Curriculum vitae Achim Weber Assistant Professor of Molecular ...

Achim Weber
Curriculum vitae
Assistant Professor of Molecular Pathology (tenure track)
Department of Pathology, Institute of Surgical Pathology
Schmelzbergstr. 12
CH-8091 Zürich
phone: +41 44 255 2781
achim.weber@usz.ch
born July, 28 th 1968 in Gillenfeld / Germany
University education
1988-1994 Medical School, Johannes Gutenberg-University Mainz, Germany (M.D.)
Licensure and Certification
1994
1995
1996
2006
2006
2007
2008
Professional record
Doctor of Medicine, Johannes Gutenberg-University Mainz, Germany
United States Medical Licensing Examination (USMLE Step 1 und Step 2)
German federal licence to practice medicine (Approbation)
Board certification as Pathologist (Germany)
Board certification as Molecular Pathologist (Germany)
Board certification as Molecular Pathologist (FMH - Switzerland)
Habilitation (University Lecturer), University of Zurich, Switzerland
1995-1996 Internship, Medical Department (Hematology, Oncology, Rheumatology),
Ruprecht-Karls-University Heidelberg
1996-1998 Resident, Institute of Pathology, Heinrich-Heine-University Düsseldorf
1998-2001 Visiting Research Fellow, Laboratory of Pathology, Gene Regulation Section,
National Cancer Institute, NIH, Bethesda, MD, USA
2001-2003 Resident, Institute of Pathology, Molecular Pathology Section, Eberhard-Karls-
University Tübingen
2003-2006 Resident / staff pathologist, Institute of Pathology, Johannes Gutenberg-University
Mainz
2006-2010 Staff pathologist, Department of Pathology, Institute of Surgical Pathology,
University Hospital Zürich
2010 - Assistant Professor of Molecular Pathology (tenure track), Department of
Pathology, Institute of Surgical Pathology, University Hospital Zürich
Major Responsibilities
2005-2006
2007-
Head, Laboratory of diagnostic molecular pathology, University Mainz
Head, Laboratory of molecular endocrine pathology, University Hospital Zürich

Awards and prizes
1990-1994
1998-1999
1999-2001
2007
2008
2010
Research grants
Students excellence scholarship (Cusanuswerk)
Research Fellowship (German Research Foundation - DFG)
Fogarty Research Fellowship (Fogarty Centre, Bethesda, MD, USA)
George Tiniakos Award (best contribution in gastrointestinal, liver and pancreas
pathology; 22th Meeting of the European Society of Pathology, Istanbul)
Poster prize, Swiss Society of Pathology (SGPath)
Poster prize, International Academy of Pathology (IAP), Spring Meeting
Deutsche Forschungsgemeinschaft (DFG)
Julius Müller Stiftung zur Unterstützung der Krebsforschung
Kurt und Senta Hermann Stiftung
Oncosuisse Research Funding
Swiss National Science Fond (SNF)
UBS Wealth Management
Zurich Center for Integrative Physiology (ZHIP)
Reviewer activity
Journals
BMC Infectious Diseases
Clinical Cancer Research
Digestion
Gut
Journal of Clinical Pathology
Journal of Hepatology
Pathology Research and Practice
Funding Organizations
Swiss Cancer League
Germany Society for Cancer Research (Deutsche Krebsgesellschaft)
Professional memberships
Germany Society of Pathology (DGP) since 1996
Germany Society for Cancer Research (Deutsche Krebsgesellschaft) since 1996
International Academy of Pathology (IAP) since 2003
Germany Society for Cell Biology (DGZ) since 2004
Swiss Society of Pathology (SGPath) since 2007
Swiss Society of Molecular Pathology since 2008

