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In association with The NZ Microbiological Society Inc. VOL. 22 No. 1 JUNE 2012 ISSN 1172-7101<br />

Issue 116 | <strong>December</strong> <strong>2016</strong><br />

THE MAGAZINE FOR LABORATORY PROFESSIONALS<br />

Never miss an issue… receive the latest Lab <strong>News</strong> and <strong>BioScience</strong><br />

straight to your inbox. Send your details to: Barb@wbn.co.nz<br />

Check out our facebook page: facebook.com/NZ<strong>Laboratory</strong>newsandNZ<strong>BioScience</strong><br />

NOW INCORPORATING<br />

Royal Society of New Zealand<br />

honours Dr Bruce Campbell<br />

Congratulations to Dr Bruce<br />

Campbell, chief operating officer<br />

of Plant & Food Research, on being<br />

awarded the prestigious Thomson<br />

Medal for <strong>2016</strong>.<br />

The Thomson Medal is awarded by the<br />

Royal Society of New Zealand to recognise<br />

outstanding contributions to science<br />

and technology. It was presented to Dr Campbell<br />

for his outstanding leadership in both the<br />

agricultural and horticultural sciences over 35<br />

years.<br />

The medal selection committee noted: “His<br />

leadership has had a positive impact on the<br />

New Zealand economy, including innovations<br />

in forages, wine, kiwifruit and avocado sectors,<br />

and he has fostered new science talent and<br />

linked science closely with business and the<br />

wider community.”<br />

They particularly noted his scientific leadership<br />

during the response to the kiwifruit<br />

bacterial disease Psa when it was discovered<br />

in New Zealand in 2010, which saw more than<br />

100 Plant & Food Research scientists mobilised<br />

to support Zespri and the kiwifruit industry in<br />

understanding and managing the devastating<br />

disease.<br />

As chief operating officer of Plant & Food Research,<br />

Dr Campbell leads a team of more than<br />

600 scientists across New Zealand, delivering<br />

research and innovation to support the sustainable<br />

growth of the plant and marine-based<br />

food sectors.<br />

He has worked highly successfully to build<br />

relationships and research programmes based<br />

on shared understanding of how science can<br />

partner with industry to achieve targets for economic,<br />

environmental and social sustainability,<br />

with a close alignment between science and<br />

business strategies. This has extended recently<br />

to building much closer links with Māori food<br />

businesses and the Māori economy.<br />

In his role, he acts as director for a number<br />

of industry organisations and science partnerships,<br />

including Forage Innovations Limited,<br />

the Bio-Protection Research Centre of Excellence<br />

and the Horticulture New Zealand Vegetable<br />

Research & Innovation Board. He was<br />

made a Fellow of the NZ Institute of Agricultural<br />

& Horticultural Science in 2014.<br />

Dr Campbell is a strong advocate for encouraging<br />

young people to build careers in the horticultural<br />

and wider food industries. He championed<br />

the development of the Plant & Food<br />

Research Summer Studentship Programme<br />

- which to date has seen more than 250 young<br />

scientists spend three months undertaking a<br />

research project at the Institute to gain insights<br />

into real life science and business activities –<br />

and the creation of scholarships that support<br />

young Māori and Pacific Island students in furthering<br />

their science education and careers.<br />

He was also instrumental in establishing the<br />

Joint Graduate School in Plant and Food Science<br />

with the University of Auckland, the first<br />

collaboration of its kind in New Zealand, and<br />

the Joint Graduate School of Horticulture and<br />

Food Enterprise with Massey University.<br />

On receiving the Thomson Medal, Dr Campbell<br />

said: “I am thrilled and humbled to receive<br />

this award. It is a credit to the many talented<br />

people I have been privileged to work with over<br />

Continued to page 3<br />

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NEW ZEALAND LABORATORY NEWS | NEW ZEALAND BIOSCIENCE<br />

ISSUE 116 | DECEMBER <strong>2016</strong><br />

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[ 2 ]


NEW ZEALAND LABORATORY NEWS | NEW ZEALAND BIOSCIENCE<br />

Reaching for the moon with NASA<br />

A Victoria University of Wellington<br />

PhD graduand is investigating what<br />

new information can be gained<br />

about moonquakes during his<br />

postdoctoral fellowship at NASA.<br />

Jesse-Lee Dimech, who is completing his<br />

PhD in Geophysics at Victoria, says seismic<br />

energy is useful for looking inside<br />

planets.<br />

“Using the energy from earthquakes, or<br />

in this case, moonquakes, we can gain insight<br />

into the composition and structure of<br />

the Moon.”<br />

Between 1969 and 1972, five of the Apollo<br />

missions successfully placed seismometers<br />

at landing sites on the Moon, which<br />

recorded ground motion and radioed this<br />

information back to Earth. Contained in this<br />

dataset are more than 13,000 moonquakes<br />

that were recorded up until 1977.<br />

“I’m working on categorising and detecting<br />

moonquakes using the Apollo seismic<br />

dataset, as well as some extra datasets not<br />

previously used for this purpose. This particular<br />

work is being done in collaboration<br />

with Dr Renee Weber, my advisor at NASA,<br />

and Dr Brigitte Knapmeyer-Endrun, a scientist<br />

at Germany’s Max Planck Institute for<br />

Solar System Research.<br />

“It's a great opportunity to work<br />

with some of the world's top planetary<br />

seismologists. By applying new seismic<br />

analysis techniques we may be able to learn<br />

new information about the Moon—even<br />

from such an old dataset,” says Mr Dimech.<br />

One of those new techniques is shear<br />

wave splitting analysis, a key research interest<br />

of Professor Martha Savage from Victoria’s<br />

School of Geography, Environment and<br />

Earth Sciences, who has collaborated with<br />

Mr Dimech to undertake the first shear wave<br />

splitting analysis off Earth.<br />

“When seismic waves travel through layers<br />

of rock they split in much the same way<br />

light does when it hits a crystal. By measuring<br />

how much splitting occurs, we can infer<br />

physical properties from the rock, such as<br />

stress and fracturing, the presence of fluids,<br />

and rock laminations,” says Mr Dimech.<br />

Another technique, developed by Victoria’s<br />

Associate Professors Richard Arnold and<br />

John Townend, is a statistical method of examining<br />

the geometry of the faults responsible<br />

for earthquakes.<br />

“I applied this technique in my PhD to<br />

Jesse-Lee Dimech<br />

earthquakes we found in the upper mantle—the<br />

layer beneath the crust—which<br />

was able to tell us what type of faults produced<br />

them. We will be using a modified<br />

version of this code to understand the type<br />

of faulting associated with ‘deep’ moonquakes,<br />

which are situated about halfway<br />

between the Moon’s surface and its core.<br />

“I’m continuing to work with Professor<br />

Savage and Associate Professor Arnold<br />

while I’m at NASA. New Zealand has some<br />

great scientific talent and I’m excited about<br />

maintaining these relationships and building<br />

new ones.”<br />

Some of the techniques Mr Dimech uses<br />

may also be useful in helping NASA learn<br />

about the composition of Mars when they<br />

land a seismometer there in two years’ time<br />

as part of the InSight mission to Mars.<br />

Australian-born Mr Dimech says he has<br />

loved space since he was a child, and a postdoctoral<br />

role at NASA is the culmination of a<br />

lifelong ambition.<br />

“I was actually pen pals with Australia’s<br />

first astronaut Andrew Thomas. We exchanged<br />

several letters when I was a kid,<br />

and I even talked to him on the phone once,<br />

as well as fellow astronaut John Glenn who<br />

just happened to be in the office at the time.<br />

They definitely inspired me. I was also the<br />

youngest member of an astronomy club.<br />

I’ve always been fascinated by NASA.”<br />

For more information contact Samantha<br />

Fisher, Communications Adviser, on 04-463<br />

5105 or samantha.fisher@vuw.ac.nz.<br />

ISSUE 116 | DECEMBER <strong>2016</strong><br />

Royal Society of New Zealand honours Dr Bruce Campbell<br />

From page 1<br />

the years.<br />

“I have focused my career on partnering<br />

science with users of new knowledge to enhance<br />

food, the environment and people. It is<br />

great to see this connectivity of science now<br />

PRODUCT NEWS<br />

gathering momentum to enrich our society<br />

and wellbeing.”<br />

Before his current role, Dr Campbell was<br />

general manager Science Operations at HortResearch,<br />

acting as interim CEO during the<br />

merger of HortResearch and Crop & Food Research<br />

in 2008 that formed Plant & Food Research.<br />

He began his career, after completing<br />

his PhD in the UK, as a scientist at DSIR Grasslands,<br />

then as Scientist and Science Leader at<br />

AgResearch.<br />

Dr Campbell received the Thomson Medal<br />

at the Royal Society Honours Dinner, held at<br />

the Transitional Cathedral in Christchurch.<br />

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[ 3 ]


