution<br />
designed for controlled laboratory environments<br />
such as pharmaceutical research and<br />
production, IVF clinics, tissue banking and<br />
diagnostic laboratories, where sample protection<br />
and monitoring is a priority. To facilitate<br />
regulatory compliance with various protocols,<br />
Smart-Vue provides full audit-trail traceability.<br />
By continuously monitoring ambient conditions,<br />
the Smart-Vue wireless monitoring<br />
solution protects sensitive laboratory samples<br />
comes equipped with machine vision guidance,<br />
real time quality control, bulk feeders,<br />
proprietary Ginger software and a host of additional<br />
features.<br />
The LFDA-3 is available with single card,<br />
card magazine or reel infeed.<br />
The desktop solution has an extremely<br />
quick changeover time and production capabilities<br />
up to 30 units/minute.<br />
The LFDA-3 allows you to realise all the<br />
benefits of automating your manufacturing<br />
process in a footprint that is less than three<br />
square meters.<br />
The company is showcasing the LFDA-3 for<br />
the first time at Medica trade fair in Düsseldorf,<br />
Germany on November 14 – 17. Visit Ginolis<br />
Ltd at Hall 1 stand B15.<br />
with immediate remote alarm notifications.<br />
It creates a permanent record of all readings,<br />
alarms and acknowledgements with the responder’s<br />
personal identification. It is accessible<br />
via the Internet anytime, anywhere.<br />
Smart-Vue can be easily installed, set up<br />
and maintained. The multilingual, user-installed<br />
software automatically identifies and<br />
pre-configures module protocols for easeof-use.<br />
The highly efficient and cost-effective<br />
Smart-Vue solution is fully scalable and flexible,<br />
and it is compatible with multiple brands<br />
and types of laboratory equipment.<br />
www.thermofisher.co.nz/<br />
wirelessmonitoring<br />
NEW from Molecular Devices: Rapid, accurate DNA, RNA,<br />
and protein quantitation in a one-touch, full-spectrum<br />
micro-volume absorbance reader<br />
The SpectraMax® QuickDrop Micro-Volume<br />
Spectrophotometer addresses the<br />
needs of life science researchers who<br />
[ 6 ]<br />
quantify very small amounts of DNA, RNA, oligos,<br />
and proteins. The QuickDrop Spectrophotometer<br />
allows you to set up your laboratory<br />
with a minimal investment of time, cost, and<br />
effort.<br />
Quantitate micro-volume samples with ease<br />
The QuickDrop Spectrophotometer provides<br />
you with the flexibility to work with your<br />
micro-volume samples in the platform that<br />
best suits your research. The built-in sample<br />
port allows you to work with volumes as small<br />
as 0.5 μL, preserving your precious samples,<br />
while the cuvette port lets you expand your<br />
work to include larger volume samples.<br />
The QuickDrop Spectrophotometer is a<br />
stand-alone unit with a small footprint and<br />
does not require a direct connection to a dedicated<br />
computer. The large, high-resolution<br />
touchscreen interface offers you the ability<br />
to take advantage of pre-configured analysis<br />
methods, set up your customized experiment<br />
with ease, or export your data to a USB flash<br />
drive for additional analysis.<br />
Increased sensitivity without sacrificing<br />
speed<br />
With a four second read time and no moving<br />
parts to skew the sample, or to potentially<br />
break, the QuickDrop Spectrophotometer<br />
maintains an accurate pathlength, providing<br />
you with results that are both fast and reliable,<br />
regardless of viscosity.<br />
For more information please contact Bio-<br />
Strategy<br />
T: 0800 34 24 66<br />
E: info@bio-strategy.com<br />
www.bio-strategy.com
NEW ZEALAND LABORATORY NEWS | NEW ZEALAND BIOSCIENCE<br />
VOL. 25 NO. 6 | DECEMBER <strong>2016</strong><br />
[ 7 ]
NEW ZEALAND LABORATORY NEWS | NEW ZEALAND BIOSCIENCE<br />
VOL. 25 NO. 6 | DECEMBER <strong>2016</strong><br />
First random laser made of paper-based ceramics<br />
A new biotemplating process<br />
makes it possible to create lasers<br />
out of cellulose paper.<br />
Working with physicists from the University<br />
of Rome, a team led by Professor<br />
Cordt Zollfrank from the Technical<br />
University of Munich (TUM) built the first<br />
controllable random laser based on cellulose<br />
paper in Straubing.<br />
The team thereby showed how naturally<br />
occurring structures can be adapted for technical<br />
applications.<br />
Hence, materials no longer need to be artificially<br />
outfitted with disordered structures,<br />
utilizing naturally occurring ones instead.<br />
Material synthesis that is inspired by biology<br />
is an area of research at TUM’s Chair of<br />
Biogenic Polymers at the Straubing Center<br />
of Science. It utilises models from nature and<br />
biogenic materials to develop new materials<br />
and technologies. The latest issue of the publication<br />
“Advanced Optical Materials” features<br />
a basic study by a joint team from Straubing<br />
and Rome who succeeded in “using a biological<br />