Selected publications
Liver and GI pathology
Weber A*, Boger R*, Vick B, Urbanik T, Haybaeck J, Zoller S, Teufel A, Krammer PH,
Opferman JT, Galle PR, Schuchmann M, Heikenwalder M, Schulze-Bergkamen H (2010)
Hepatocyte-specific deletion of the anti-apoptotic protein Mcl-1 triggers proliferation and
hepatocarcinogenesis in mice. Hepatology 51(4):1226-36 IF (2009): 10.840
Bettermann K, Vucur M, Koppe C, Heymann F, Haybaeck J, Weber A, Weiskirchen R, Liedtke
C, Gassler N, Müller M, Akira S, Tacke F, Heikenwalder M, Trautwein C, Luedde T (2010)
TAK1 suppresses a NEMO-dependent, but NF-�B independent pathway to liver cancer. Cancer
Cell 17:481-496 IF (2009): 25.288
Malz M*, Weber A*, Singer S, Riehmer V, Bissinger M, Riener MO, Longerich T, Soll C,
Vogel A, Angel P, Schirmacher P, Breuhahn K (2009) Overexpression of far upstream element
binding proteins: A mechanism regulating proliferation and migration in liver cancer cells.
Hepatology 50(4):1130-9 IF (2009): 10.840
Paradis V, Weber A (2010) Histology and pathology of normal and diseased liver (steatosis,
fibrosis, cirrhosis). Malignant Liver Tumors, 3rd edition, Chapter 4, Editor PA Clavien, John
Wiley & Sons
Haybaeck J * , Zeller N * , Wolf MJ, Weber A, Wagner U, Kurrer MO, Bremer J, Iezzi G, Graf R,
Clavien PA, Thimme R, Blum H, Nedospasov SA, Zatloukal K, Mohammad R, Ciesek S,
Pietschmann T, Marche PN, Karin M, Kopf M, Browning JL, Aguzzi A, Heikenwalder M (2009)
A lymphotoxin-driven pathway to hepatocellular carcinoma. Cancer Cell 16(4):295-308. IF
(2009): 25.288
Scharl M, Paul G, Weber A, Jung BC, Docherty MJ, Hausmann M, Rogler G, Barrett KE,
McCole DF (2009) Protection of epithelial barrier function by the Crohn's disease associated
gene, protein tyrosine phosphatase N2. Gastroenterology 137(6):2030-2040 IF (2009):
12.899
de Rougemont O, Breitenstein S, Leskosek B, Weber A, Graf R, Clavien PA, Dutkowski P
(2009) One hour hypothermic oxygenated perfusion (HOPE) protects nonviable liver allografts
donated after cardiac death. Ann Surg 250(5):674-83 IF (2009): 7.900
Vick B, Weber A, Urbanik T, Krammer PH, Opfermann JT, Schuchmann M, Galle PR, Schulze-
Bergkamen H (2009) Knock-out of Myeloid cell leukemia-1 induces profound liver damage and
increases apoptosis susceptibility of murine hepatocytes. Hepatology 49(2):627-36. IF
(2009): 10.840
Gene regulation
Weber A, Chung JH, Springer E, Heitzmann D, Warth R (2010) The TFIIH subunit p89 (XPB)
localizes to the centrosome during mitosis. Cellular Oncology 32:121-130 IF (2009): 4.169