NEW ZEALAND LABORATORY NEWS | NEW ZEALAND BIOSCIENCE<br />

ISSUE 116 | DECEMBER <strong>2016</strong><br />

Government commits another half-million<br />

dollars into SKA computing and software<br />

Government commits another halfmillion<br />

dollars into SKA computing<br />

and software<br />

[ 4 ]<br />

At the SKA site in South Africa, some of the SKA team in 2015, with Nicolas Erdody, Andrew Ensor (AUT) at left and Willem van<br />

Straten (AUT -sixth from the left), together with collaborators from Australia, Canada, South Africa and UK.<br />

Representatives of the AUT/Industry collaboration working on the SDP Computer System design, Andrew Ensor (Director HPC<br />

Research Lab AUT), TN Chan (Managing Director and System Architect Compucon NZ), Piers Harding (Senior Consultant Catalyst<br />

IT), Peter Baillie (Project Manager NZ SKA Alliance), Don Christie (Co-founder and Co-owner Catalyst IT), Nicolás Erdödy (Founder<br />

and CEO Open Parallel).<br />

The Square Kilometre Array will involve<br />

thousands of dishes across Australia<br />

and South Africa that will act as a giant<br />

radio telescope.<br />

The telescope, which will start partial<br />

operations in 2021 and have a lifetime of 50<br />

years, will help to create data images allowing<br />

scientists to see back to the early stages<br />

of the universe. https://www.youtube.com/<br />

watch?v=pOxohO7W4sk<br />

New Zealand is one of 10 countries with a<br />

key role in the project- with AUT and its High<br />

Performance Computing Research Lab leading<br />

the NZ SKA Alliance’s effort.<br />

The Ministry for Business, Innovation and<br />

Employment has contributed an additional<br />

488-thousand-dollars towards the research.<br />

That is on top of the previously invested<br />

$1.7M. That funding is targeting a collaboration<br />

between university researchers and NZ<br />

industry partners working on the computing<br />

aspects of the project – AUT, Catalyst IT,<br />

Compucon NZ, and Open Parallel.<br />

Together, they are helping to design the<br />

Science Data Processor for the SKA. It’s the<br />

Big Data supercomputer system that will<br />

have the processing power of 100 million<br />

computers. That’s because the telescope will<br />

be producing data equivalent to 100 times<br />

the global internet traffic.<br />

The collaboration is working on cuttingedge<br />

computer nodes, algorithms and software<br />

to ensure the supercomputer will keep<br />

up with the unprecedented data rates.<br />

The world doesn’t have computers capable<br />

of processing this extraordinary level<br />

of data yet, so AUT High Performance Computing<br />

Lab is using AUT’s radio telescopes<br />

at Warkworth for modelling the SKA’s demands.<br />

Dr Andrew Ensor is the head of AUT’s HPC<br />

Lab and the director of the NZ SKA Alliance.<br />

“The SKA represents numerous firsts for<br />

New Zealand, being the biggest Big Data<br />

project in the world, the largest Science project<br />

NZ has ever lead substantial parts of, one<br />

of the largest NZ involvements in an international<br />

ICT collaboration, and what is becoming<br />

the longest term NZ academic-industry<br />

project collaboration.”<br />

Pro Vice Chancellor of Research and Innovation<br />

at AUT, Professor John Raine, says it’s<br />

great to see the government continuing to<br />

invest in the project.<br />

“NZ’s work on the SKA project is creating<br />

lasting research relationships in New Zealand<br />

and abroad and creating jobs and intellectual<br />

property that will outlive the SKA.”<br />

A director at Catalyst IT, Don Christie, is<br />

delighted Catalyst IT is now able to get more<br />

involved<br />

"Catalyst IT is now able to get more involved<br />

in the project, bringing valuable<br />

OpenStack cloud expertise as Australasia’s<br />

largest open source software company."<br />

Compucon’s Managing Director TN Chan<br />

says they’ve been working on the SKA since<br />

2013.<br />

“Compucon New Zealand has always<br />

been taking a role in computing node architecture<br />

investigations. We will stay in this<br />

area and at the same time develop an industry<br />

level ecosystem in New Zealand which<br />

did not exist before. “<br />

Nicolás Erdödy the CEO of Open Parallel,<br />

which is based in Oamaru, says they’ve had<br />

up to a dozen people working on the SKA<br />

computing work for the past six years.<br />

“This new funding will allow Open Parallel<br />

to employ new staff in Otago, increase its<br />

global collaboration already in place with<br />

top universities in New Zealand and overseas,<br />

boost our partnership with multinationals<br />

towards the SKA construction tender<br />

of 2018 and continue our R&D on applications<br />

of our work in the SKA compute platforms<br />

for NZ primary industries.”


