March 2019 digital v1
Create successful ePaper yourself
Turn your PDF publications into a flip-book with our unique Google optimized e-Paper software.
slug<br />
progressive work on the same happening to<br />
take it forward?<br />
Not on the same, but yes, there are<br />
many good works happening around. The<br />
researchers are thinking in different ways and<br />
are exploring new mechanisms to target the<br />
ribosome, among others and also to find out<br />
different factors that cause natural mutation<br />
within the bacteria that gives them resistance.<br />
There aren’t anything in the same way, which<br />
I know; though we don›t think ours was the<br />
best. We are also exploring further.<br />
Multi-drug resistant tuberculosis is a<br />
very serious medical challenge in India and<br />
also in many other Asian countries. How<br />
do we explain the resistance mechanism in<br />
I think there is<br />
scope for exploring<br />
new antibiotics<br />
for treating<br />
drug-resistant<br />
tuberculosis,<br />
targeting<br />
ribosomes.<br />
tuberculosis, where drugs are not targeting<br />
ribosomes?<br />
There are also some tuberculosis drugs<br />
targeting ribosomes of late. But, most of<br />
the existing drugs target cell walls, cell<br />
cycles and checkpoint controls and other<br />
pathways. Although we have not focused<br />
on tuberculosis as such so far, I think there<br />
is scope for exploring new antibiotics for<br />
treating drug-resistant tuberculosis, targeting<br />
ribosomes.<br />
How do bugs continue to develop<br />
resistance to more and more antibiotics?<br />
It is part of the natural survival<br />
[mechanism] of organisms. As I said before,<br />
there are natural mutations that take place<br />
38 / FUTURE MEDICINE / <strong>March</strong> <strong>2019</strong>