structure as a template for a technical<br />
random laser,” according to scientist Dr Daniel<br />
Van Opdenbosch.<br />
Two components are necessary for a laser:<br />
[ 8 ]<br />
PRODUCT NEWS<br />
Nikon’s all new Inverted Microscope<br />
Platform for advanced imaging – see<br />
more than before<br />
The Eclipse Ti2 delivers an unparalleled<br />
25mm field of view (FOV) that<br />
revolutionises the way you see. With<br />
this incredible FOV, the Ti2 maximises<br />
the sensor area of large-format CMOS<br />
cameras without making compromises, and<br />
significantly improves data throughput. The<br />
Ti2’s exceptionally stable, drift-free platform<br />
is designed to meet the demands of superresolution<br />
imaging while its unique hardware<br />
First of all, a medium which amplifies light.<br />
And secondly, a structure which retains the<br />
light in the medium.<br />
A classic laser uses mirrors to order and<br />
shine light in a single direction in a targeted,<br />
uniform fashion.<br />
This also takes place uniformly in the microscopic<br />
structure of a random laser, but in<br />
different directions.<br />
Although the development of the random<br />
laser is still in its infancy, in the future it could<br />
result in lower-cost production.<br />
This is because random lasers have the advantage<br />
that they are direction-independent<br />
and function with multiple colors, just to<br />
name a few benefits.<br />
Disordered structure deflects light in all<br />
directions<br />
“The prerequisite for a random laser is a<br />
defined degree of structural chaos on the<br />
interior,” Dr Van Opdenbosch explained. The<br />
light in a random laser is therefore scattered<br />
at all manner of angles along random paths,<br />
which are determined by an irregular structure<br />
in the interior of the medium. The team<br />
led by Professor Zollfrank from the Chair of<br />
Biogenic Polymers in Straubing used conventional<br />
laboratory filter paper as a structural<br />
template.<br />
“Due to its long fibers and the resulting<br />
triggering capabilities enhance even the<br />
most challenging, high-speed imaging<br />
applications. Furthermore, the Ti2’s unique,<br />
intelligent functions guide users through<br />
imaging workflows by gathering data from<br />
internal sensors, eliminating the possibility<br />
of user errors. In addition, the status of each<br />
sensor is automatically recorded during<br />
acquisition, providing quality control for<br />
imaging experiments and enhancing data<br />
reproducibility. In combination with Nikon’s<br />
powerful acquisition and analysis software,<br />
NIS-Elements, the Ti2 is a total innovation in<br />
imaging.<br />
Compact, High-Definition, High-Speed<br />
and High-Sensitivity C-mount Camera<br />
Nikon’s DS-Fi3 is a new high-definition<br />
colour microscope camera equipped with a<br />
5.9 megapixel CMOS image sensor. Its highspeed<br />
data readout, superior colour reproduction<br />
and high quantum efficiency are<br />
optimal for imaging in various observations,<br />
such as brightfield, DIC, phase contrast and<br />
fluorescence observation.<br />
The DS-Fi3 is equipped with a 5.9 mega-<br />
stable structure, we deemed it to be suitable<br />
for this purpose,” said Dr Van Opdenbosch.<br />
In the laboratory, the paper was impregnated<br />
with tetraethyl orthotitanate, an organometallic<br />
compound.<br />
When it is dried and the cellulose burned<br />
off at 500 degrees Celsius, it leaves behind the<br />
ceramic titanium dioxide as residue — the<br />
same substance generally used in sunblock to<br />
provide protection from the sun.<br />
“This effect in sunblock is based on titanium<br />
dioxide’s strong light scattering effect,”<br />
said Dr Van Opdenbosch, “which we also utilised<br />
for our random laser.<br />
“Our laser is ‘random’ because the light<br />
which is scattered in different directions due<br />
to the biogenic structure of the laboratory filter<br />
paper can also be scattered in the opposite<br />
direction,” he added, explaining the principle.<br />
Random laser not that random after all<br />
However, the light waves can still be controlled<br />
despite their random nature, as the<br />
team led by Claudio Conti of the Institute for<br />
Complex Systems in Rome discovered, with<br />
whom Daniel Van Opdenbosch and Cordt<br />
Zollfrank collaborated.<br />
With the help of a spectrometer, they were<br />
able to differentiate the various laser wavelengths<br />
generated in the material and localise<br />
them separately from one another.<br />
pixel CMOS image sensor, which enables<br />
the capture of high-definition images of<br />
up to 2880 x 2048 pixels. With a new CMOS<br />
image sensor and high-speed data transfer<br />
via USB3.0, the DS-Fi3 enables fast focusing<br />
even in high-resolution imaging, and efficient<br />
image acquisition when using a wide<br />
range of illumination techniques.<br />
For further information please contact<br />
Tony Bradshaw<br />
Coherent Scientific Pty Ltd<br />
tony.bradshaw@coherent.com.au<br />
www.coherent.com.au