NEW ZEALAND LABORATORY NEWS | NEW ZEALAND BIOSCIENCE<br />

Victoria research flourishes in Marsden funding<br />

Victoria University of Wellington<br />

researchers have received 26<br />

prestigious Marsden Fund grants<br />

worth $14.3 million, the largest<br />

number ever received by the<br />

University and more than 22 percent<br />

of the total funding awarded in <strong>2016</strong>.<br />

The Marsden Fund supports research<br />

excellence, allowing New Zealand’s<br />

most talented researchers to explore<br />

ideas at the forefront of their disciplines.<br />

The Fund is administered by the Royal Society<br />

of New Zealand on behalf of the Government.<br />

Victoria University researchers received<br />

22.2 percent of total Marsden grants, securing<br />

26 out of the 117 research projects<br />

funded nationwide.<br />

Victoria projects awarded funding<br />

range from research into nanoparticles,<br />

glaciers and election turnouts to gender,<br />

Māori traditional calendars and the cosmic<br />

web.<br />

Of the 26 successful Victoria researchers,<br />

16 are in the Faculty of Science, and six<br />

of those are in the School of Chemical and<br />

Physical Sciences.<br />

Four grants were awarded to researchers<br />

in the humanities, three to engineering<br />

staff, two for education research, and one<br />

to staff in the Faculty of Law.<br />

The funding consists of 17 Standard<br />

grants for established researchers and<br />

nine Fast-Start grants for researchers early<br />

in their careers.<br />

Of particular note is the $565,000<br />

awarded to Professor Rod Downey for a<br />

project titled ‘The mathematics of computation’.<br />

This is Professor Downey’s ninth<br />

Marsden grant as a Principal Investigator,<br />

putting him among an elite group of researchers<br />

to consistently win funding over<br />

many years.<br />

Vice-Provost (Research) Professor Kate<br />

McGrath says the results are excellent and<br />

confirm the strength of research capability<br />

at Victoria.<br />

“These successful projects reflect the<br />

world-leading and potentially gamechanging<br />

research being carried out at<br />

Victoria.<br />

“A particular highlight is Victoria’s growing<br />

reputation as a leader in the physical<br />

and chemical sciences, with staff in this<br />

area awarded Marsden funding of just under<br />

$4.5 million. In addition, the two grants<br />

awarded to researchers from the Faculty of<br />

Education is notable and an outstanding<br />

achievement.<br />

“As a global-civic capital city university,<br />

we want to lead thinking on major societal,<br />

economic and environmental issues.<br />

This success gives us assurance that our<br />

research is of the highest calibre.”<br />

Victoria University recipients of Marsden<br />

Grants (with funds to be distributed<br />

over three years) are:<br />

Standard grants:<br />

• Dr Shen Vun Chong (Robinson Research<br />

Institute): Nanostructuring in iron-based<br />

wires for ultra-high current density,<br />

$720,000<br />

• Dr Joel Colon-Rios (Law): Constituent<br />

power and the law, $420,000<br />

• Professor Carmen Dalli (Education): War<br />

and peace in the nursery: How do young<br />

children negotiate conflict to establish<br />

belonging and wellbeing in a multi-ethnic<br />

New Zealand early childhood centre,<br />

$735,000<br />

• Professor Simon Davy (Biological Sciences):<br />

From parasitism to mutualism: Symbiosis<br />

interaction states and the adaptability<br />

of reef corals to climate change,<br />

$830,000<br />

• Professor Rod Downey (Mathematics and<br />

Statistics): The mathematics of computation,<br />

$565,000<br />

• Dr Pauline Harris (Chemical and Physical<br />

Sciences): Ngā Takahuringā ō te ao: The<br />

Continued on page 6<br />

ISSUE 116 | DECEMBER <strong>2016</strong><br />

Instrumentation & Measurement for the food industry<br />

Inline Process<br />

Liquid Analysis:<br />

Water:<br />

Wasterwater:<br />

Concentration, clarity, colour, moisture content<br />

FAC, ClO 2<br />

, Ozone, pH, TDS, NO 3<br />

, Turbidity<br />

pH, DO, NO 3<br />

, NH 4<br />

, PO , Suspended Solids,<br />

4<br />

Flow & Level, Data Transmission<br />

Gas Analysis: Measurement & Alarm - example O 2<br />

& CO 2<br />

Offline <strong>Laboratory</strong>/QA<br />

+64 9 525 1875 | info@belltechnology.co.nz | belltechnology.co.nz<br />

pH & Temperature, RH, Datalogging / QA – Fixed Systems (warehousing<br />

& coolstores) hard-wired or RF options, Transportation & In-situ Food<br />

Pasteurisation Process Validation, NIR Analysers, Refractometers & Density,<br />

Viscosity & Autotitrators, plus General <strong>Laboratory</strong> Hardware.<br />

[ 5 ]


NEW ZEALAND LABORATORY NEWS | NEW ZEALAND BIOSCIENCE<br />

ISSUE 116 | DECEMBER <strong>2016</strong><br />

Nelson Marlborough Health follows suit<br />

with RACS Respect Agreement<br />

A Memorandum of Understanding<br />

(MoU) aimed at building respect<br />

and improving patient safety in<br />

surgery has been signed between<br />

the Royal Australasian College<br />

of Surgeons (RACS) and Nelson<br />

Marlborough Health (NMH).<br />

The MoU, a collaboration formed<br />

under the RACS 2015 Action Plan:<br />

Building Respect, Improving Patient<br />

Safety, commits both organisations to<br />

a shared vision to provide high quality<br />

training, education and experience in the<br />

practice of surgery and is the second to<br />

be signed in New Zealand, following an<br />

agreement struck with the University of<br />

Otago last month.<br />

RACS and NMH will work together to<br />

ensure that surgical supervisors have the<br />

necessary skills and attributes and are<br />

supported to provide training, assessment,<br />

feedback and support to Trainees<br />

and International Medical Graduates free<br />

of discrimination, bullying and sexual harassment.<br />

RACS vice-president Professor Spencer<br />

Beasley said the College strongly supported<br />

NMH’s efforts.<br />

“RACS and NMH strongly support the<br />

rights of all healthcare professionals to<br />

a safe training and work environment<br />

where they can realise their full potential,”<br />

he said.<br />

"We know that if we can improve the<br />

culture of medicine, and surgery in particular,<br />

we can expect better patient outcomes.<br />

This is a powerful reason why we<br />

wish to work together with this initiative."<br />

Acting NMH CEO Peter Bramley says<br />

that the agreement will strengthen Nelson<br />

Marlborough Health’s initiatives to<br />

improve patient safety and its overall<br />

workplace culture.<br />

“Under the agreement, we will further<br />

develop programs and processes to address<br />

inappropriate staff behaviour across<br />

our hospitals, as well as aligning existing<br />

policies and processes to deal with these<br />

concerns,” Mr Bramley said.<br />

Specific initiatives include:<br />

• Sharing relevant information and resources<br />

regarding the education and<br />

training available with the respective<br />

institutions.<br />

• Exploring models for less than full-time<br />

training for surgical trainees and to promote<br />

these to allow greater flexibility<br />

and fulfilment of family commitments .<br />

Victoria research flourishes in Marsden funding<br />

From page 5<br />

effect of climate change on traditional<br />

Māori calendars, $720,000<br />

• Dr Justin Hodgkiss (Chemical and Physical<br />

Sciences): The origin of UV photoprotection<br />

in the brown skin pigment eumelanin,<br />

$870,000<br />

• Associate Professor Melanie Johnston-<br />

Hollitt (Chemical and Physical Sciences):<br />

Mapping the cosmic web with the Murchison<br />

Widefield Array, $870,000<br />

• Professor Estate Khmaladze (Mathematics<br />

and Statistics): On the theory of distribution-free<br />

tests for statistical hypothesis<br />

and unitary operators in functional spaces,<br />

$585,000<br />

• Professor Bastiaan Kleijn (Engineering and<br />

Computer Science): Distributed processing<br />

with information privacy in sensor<br />

networks, $790,000<br />

• Professor Eric Le Ru (Chemical and Physical<br />

Sciences): Probing the optical absorption<br />

of molecules adsorbed on metallic<br />

nanoparticles, $840,000<br />

• Associate Professor Ivy Liu (Mathematics<br />

and Statistics): Dimension reduction for<br />

mixed type multivariate data, $550,000<br />

• Dr Peter Ritchie (Biological Sciences): Testing<br />

for fishing-induced evolution using<br />

DNA from ancient and modern snapper,<br />

$830,000<br />

• Dr Sarah Ross (English, Film, Theatre and<br />

Media Studies): ‘Woe is me': Women and<br />

complaint in the English Renaissance,<br />

[ 6 ]<br />

$450,000<br />

• Associate Professor Jeff Sissons (Social<br />

and Cultural Studies): The mysterious disappearance<br />

of tuuaahu, $390,000<br />

• Dr Mattie Timmer (Chemical and Physical<br />

Sciences): The missing link: A traceless<br />

linking strategy for the conjugation of<br />

complex carbohydrates to proteins and<br />

peptides, $870,000<br />

• Professor Jack Vowles (History, Philosophy,<br />

Political Science and International Relations):<br />

A 'Big Data' approach to the problem<br />

of electoral turnout, $635,000<br />

Fast-Start grants:<br />

• Dr Shaun Eaves (Antarctic Research Centre):<br />

Establishing natural baselines of glacier<br />

variability in a warm world, $300,000<br />

• Dr Lorena Gibson (Social and Cultural<br />

Studies): East side orchestras: Music, poverty,<br />

and social change,<br />

$300,000<br />

• Dr Alia Martin (Psychology):<br />

Children's understanding<br />

of shared<br />

knowledge and its<br />

importance for effective<br />

communication,<br />

$300,000<br />

• Dr Yi Mei (Engineering<br />

and Computer Science):<br />

Automatic design of<br />

heuristics for dynamic<br />

arc routing problem with<br />

genetic programming,<br />

$300,000<br />

• Dr Polly Stupples (Geography, Environment<br />

and Earth Sciences): Stretching the<br />

celluloid ceiling: Women's creative agency<br />

in the emergent Pacific film industry,<br />

$300,000<br />

• Dr Tirta Susilo (Psychology): Fractionating<br />

face blindness: Creating a taxonomy for<br />

developmental prosopagnosia, $300,000<br />

• Dr Bronwyn Wood (Education): Citizenship<br />

in Aotearoa New Zealand: Young people,<br />

belonging and changing times, $300,000<br />

• Dr Bing Xue (Engineering and Computer<br />

Science): Large-scale evolutionary feature<br />

selection for classification, $300,000<br />

• Dr Cathie Zheng (Chemical and Physical<br />

Sciences): Finding the needle by removing<br />

the haystack: Modeling diffuse foregrounds<br />

to detect the epoch of reionization,<br />

$300,000.<br />

laboratorynews<br />

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Waikato Business Publications<br />

PO Box 1425, Hamilton, New Zealand<br />

Ph (07) 838 1333 | Fax (07) 838 2807 | Email: labnews@wbn.co.nz<br />

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Please submit editorial contributions to: mike.blake@wbn.co.nz<br />