Weber A, Gutierrez MI, Levens D (2006) The CT-element of the c-myc gene does not predispose
to chromosomal breakpoints in Burkitt's lymphoma. Cell Oncol 28(1-2):31-35 IF (2006): 2.979
Liu J, Kouzine F, Nie Z, Chung HJ, Elisha-Feil Z, Weber A, Zhao K, Levens D (2006) The
FUSE/FBP/FIR/TFIIH system is a molecular machine programming a pulse of c-myc expression.
EMBO J 25(10):2119-30 IF (2006): 10.086
Weber A*, Liu J*, Collins I, Levens D (2005) TFIIH operates through an expanded proximal
promoter to fine-tune c-myc expression. Mol Cell Biol 25(1):147-61 IF (2005): 7.093
Liu J, Akoulitchev S, Weber A, Ge H, Chuikov S, Libutti D, Wang XW, Conaway JW, Harris
CC, Conaway RC, Reinberg D, Levens D (2001) Defective interplay of activators and repressors
with TFIH in xeroderma pigmentosum. Cell 104(3), 353-363 IF (2001): 29.219
Collins I, Weber A, Levens D (2001) Transcriptional consequences of topoisomerase inhibition.
Mol Cell Biol 21(24):8437-51 IF (2001): 9.836
He L, Weber A, Levens D (2000) Nuclear targeting determinants of the far upstream element
binding protein, a c-myc transcription factor. Nuc Acid Res 28(22):4558-65 IF (2000): 5.396
Clinical Pathology
Ikenberg K, Springer E, Bräuninger W, Kerl K, Mihic D, Schmid S, Schmitt A, Yeginsoy S,
Bode B, Weber A (2010) Oropharyngeal lesions and cervical lymphadenopathy: syphilis is a
differential diagnosis that is still relevant. J Clin Pathol 63(8):731-6. IF (2009): 2.333
Weber A, Zimmermann DR, Moch H (2010) KRAS-Mutationsstatus und kolorektales Karzinom.
Kapitel: KRAS-Diagnostik. UNIMED SCIENCE, Uni-MED Verlag AG.
Anlauf M, Bauersfeld J, Raffel A, Krausch M, Koch CA, Henopp T, Alkatout I, Schmitt A,
Weber A, Kruse ML, Braunstein S, Kaserer K, Dralle H, Moch H, Heitz PU, Komminoth P,
Knoefel WT, Perren A, Klöppel G (2009) Insulinomatosis: A Multicentric Insulinoma Disease
that Frequently Causes Early Recurrent Hyperinsulinemic Hypoglycemia. Am J Surg Pathol
33(3):339-46 IF (2009): 4.062
Berhof W, Springer E, Bräuninger W, Kirkpatrick CJ, Weber A (2008) PCR testing for
Treponema pallidum in paraffin-embedded skin biopsy specimens: test design and impact on the
diagnosis of syphilis. J Clin Pathol 61(3):390-95 IF (2008): 2.342
Heinrich S, Pestalozzi BC, Schäfer M, Weber A, Bauerfeind P, Knuth A, Clavien PA (2008)
Prospective phase II trial of neoadjuvant chemotherapy with gemcitabine and cisplatin for
resectable adenocarcinoma of the pancreatic head. J Clin Oncol 26(15):2526-31 IF (2008):
17.157
Heinrich S, Schäfer M, Weber A, Hany TF, Bhure U, Pestalozzi BC, Clavien PA (2008)
Neoadjuvant Chemotherapy Generates a Significant Tumor Response in Resectable Pancreatic
Cancer Without Increasing Morbidity: Results of a Prospective Phase II Trial. Ann Surg
248(6):1014-22 IF (2008): 8.460

Ebinger M, Sotlar K, Weber A, Bock CT, Bültmann BD, Kandolf R (2006) Simplified detection
of microsatellite instability in colorectal cancer without the need for corresponding germline
DNA analysis. J Clin Pathol 59(10):1114-15 IF (2006) 2.245
Kreft A, Weber A, Springer E, Hess G, Kirkpatrick CJ (2007) Bone marrow findings in
multicentric Castleman disease in HIV-negative patients. Am J Surg Pathol 31(3):398-402
IF (2007): 4.181
Hansen T, Kunkel M, Kirkpatrick CJ, Weber A (2006) Actinomyces in infected
osteoradionecrosis--underestimated? Hum Path 37(1):61-67 IF (2006): 2.810
Kröber SM, Kaiserling E, Horny HP, Weber A (2004) Primary diagnosis of Whipple's disease in
bone marrow. Hum Path 35(4):522-25 IF (2004): 3.396