PeloNews Feb/March2019

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From Bedside to Bench: Translating
Clinical Tumour Treatments into 3D Culture
'Translational research' is mainly seen as the effort to develop basic research
into clinical routine, this webinar shows how 3D culture systems
may serve as a comprehensive tool to reproduce patient treatment protocols
in your laboratory.
From a lab perspective, the clinical situation looks amazingly simple:
Both patients and doctors do not bother much about biological endpoints
as apoptosis or DNA damage of cancer cells, but focus on general ones:
Does the tumour shrink? And finally: Is the tumour cured?
Applying such 'simple' endpoints on 3D tumour cell cultures can make a
lot of sense:
Volume response as a readout summarises all anti-tumour effects
into one
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Watch now here
In long-term cultures, each single micro-tumour may be assigned to
be either 'cured' or 'resistant'
The concept of clonal evolution requires time and large 'cohorts" of
micro-tumours. Size-based screening is an efficient method to detect
specific mutations and other rare events. In this webinar, you will
learn:
How to design and apply complex treatment schedules to microtumours,
as chemoradiation, fractionated radiotherapy and hyperthermia
treatment •
How to handle cancer cell types that normally do not grow as spheroids
How optical scanning and paraffin sections are easily used to assess
treatment response
How to detect and isolate micro-tumours that did not respond to treatment
Watch now this great vivid lecture by Dr. Thomsen.