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NEW ZEALAND LABORATORY NEWS | NEW ZEALAND BIOSCIENCE<br />

Unique NZ synthetic chemistry<br />

scientist wins award<br />

The importance of fundamental<br />

science to expand new discoveries.<br />

Imagine a time before electronics, synthetic<br />

clothing, tyres, contact lenses or<br />

plastic products such as money, packaging<br />

and toys existed. This wide variety of<br />

man-made products has revolutionised our<br />

lives. But, what other materials are scientists<br />

capable of creating?<br />

That’s what Dr Erin Leitao, a chemical scientist<br />

from the University of Auckland won her<br />

award for, and her prize money will go into accelerating<br />

these yet to be seen materials.<br />

Dr Leitao is the <strong>2016</strong> New Zealand Fellow<br />

of the L’Oréal-UNESCO For Women in Science<br />

programme*, receiving a $25,000 grant to assist<br />

her independent research at the University<br />

of Auckland.<br />

For 18 years, the L’Oréal-UNESCO For<br />

Women in Science programme has supported<br />

women researchers around the world with<br />

the objective of recognising and rewarding<br />

their accomplishments whilst encouraging<br />

young women to enter the profession.<br />

“We are delighted to continue our support<br />

for a programme that recognises and<br />

rewards women for scientific excellence and<br />

for their contribution to society,” says Martin<br />

Smith Executive General Manager, L’Oréal<br />

New Zealand.<br />

“Research and innovation is at the heart<br />

of our business, so we are immensely proud<br />

to provide the opportunity to ensure that<br />

women are fairly represented at all levels in<br />

science.<br />

“Erin’s research is fundamental and time<br />

consuming so it is essential that we play<br />

our role to support new research solutions<br />

to help solve the world’s most complex<br />

questions.<br />

“It gives us great pleasure to present her<br />

with the L'Oréal-UNESCO For Women in Science<br />

New Zealand Fellowship for <strong>2016</strong>.”<br />

Dr Leitao is the only scientist in New Zealand<br />

working towards creating new polymeric<br />

materials with main-group elements<br />

comprising the backbone. The vast majority<br />

of synthetic chemistry is targeted at making<br />

molecules and materials containing predominantly<br />

carbon atoms.<br />

Dr Leitao wants to create new polymers<br />

by making use of main-group (inorganic) elements<br />

such as silicon, phosphorus, nitrogen,<br />

and oxygen. These alternatives to carbon are<br />

not only in high abundance, they give the<br />

potential to produce materials with unexplored<br />

properties and reactivity.<br />

Dr Leitao is investigating ways of creating<br />

new polymer building blocks and new ways<br />

in which to connect them.<br />

Dr Leitao says the materials resulting<br />

from the creation of synthetic polymers with<br />

main-group elements will give rise to new<br />

applications and a better understanding of<br />

the behaviour of the various main-group<br />

molecules and polymers.<br />

“It’s an under-explored area of science so<br />

there is potential to make significant discoveries.<br />

And that has the exciting prospect of<br />

one day putting New Zealand on the global<br />

map as a key player in main-group polymer<br />

chemistry, especially when it comes to commercializing<br />

new materials as there is a lot of<br />

support for that here,” she says.<br />

“The L’Oréal FWIS fellowship will help kickstart<br />

my independent research career as well<br />

as provide financial support which will make<br />

balancing a family and a career more effective.<br />

“Funding for basic science is crucial as we<br />

need it for new discoveries that enable new<br />

applications which haven't even been considered<br />

yet.<br />

“It is vital work and without it we could<br />

miss out on knowledge that will expand our<br />

understanding of science,” Dr Leitao says.<br />

“Currently we are working towards creating<br />

stable silicon based polymers which can conduct<br />

electricity that may be found in applications<br />

such as sensors or in electronic devices.”<br />

Canadian-born, Dr Leitao is a researcher<br />

and lecturer at the University of Auckland<br />

working in the School of Chemical Sciences<br />

on catalysis in inorganic and main group<br />

chemistry.<br />

Award winner: Dr Erin Leitao<br />

ISSUE 116 | DECEMBER <strong>2016</strong><br />

Guild congratulates Kiwi winners of Australia’s<br />

National Student Business Plan Competition<br />

The Pharmacy Guild of New Zealand<br />

congratulated the team from the University<br />

of Auckland which won the<br />

Pharmacy Guild of Australia’s National Student<br />

Business Plan Competition.<br />

The winning team of Akhila Puthigae,<br />

Surbhi Patel, Philip Cabasag and Sean Turner<br />

won with their fictitious NaturEd Pharmacy.<br />

NaturEd Pharmacy is based in Rotorua, and<br />

features a multilingual EduCare programme<br />

which revolutionises health literacy and patient<br />

education.<br />

The team was declared the competition<br />

winners at the recent <strong>2016</strong> Pharmacy Connect<br />

conference in Sydney. The two runners-<br />

up were Eye Scream for Eye Screens from<br />

the University of Technology Sydney, and<br />

One Life Pharmacy from the University of<br />

Sydney.<br />

The three finalists, from a total of 16 entries,<br />

successfully progressed through the<br />

business plan, quarter-final and semi-final<br />

rounds.<br />

They had to complete financial quizzes,<br />

write short answer essays about business<br />

finance and operations, and pitch their<br />

business ideas to the judges before being<br />

selected to pitch to the Pharmacy Connect<br />

conference delegates.<br />

Following the live pitches, each team<br />

met with the judging panel to answer some<br />

post-pitch questions about their business.<br />

The National Student Business Plan<br />

Competition is an initiative of the Pharmacy<br />

Guild of Australia designed to promote creative<br />

entrepreneurship among pharmacy<br />

students and encourage the development<br />

of viable, innovative, pharmacist-owned<br />

community pharmacies.<br />

The competition is open to all pharmacy<br />

schools across Australia and New Zealand<br />

and provides $15,000 in cash prizes to the<br />

finalists, a portion of which goes directly to<br />

the participating schools of pharmacy who<br />

produce the top three teams each year.<br />

[ 7 ]


NEW ZEALAND LABORATORY NEWS | NEW ZEALAND BIOSCIENCE<br />

ISSUE 116 | DECEMBER <strong>2016</strong><br />

Conductivity measurement is the<br />

easiest means of determining that<br />

the water purification system has<br />

produced water devoid of dissolved salts.<br />

Conductivity is a measure of water’s capability<br />

to pass electrical flow. Traditionally<br />

the measurement was as Resistivity, the water’s<br />

opposition to the flow of a current over<br />

distance. Both properties directly related<br />

to the concentration of ions in the water.<br />

These conductive ions typically come from<br />

dissolved salts and inorganic materials such<br />

as alkalis, Chlorides, Sulfides and Carbonate<br />

compounds.<br />

Conductivity is usually measured in micro-<br />

or milliSiemens per centimeter (uS/cm<br />

or mS/cm).<br />

Formally it is defined as the reciprocal of<br />

Resistivity, with Pure water having a resistance<br />

of 18.2 Mohm/cm. By nature resistivity<br />

and conductivity are reciprocals (1/measurement).<br />

The units name Mho and Ohm<br />

are the same letters, in reverse.<br />

A competent laboratory’s pure water QA<br />

program must include having a conductivity<br />

meter on hand. However the laboratory<br />

is faced with two problems.<br />

Firstly, most conductivity meters are<br />

PRODUCT NEWS<br />

Verifying the Quality of <strong>Laboratory</strong><br />

Deionised / Distilled Water<br />

made to work over a wide<br />

range, from tap water up to<br />

brackish waters. With such a<br />

wide range this will stretch the<br />

instrument’s measuring ability.<br />

This is because without having<br />

the ability to select a more precise<br />

measurement cell having<br />

the range specific cell constant<br />

(basically a function of the cell’s<br />

electrode geometry), the readings<br />

will not be made to the instrument<br />

system’s optimum ability.<br />

The second problem the laboratory<br />

faces is the requirement for<br />

traceable calibration performed<br />

against a low value reference of 5uS/<br />

cm or less.<br />

Bell Technology now provides a<br />

solution to both these issues by offering<br />

a low cost conductivity dip-meter,<br />

Jenco’s newly released EC331 model<br />

(resolution 0.1uS/cm), with measuring cell<br />

specific for low conductivity (high resistance),<br />

that is to say of low Cell Constant.<br />

Perfect for pure water. We also provide a<br />

calibration service for the instrument using<br />

a traceable reference solution of 5 uS/<br />

cm and will offer this as an ongoing service<br />

through our calibration laboratory.<br />

For more information contact us via email<br />

info@belltechnology.co.nz<br />

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• Camera powered from the microscope, saving<br />

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• Personal smartphones or tablets in class to<br />

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In association with the NZ Microbiological Society Inc.<br />

Vol. 25 No. 6 • <strong>December</strong> <strong>2016</strong><br />

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LN_BioSci_1216_FC_MD_Quickdrop_trsfr.indd 1<br />

29/11/<strong>2016</strong> 1:49:41 p.m.


