Warfarin interaction2

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No. Food Possible MOA Potential Effect Towards INR 1. Cranberry Juice Inhibitor of CYP enzyme 2. Garlic Intrinsic antiplatelet activity 3. Chitosan Impairment of absorption of vitamin A, D, E, K 4. Kale (Cooked) 531 mcg of Vit K in ½ cup 5. Spinach (Cooked) 444 mcg of Vit K in ½ cup 6. Mustards green (Raw) 279 mcg of Vit K in 1 cup 7. Parsley (Raw) 246 mcg of Vit K in ¼ cup 8. Brussels sprouts (Cooked) 219 mcg of Vit K in 1 cup 9. Spinach (Raw) 145 mcg of Vit K in 1 cup 10. Broccoli (Raw) 89 mcg of Vit K in 1 cup 11. Cabbage (Cooked) 82 mcg of Vit K in ½ cup 12. Kailan (Cooked) 74.62 mcg of Vit K in 1 cup Supplementation of vitamin K Supplementation of vitamin K Supplementation of vitamin K Supplementation of vitamin K Supplementation of vitamin K Supplementation of vitamin K Supplementation of vitamin K Supplementation of vitamin K Supplementation of vitamin K 13. Alcohol Chronic alcohol intake Can induce warfarin metabolism by cytochrome P450 and increase warfarin clearance Acute alcohol intake <strong>Warfarin</strong> metabolism may be decreased, leading to supratherapeutic INR 14. Soy Speculative mechanisms of soy milk-induced INR decline such as changes in warfarin absorption or metabolism resulting from alterations in P-glycoprotein efflux system or organic aniontransporting polypeptides
No. Food Possible MOA Potential Effect Towards INR 15. Mango Retinol (vitamin A) inhibits CYPC219 (which warfarin R isomer) 16. Curcumin Inhibition P-gp, further improving adsorption of warfarin 17. Pineapple Inhibition of CYPC29 (due to bromelain) 18. Mangosteen Inhibition of CYP2C9 19. Pomegranate Inhibit metabolism involving the cytochrome P450 system 20. Ginger Reduced platelet aggregation Unquantifiable
Page 8: DECREASE Taken from: PHARMACEUTICAL
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Warfarin interaction2

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