Warfarin interaction2
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No. Food Possible MOA Potential Effect<br />
Towards INR<br />
1. Cranberry Juice Inhibitor of CYP enzyme<br />
2. Garlic Intrinsic antiplatelet activity<br />
3. Chitosan Impairment of absorption of<br />
vitamin A, D, E, K<br />
4. Kale (Cooked) 531 mcg of Vit K in ½<br />
cup<br />
5. Spinach (Cooked) 444 mcg of Vit K in<br />
½ cup<br />
6. Mustards green (Raw) 279 mcg of Vit<br />
K in 1 cup<br />
7. Parsley (Raw) 246 mcg of Vit K in ¼<br />
cup<br />
8. Brussels sprouts (Cooked) 219 mcg of<br />
Vit K in 1 cup<br />
9. Spinach (Raw) 145 mcg of Vit K in 1<br />
cup<br />
10. Broccoli (Raw) 89 mcg of Vit K in 1<br />
cup<br />
11. Cabbage (Cooked) 82 mcg of Vit K in<br />
½ cup<br />
12. Kailan (Cooked) 74.62 mcg of Vit K in<br />
1 cup<br />
Supplementation of vitamin K<br />
Supplementation of vitamin K<br />
Supplementation of vitamin K<br />
Supplementation of vitamin K<br />
Supplementation of vitamin K<br />
Supplementation of vitamin K<br />
Supplementation of vitamin K<br />
Supplementation of vitamin K<br />
Supplementation of vitamin K<br />
13. Alcohol Chronic alcohol intake<br />
Can induce warfarin metabolism<br />
by cytochrome P450 and increase<br />
warfarin clearance<br />
Acute alcohol intake<br />
<strong>Warfarin</strong> metabolism may be<br />
decreased, leading to<br />
supratherapeutic INR<br />
14. Soy Speculative mechanisms of soy<br />
milk-induced INR decline such as<br />
changes in warfarin absorption or<br />
metabolism resulting from<br />
alterations in P-glycoprotein<br />
efflux system or organic aniontransporting<br />
polypeptides
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