NEW ZEALAND LABORATORY NEWS | NEW ZEALAND BIOSCIENCE<br />

VOL. 25 NO. 6 | DECEMBER <strong>2016</strong><br />

New: 4 liter<br />

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[ 2 ]<br />

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Eppendorf® and the Eppendorf logo are registered trademarks of Eppendorf AG, Germany. U.S. Design Patents are listed on www.eppendorf.com/ip<br />

All rights reserved, including graphics and images. Copyright © <strong>2016</strong> by Eppendorf AG.<br />

Watch video!


NEW ZEALAND LABORATORY NEWS | NEW ZEALAND BIOSCIENCE<br />

Small and extremely resilient<br />

– the secrets of black fungi<br />

Highly resistant to stresses, black<br />

fungi are real champions among<br />

microorganisms. With the support<br />

of the Austrian Science Fund FWF, a<br />

research team in Vienna discovered<br />

that the fungi owe their qualities<br />

to hitherto unknown proteins and<br />

special processes at cellular level.<br />

They are true survival artists, not minding<br />

the cold any more than they do<br />

heat.<br />

Whether their environment offers little or<br />

plentiful oxygen, is wet, salty, dry or has contaminated<br />

soils – the black fungi keep their<br />

cool and feel at home in even the most inhospitable<br />

of living conditions.<br />

How do they do that?<br />

"To our great surprise, the fungi show<br />

almost no stress response at all. This means<br />

something in their structure makes them<br />

inherently resistant to stress," relates Katja<br />

Sterflinger.<br />

With the support of the Austrian Science<br />

Fund FWF, the microbiologist used a climate<br />

chamber to simulate different stress situations<br />

as the fungi encounter them in climatically<br />

extreme regions such as the Arctic or<br />

deserts. She first observed how the cells of<br />

the fungi, or, more precisely, its proteins, react<br />

to cold, heat, ozone or aridity.<br />

UNIQUE "PROTEIN TOOL"<br />

Katja Sterflinger heads the "Extremophile<br />

Center" at the Vienna Institute of BioTechnology<br />

(VIBT), University of Natural Resources<br />

and Life Science.<br />

The climate chambers, built specifically<br />

for the Institute, and the use of cutting-edge<br />

sequencing technologies have made it possible<br />

for the first time to identify the proteins<br />

of black fungi.<br />

"This was very difficult, because they are<br />

not like or even comparable to anything else<br />

we have seen so far," notes Sterflinger.<br />

The researchers have now learned that<br />

the "microcolonial fungi", as the technical<br />

term goes, have a unique protein system that<br />

enables them to grow both at 0° C or at 45° C.<br />

The microbes even survived a simulated<br />

trip to Mars. All it takes them to achieve that<br />

is some minor molecular adjustment.<br />

"Depending on whether it is hot or cold,<br />

the fungi will change a little. But that is just<br />

fine-tuning,” said Sterflinger.<br />

This is actually a very smart move on<br />

the part of the fungi, because any dramatic<br />

changes would consume energy.<br />

The fungi have no need for that and there-<br />

fore remain active even in low-nutrient environments<br />

such as glaciers or stone.<br />

UNDERSTANDING CELLULAR PROCESSES<br />

In a next step, the team headed by Sterflinger<br />

matched the protein data yield with<br />

the transcriptome data, i.e. they analysed the<br />

sequence of cellular processes.<br />

The researchers discovered that the cellular<br />

secret seems to be less related to the<br />

proteins than to the non-coding RNA (ribonucleic<br />

acid).<br />

These molecules are active in the cell<br />

without being translated into proteins.<br />

While their biological functions had been<br />

largely undetermined until recently, it is now<br />

known that they have an important role in<br />

regulating a variety of cellular processes.<br />

After all, only two percent of the genetic<br />

material that is actively read is translated into<br />

proteins.<br />

THE EXCEPTIONAL TALENT OF<br />

"EXOPHIALA DERMATITIDIS"<br />

Among the hundreds of fungal strains the<br />

Viennese researchers have investigated to<br />

date, "Exophiala dermatitidis" has turned out<br />

to be a particularly versatile extremophile.<br />

This microfungus, also known as 'black<br />

yeast', is found across all temperature ranges<br />

from cold to warm and withstands simply everything.<br />

"It grows on glaciers just as in saunas, and,<br />

unfortunately, also in our dishwashers. And it<br />

has the disagreeable property of being a human<br />

pathogen", explains Katja Sterflinger.<br />

This is the negative side of the fungus.<br />

On the plus side, it has an optimal talent<br />

for degrading hydrocarbons, i.e. toxins.<br />

This latter quality induced the microbiologists<br />

from the "Extremophile Center"<br />

to launch a second FWF-funded project in<br />

which they screened more than 200 black<br />

yeasts in their search for a biological "cleaner"<br />

for exhaust fumes and contaminated soils.<br />

Apart from "Exophiala" they found only<br />

one more fungus with the ability to degrade<br />

environmental toxins.<br />

Unfortunately, this second variety is also<br />

closely related to human pathogen strains,<br />

which meant that plans for using them as<br />

biofilters have been shelved for the time being.<br />

MEDICAL FOCUS<br />

Instead, the experts from Vienna's University<br />

of Natural Resources and Life Science<br />

now focus on medical issues and have set out<br />

to investigate the molecules of the pathogenic<br />

"Exophiala dermatitidis" more closely,<br />

since the fungus not only provokes infections<br />

in people with weak immune systems,<br />

but also increasingly in individuals of average<br />

good health, as Sterflinger notes, underlining<br />

the relevance of her research for medical science.<br />

According to the microbiologist, the extreme<br />

stress tolerance of the fungus is probably<br />

related to its pathogenicity.<br />

"This is an area we still don't know enough<br />

about. It is our goal to find out more about<br />

the virulence factors of the fungus."<br />

Personal details<br />

Katja Sterflinger is the head of the Extremophile<br />

Center (http://www.extremophilecenter.at)<br />

at the Vienna Institute of BioTechnology<br />

(VIBT), University of Natural Resources<br />

and Life Science. The microbiologist specialises<br />

in the study of fungi and black yeasts<br />

and as such is a sought-after expert when it<br />

comes, for instance, to the preservation of<br />

monuments.<br />

Scientific Contact:<br />

Assoc. Prof. Dr. Katja Sterflinger<br />

Institute of Biotechnology<br />

University of Natural Resources and Life Sciences<br />

Vienna Muthgasse 18, 1190 Vienna T<br />

+43 / 1 / 47654-79862 E katja.sterflinger@<br />

boku.ac.at W http://www.boku.ac.at/en/<br />

Publications<br />

Blasi, B; Poyntner, C; Rudavsky, T; Prenafeta-<br />

Boldú, FX; Hoog, S; Tafer, H; Sterflinger, K:<br />

Pathogenic Yet Environmentally Friendly?<br />

Black Fungal Candidates for Bioremediation<br />

of Pollutants, in: Geomicrobiology<br />

Journal <strong>2016</strong>; 33(3-4):308-317, doi:<br />

10.1080/01490451.2015.1052118 http://<br />

www.tandfonline.com/doi/full/10.1080/014<br />

90451.2015.1052118?scroll=top&needAcces<br />

s=true<br />

Blasi, B; Tafer, H; Tesei, D; Sterflinger, K: From<br />

Glacier to Sauna: RNA-Seq of the Human<br />

Pathogen Black Fungus Exophiala dermatitidis<br />

under Varying Temperature Conditions<br />

Exhibits Common and Novel Fungal Response,<br />

in: PLoS One. 2015; 10(6):e0127103,<br />

doi: 10.1371/journal.pone.0127103<br />

http://journals.plos.org/plosone/<br />

article?id=10.1371/journal.pone.0127103<br />

Tesei, D; Marzban, G; Marchetti-Deschmann,<br />

M; Tafer, H; Arcalis, E; Sterflinger, K: Proteome<br />

of tolerance fine-tuning in the human pathogen<br />

black yeast Exophiala dermatitidis, in:<br />

Journal of Proteomics. 2015; 128:39-57, doi:<br />

10.1016/j.jprot.2015.07.007<br />

https://www.ncbi.nlm.nih.gov/<br />

pubmed/26189359<br />

Zakharova, K; Tesei, D; Marzban, G; Dijksterhuis,<br />

J; Wyatt, T; Sterflinger, K: Microcolonial<br />

fungi on rocks: a life in constant drought?, in:<br />

Mycopathologia. 2013; 175(5-6):537-547, doi:<br />

10.1007/s11046-012-9592-1<br />

https://www.ncbi.nlm.nih.gov/<br />

pubmed/23073825<br />

[ 3 ]<br />

VOL. 25 NO. 6 | DECEMBER <strong>2016</strong>


NEW ZEALAND LABORATORY NEWS | NEW ZEALAND BIOSCIENCE<br />

VOL. 25 NO. 6 | DECEMBER <strong>2016</strong><br />

Bioelectronic therapy effective for patients<br />

with medically unexplained symptoms<br />

An observational study presented<br />

at the at the International Society<br />

for Pharmacoeconomics and<br />

Outcomes Research (ISPOR) 19th<br />

Annual European Congress has<br />

found that non-invasive vagus<br />

nerve stimulation is an effective<br />

treatment for patients with<br />

medically unexplained symptoms.<br />

The study also showed that nVNS treatment<br />

significantly reduced the total<br />

number of GP appointments and hospital<br />

referrals required by these patients. A<br />

second poster presented by the York Health<br />

Economics Consortium (YHEC), supported by<br />

a grant from the Yorkshire and Humber Academic<br />

Health Science Network, calculated<br />

the study was cost-effective.<br />

The research has found that up to 66<br />

percent of patients who suffer from at least<br />

three of the following conditions, primary<br />

[ 4 ]<br />

headache, gastric motility disorders, anxiety,<br />

depression, and widespread chronic pain,<br />

experienced an improvement in their overall<br />

health following a medication review and<br />

after they started nVNS treatment with electroCore’s<br />

gammaCore device. Sixty percent<br />

of adult primary headache patients have one<br />

or more other medically unexplained symptoms<br />

[1] .<br />

Approximately 25 percent of all GP consultations,<br />

and 25 percent of all hospital referrals,<br />

are generated by 10 percent of the<br />

18 to 70-year-old UK patient population who<br />

suffer from multiple medically unexplained<br />

symptoms. As a result of the study there was<br />

a 19 percent reduction in the number of GP<br />

appointments attended by the patients, and<br />

a 23 percent reduction in their number of<br />

hospital referrals.<br />

This study comes in the light of recently<br />

published NICE guidelines describing the<br />

need to optimise the care received by patients<br />

with multimorbidity.<br />

NICE chairman Professor David Haslam<br />

Themis Bioscience successfully closes<br />

10 million euro financing round<br />

The fresh capital will be used to complete<br />

a phase 2 clinical trial of its lead<br />

product, a vaccine candidate against<br />

Chikungunya fever.<br />

Further products that will benefit include<br />

the company's Zika virus vaccine<br />

whose development just recently received<br />

significant financial support by Innovate<br />

UK.<br />

Dr Erich Tauber, CEO and co-founder of<br />

Themis, on the successful completion of<br />

the company's second financing round:<br />

"We are delighted about the continuous<br />

trust of our existing investors and of Austria's<br />

leading Venture Fund aws Gruenderfonds.<br />

“This trust and our recent excellent<br />

product development and technology<br />

progress have also attracted new investors<br />

and we are very grateful for their support."<br />

The now successfully closed investment<br />

round included the existing investors Ventech,<br />

Omnes Capital and Wellington Partners<br />

with the latter leading the round. New<br />

investors were undisclosed business angels<br />

with a focus on vaccine development and<br />

the aws Gruenderfonds.<br />

Dr Regina Hodits, general partner at the<br />

lead investor Wellington Partners, comments<br />

on their investment decision: "Themis'<br />

focus on prophylactic vaccines for<br />

emerging tropical infectious diseases, its<br />

patented platform technology and the recent<br />

very encouraging results from a phase<br />

1 clinical trial of its lead candidate make the<br />

company a very attractive investment opportunity.<br />

“We want the company's vaccine portfolio<br />

to develop at a fast pace and are willing<br />

and determined to support Themis on its<br />

growth path."<br />

At the heart of Themis' success lies the<br />

company's proprietary Themaxyn® platform.<br />

It uses a standard measles virus<br />

vaccine as a vector, developed at Institut<br />

Pasteur in Paris, and constitutes the basis<br />

of the company's pipeline. As measles vaccines<br />

have been successfully used in hundreds<br />

of millions of people globally, the<br />

Themaxyn® platform offers an excellent<br />

safety profile and clear advantages in terms<br />

of a validated, low-cost production process.<br />

Recent phase 1 clinical trial results of the<br />

company's lead product, a Chikungunya<br />

vaccine, proved the suitability of the vector<br />

for other indications and the observed<br />

immune responses encouraged the management<br />

to move this vaccine candidate<br />

rapidly to a phase 2 trial, which has been<br />

initiated earlier this year.<br />

Continued on page 5<br />

commented: “Actually now many patients<br />

have multiple problems. People don’t die but<br />

live with multiple diseases. Now we need to<br />

build care around these people - and the vital<br />

increasing role of the generalist comes along<br />

with this.” [2]<br />

The study was carried out in seven primary<br />

care practices across the UK by expert<br />

pharmacists from Interface Clinical Services.<br />

A total of 233 patients, who used the gammaCore<br />

nVNS device alongside their existing<br />

treatments, were assessed after periods of<br />

eight weeks and 40 weeks using the EQ-5D-<br />

5L quality of life index. Patients reported less<br />

pain and discomfort, and improved ability to<br />

perform their normal daily activities, as well<br />

as lower levels of anxiety and depression.<br />

Patients were asked to self-administer<br />

three nVNS doses per day, with each dose<br />

equalling two minutes of electrical stimulation<br />

to the vagus nerve. Interface pharmacists<br />

provided training to patients on how<br />

to use the gammaCore device. The patients<br />

found the therapy very easy to use at home,<br />

and reported no serious side effects.<br />

Dr. James Ward, GP and GPwSI in Headache<br />

at Oaklands Health Centre, West Yorkshire,<br />

said: “We introduced this service into<br />

practice in 2014 and as a result have improved<br />

the way we manage patients with complex<br />

medically unexplained symptom multimorbidity.<br />

Whilst the patients are benefiting from<br />

having a better quality of life, we as GPs benefit<br />

from knowing that patients feel empowered<br />

to better manage their health at home.”<br />

About electroCore<br />

ElectroCore LLC, the New Jersey based<br />

bioelectric pharma company, is focused on<br />

developing non-invasive vagus nerve stimulation<br />

therapies (the gammaCore device)<br />

for the treatment of multiple conditions in<br />

neurology, psychiatry, gastroenterology, and<br />

respiratory fields. The company’s initial target<br />

is the treatment of primary headaches<br />

(migraine and cluster headache), and the<br />

associated chronic co-morbidities of gastric<br />

motility, psychiatric, sleep, and pain disorders<br />

that drive disproportionately large direct and<br />

indirect costs within the healthcare system<br />

and society.<br />

GammaCore is available in the UK. In Germany<br />

gammaCore is distributed by Desitin.<br />

In the USA electroCore is awaiting FDA approval.<br />

[1] http://www.ecorelibrary.com/landing/<br />

pdf/GNS_001558_Poster_26Sept<strong>2016</strong>_FI-<br />

NAL.pdf<br />

[2] http://www.gponline.com/nhs-redesigncare-around-multimorbidity-nice-experts-warn/article/1411511


NEW ZEALAND LABORATORY NEWS | NEW ZEALAND BIOSCIENCE<br />

Themis Bioscience successfully<br />

closes 10 million euro financing round<br />

From page 4<br />

This progress not only pleased existing<br />

investors but also raised the interest of new<br />

ones such as the aws Gruenderfonds. Ralf<br />

Kunzmann, CEO of aws Gruenderfonds,<br />

comments: "We‘re happy to support Erich<br />

Tauber and his team in the further development<br />

of the promising prophylactic vaccines<br />

for emerging tropical infectious diseases<br />

and to be part of the strong investor<br />

syndicate. We are looking forward to take<br />

the next steps together with Themis."<br />

Dr Gerd Zettlmeissl, chairman of the supervisory<br />

board of Themis, comments on<br />

the future company plans: "We are grateful<br />

for the trust of our existing and new investors<br />

and I am pleased to welcome Ralf Kunzmann<br />

of the aws Gruenderfonds as a new<br />

member of our supervisory board.<br />

“The new capital will primarily be dedicated<br />

to finalise the phase 2 clinical trial of<br />

our Chikungunya vaccine and to prepare<br />

for respective phase 3 trials.” Furthermore,<br />

Themis will use the additional investment<br />

to continue the exploitation of the knowhow<br />

it acquired with the Chikungunya vaccine's<br />

development for further prophylactic<br />

vaccines. These include a vaccine against<br />

the Zika virus whose advance into the clinical<br />

trial phase by Themis was recently supported<br />

by the United Kingdom's innovation<br />

agency, Innovate UK, with 1 Mio. GBP.<br />

About Themis (November <strong>2016</strong>):<br />

Themis Bioscience GmbH develops prophylactic<br />

vaccines from the preclinical to<br />

the early clinical phase, focusing on emerging<br />

tropical infectious diseases, with initial<br />

vaccine candidates currently being developed<br />

against Chikungunya and Zika. The<br />

company's highly innovative and fully patent-protected<br />

measles virus vaccine vector<br />

technology platform, licensed from the<br />

internationally respected Institut Pasteur in<br />

Paris, forms the basis for all current vaccine<br />

candidates of the Vienna-based company.<br />

www.themisbio.com<br />

About the vaccine technology<br />

(November <strong>2016</strong>):<br />

The scientific basis for Themis' measles<br />

vector Themaxyn® platform has been developed<br />

at the Institut Pasteur in Paris and<br />

is licensed to Themis. It relies on the use<br />

of the standard measles vaccine as a vaccination<br />

vector. Genes coding for selected<br />

antigens from the chikungunya virus have<br />

been inserted into the genome of this<br />

well-established vaccine. The measles-chikungunya<br />

vaccine delivers the chikungunya<br />

antigens directly to macrophages and<br />

dendritic cells – the most potent and effective<br />

antigen-presenting cells, thereby triggering<br />

a specific immune response to chikungunya<br />

virus. This results in a powerful,<br />

antigen-focused immune response, which<br />

is most likely to confer long-term immunity<br />

as does the measles vaccine.<br />

About aws Gruenderfonds<br />

(November <strong>2016</strong>):<br />

aws Gruenderfonds is Austrian's leading<br />

venture capital fund with around EUR<br />

70 M EUR under management. The parent<br />

company is the Austrian Wirtschaftsservice<br />

Gesellschaft mbH (aws). The fund invests<br />

in Austrian startups with high growth potential<br />

in their early growth or expansion<br />

stage. aws Gründerfonds is a long term<br />

partner who takes hands-on approach and<br />

actively assembles a syndicate of international<br />

co-investors out of their international<br />

network. Currently the fund has invested<br />

in 20 startups, further investments in the<br />

life science segment include e.g. Miracor<br />

Medical Systems and Panoptes.<br />

VOL. 25 NO. 6 | DECEMBER <strong>2016</strong><br />

Nikon's ALL NEW Inverted<br />

Microscope Platform for<br />

Advanced Imaging<br />

Eclipse Ti2<br />

Ground-breaking FOV 25mm<br />

Nikon Perfect Focus System<br />

Intelligent assist guide<br />

18mm<br />

25mm<br />

Routine Systems North Island | Melanie Kennerley | Ph: (021) 480 044<br />

Routine Systems South Island | Tony Bradshaw | Ph: (09) 292 7290<br />

Advanced Microscopy Systems | Dr Rob Woolley | Ph: (021) 288 8636<br />

sales@coherent.com.au | www.coherent.com.au<br />

[ 5 ]


NEW ZEALAND LABORATORY NEWS | NEW ZEALAND BIOSCIENCE<br />

VOL. 25 NO. 6 | DECEMBER <strong>2016</strong><br />

Ginolis launches revolutionary lateral flow<br />

device assembly solution<br />

Ginolis Ltd, a leading provider of high<br />

precision liquid handling and intelligent<br />

desktop automation for MedTech<br />

industries, recently announced the launch of<br />

the revolutionary LFDA-3, the intelligent lateral<br />

flow device assembly solution.<br />

The world leading lateral flow device assembly<br />

solution provides manufacturers flexible<br />

production capacity within a desktop<br />

footprint.<br />

The LFDA-3 is built on Ginolis´modular<br />

Xanthia robotic platform.<br />

The modular design provides speed, accuracy<br />

and precision, as well as flexibility for<br />

the future. The solution is easily adaptable and<br />

PRODUCT NEWS<br />

Thermo Scientific Smart-vue<br />

Wireless Sample Monitoring Solution<br />

Thermo Scientific Smart-Vue solutions<br />

protect precious samples by monitoring<br />

key laboratory parameters including<br />

temperature, CO2 concentration, humidity<br />

and differential pressure.<br />

The Smart-Vue solution can be installed on<br />

most laboratory equipment, including ultralow<br />

temperature freezers, laboratory refrigerators,<br />

CO2 incubators and in clean rooms.<br />

This intuitive, wireless monitoring solution is<br />

can assemble different rapid tests with minimal<br />

product specific adjustments. Machine<br />

vision guidance throughout the entire system<br />

ensures a consistent high quality assembled<br />

device.<br />

“The LFDA revolutionizes the rapid test<br />

manufacturing market. One system can assemble<br />

multiple rapid test devices with little<br />

or no changeover time,” states Jorma Venäläinen,<br />

VP of sales and marketing at Ginolis Ltd.<br />

“Vision guided component placement,<br />

strip cutting and assembly throughout the<br />

process ensures fast production times with<br />

high quality results.”<br />

The revolutionary new desktop solution<br />

designed for controlled laboratory environments<br />

such as pharmaceutical research and<br />

production, IVF clinics, tissue banking and<br />

diagnostic laboratories, where sample protection<br />

and monitoring is a priority. To facilitate<br />

regulatory compliance with various protocols,<br />

Smart-Vue provides full audit-trail traceability.<br />

By continuously monitoring ambient conditions,<br />

the Smart-Vue wireless monitoring<br />

solution protects sensitive laboratory samples<br />

comes equipped with machine vision guidance,<br />

real time quality control, bulk feeders,<br />

proprietary Ginger software and a host of additional<br />

features.<br />

The LFDA-3 is available with single card,<br />

card magazine or reel infeed.<br />

The desktop solution has an extremely<br />

quick changeover time and production capabilities<br />

up to 30 units/minute.<br />

The LFDA-3 allows you to realise all the<br />

benefits of automating your manufacturing<br />

process in a footprint that is less than three<br />

square meters.<br />

The company is showcasing the LFDA-3 for<br />

the first time at Medica trade fair in Düsseldorf,<br />

Germany on November 14 – 17. Visit Ginolis<br />

Ltd at Hall 1 stand B15.<br />

with immediate remote alarm notifications.<br />

It creates a permanent record of all readings,<br />

alarms and acknowledgements with the responder’s<br />

personal identification. It is accessible<br />

via the Internet anytime, anywhere.<br />

Smart-Vue can be easily installed, set up<br />

and maintained. The multilingual, user-installed<br />

software automatically identifies and<br />

pre-configures module protocols for easeof-use.<br />

The highly efficient and cost-effective<br />

Smart-Vue solution is fully scalable and flexible,<br />

and it is compatible with multiple brands<br />

and types of laboratory equipment.<br />

www.thermofisher.co.nz/<br />

wirelessmonitoring<br />

NEW from Molecular Devices: Rapid, accurate DNA, RNA,<br />

and protein quantitation in a one-touch, full-spectrum<br />

micro-volume absorbance reader<br />

The SpectraMax® QuickDrop Micro-Volume<br />

Spectrophotometer addresses the<br />

needs of life science researchers who<br />

[ 6 ]<br />

quantify very small amounts of DNA, RNA, oligos,<br />

and proteins. The QuickDrop Spectrophotometer<br />

allows you to set up your laboratory<br />

with a minimal investment of time, cost, and<br />

effort.<br />

Quantitate micro-volume samples with ease<br />

The QuickDrop Spectrophotometer provides<br />

you with the flexibility to work with your<br />

micro-volume samples in the platform that<br />

best suits your research. The built-in sample<br />

port allows you to work with volumes as small<br />

as 0.5 μL, preserving your precious samples,<br />

while the cuvette port lets you expand your<br />

work to include larger volume samples.<br />

The QuickDrop Spectrophotometer is a<br />

stand-alone unit with a small footprint and<br />

does not require a direct connection to a dedicated<br />

computer. The large, high-resolution<br />

touchscreen interface offers you the ability<br />

to take advantage of pre-configured analysis<br />

methods, set up your customized experiment<br />

with ease, or export your data to a USB flash<br />

drive for additional analysis.<br />

Increased sensitivity without sacrificing<br />

speed<br />

With a four second read time and no moving<br />

parts to skew the sample, or to potentially<br />

break, the QuickDrop Spectrophotometer<br />

maintains an accurate pathlength, providing<br />

you with results that are both fast and reliable,<br />

regardless of viscosity.<br />

For more information please contact Bio-<br />

Strategy<br />

T: 0800 34 24 66<br />

E: info@bio-strategy.com<br />

www.bio-strategy.com


NEW ZEALAND LABORATORY NEWS | NEW ZEALAND BIOSCIENCE<br />

VOL. 25 NO. 6 | DECEMBER <strong>2016</strong><br />

[ 7 ]


NEW ZEALAND LABORATORY NEWS | NEW ZEALAND BIOSCIENCE<br />

VOL. 25 NO. 6 | DECEMBER <strong>2016</strong><br />

First random laser made of paper-based ceramics<br />

A new biotemplating process<br />

makes it possible to create lasers<br />

out of cellulose paper.<br />

Working with physicists from the University<br />

of Rome, a team led by Professor<br />

Cordt Zollfrank from the Technical<br />

University of Munich (TUM) built the first<br />

controllable random laser based on cellulose<br />

paper in Straubing.<br />

The team thereby showed how naturally<br />

occurring structures can be adapted for technical<br />

applications.<br />

Hence, materials no longer need to be artificially<br />

outfitted with disordered structures,<br />

utilizing naturally occurring ones instead.<br />

Material synthesis that is inspired by biology<br />

is an area of research at TUM’s Chair of<br />

Biogenic Polymers at the Straubing Center<br />

of Science. It utilises models from nature and<br />

biogenic materials to develop new materials<br />

and technologies. The latest issue of the publication<br />

“Advanced Optical Materials” features<br />

a basic study by a joint team from Straubing<br />

and Rome who succeeded in “using a biological<br />

structure as a template for a technical<br />

random laser,” according to scientist Dr Daniel<br />

Van Opdenbosch.<br />

Two components are necessary for a laser:<br />

[ 8 ]<br />

PRODUCT NEWS<br />

Nikon’s all new Inverted Microscope<br />

Platform for advanced imaging – see<br />

more than before<br />

The Eclipse Ti2 delivers an unparalleled<br />

25mm field of view (FOV) that<br />

revolutionises the way you see. With<br />

this incredible FOV, the Ti2 maximises<br />

the sensor area of large-format CMOS<br />

cameras without making compromises, and<br />

significantly improves data throughput. The<br />

Ti2’s exceptionally stable, drift-free platform<br />

is designed to meet the demands of superresolution<br />

imaging while its unique hardware<br />

First of all, a medium which amplifies light.<br />

And secondly, a structure which retains the<br />

light in the medium.<br />

A classic laser uses mirrors to order and<br />

shine light in a single direction in a targeted,<br />

uniform fashion.<br />

This also takes place uniformly in the microscopic<br />

structure of a random laser, but in<br />

different directions.<br />

Although the development of the random<br />

laser is still in its infancy, in the future it could<br />

result in lower-cost production.<br />

This is because random lasers have the advantage<br />

that they are direction-independent<br />

and function with multiple colors, just to<br />

name a few benefits.<br />

Disordered structure deflects light in all<br />

directions<br />

“The prerequisite for a random laser is a<br />

defined degree of structural chaos on the<br />

interior,” Dr Van Opdenbosch explained. The<br />

light in a random laser is therefore scattered<br />

at all manner of angles along random paths,<br />

which are determined by an irregular structure<br />

in the interior of the medium. The team<br />

led by Professor Zollfrank from the Chair of<br />

Biogenic Polymers in Straubing used conventional<br />

laboratory filter paper as a structural<br />

template.<br />

“Due to its long fibers and the resulting<br />

triggering capabilities enhance even the<br />

most challenging, high-speed imaging<br />

applications. Furthermore, the Ti2’s unique,<br />

intelligent functions guide users through<br />

imaging workflows by gathering data from<br />

internal sensors, eliminating the possibility<br />

of user errors. In addition, the status of each<br />

sensor is automatically recorded during<br />

acquisition, providing quality control for<br />

imaging experiments and enhancing data<br />

reproducibility. In combination with Nikon’s<br />

powerful acquisition and analysis software,<br />

NIS-Elements, the Ti2 is a total innovation in<br />

imaging.<br />

Compact, High-Definition, High-Speed<br />

and High-Sensitivity C-mount Camera<br />

Nikon’s DS-Fi3 is a new high-definition<br />

colour microscope camera equipped with a<br />

5.9 megapixel CMOS image sensor. Its highspeed<br />

data readout, superior colour reproduction<br />

and high quantum efficiency are<br />

optimal for imaging in various observations,<br />

such as brightfield, DIC, phase contrast and<br />

fluorescence observation.<br />

The DS-Fi3 is equipped with a 5.9 mega-<br />

stable structure, we deemed it to be suitable<br />

for this purpose,” said Dr Van Opdenbosch.<br />

In the laboratory, the paper was impregnated<br />

with tetraethyl orthotitanate, an organometallic<br />

compound.<br />

When it is dried and the cellulose burned<br />

off at 500 degrees Celsius, it leaves behind the<br />

ceramic titanium dioxide as residue — the<br />

same substance generally used in sunblock to<br />

provide protection from the sun.<br />

“This effect in sunblock is based on titanium<br />

dioxide’s strong light scattering effect,”<br />

said Dr Van Opdenbosch, “which we also utilised<br />

for our random laser.<br />

“Our laser is ‘random’ because the light<br />

which is scattered in different directions due<br />

to the biogenic structure of the laboratory filter<br />

paper can also be scattered in the opposite<br />

direction,” he added, explaining the principle.<br />

Random laser not that random after all<br />

However, the light waves can still be controlled<br />

despite their random nature, as the<br />

team led by Claudio Conti of the Institute for<br />

Complex Systems in Rome discovered, with<br />

whom Daniel Van Opdenbosch and Cordt<br />

Zollfrank collaborated.<br />

With the help of a spectrometer, they were<br />

able to differentiate the various laser wavelengths<br />

generated in the material and localise<br />

them separately from one another.<br />

pixel CMOS image sensor, which enables<br />

the capture of high-definition images of<br />

up to 2880 x 2048 pixels. With a new CMOS<br />

image sensor and high-speed data transfer<br />

via USB3.0, the DS-Fi3 enables fast focusing<br />

even in high-resolution imaging, and efficient<br />

image acquisition when using a wide<br />

range of illumination techniques.<br />

For further information please contact<br />

Tony Bradshaw<br />

Coherent Scientific Pty Ltd<br />

tony.bradshaw@coherent.com.au<br />

www.coherent.com.au

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